Nerve fibres: a possible role in keloid pathogenesis

Hochman, Bernardo; Nahas, Fábio Xerfan; Sobral, Christiane Steponavicius; Arias, Viviana; Locali, Rafael Fagionato; Juliano, Yára; Ferreira, Lydia Masako

doi:10.1111/j.1365-2133.2007.08401.x

Cited by 35 publications

(38 citation statements)

References 10 publications

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“…a lower relief in the central compared with the peripheral area) and with minimum dimensions 3 cm at the longitudinal axe and 2 cm at the transversal axe. Keloid location was delimited in the thoracic region, between a transverse plane at the level of the acromion and a transverse plane at the level of xiphoid process 3 . Were excluded keloids previously treated or patients with chronic dermatopathies, metabolic, collagen or degenerative / auto-immune diseases, malignant neoplasms, or patients submitted to systemic or topic treatment with corticosteroids.…”

Section: Collection Of Keloid Samplesmentioning

confidence: 99%

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In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts

et al. 2011

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Purpose:To quantify keloid fibroblasts after irradiation with 470nm blue LED, in vitro. Methods: Fibroblasts from keloid and adjacent skin have been obtained from 6 patients. Cells have been cultivated and maintained in DMEM culture medium. In Petri dishes, they were irradiated with energy doses of 6J, 12J and 18J. After 24 h, counting was done by the average of the triplicates for each sample. Results: There were no significant differences in the number of irradiated keloid fibroblasts at the studied doses (p=0.261). In adjacent skin fibroblasts, differences were observed (p=0.025) concerning the doses of 18 J and 6 J (p=0.03). Conclusions: There was a reduction in the number of adjacent skin fibroblasts irradiated with 470nm blue LED at the energy dose of 18 J compared to the ones irradiated at the energy dose of 6 J. There were no changes in keloid fibroblasts counting at any of the doses applied, 24 h after irradiation. Key words: Fibroblasts. Keloid. Phototherapy. Lasers. Skin. Laser Therapy, Low-Level. RESUMOObjetivo: Quantificar fibroblastos de quelóide após irradiação com LED azul de 470nm, in vitro. Métodos: Foram obtidos fibroblastos de quelóide e pele adjacente, de seis pacientes. As células foram cultivadas e mantidas em meio de cultura DMEM. Em placas de Petri, receberam irradiação com doses de energia de 6J, 12J e 18J. Após 24 horas a contagem foi feita pela média da triplicata para cada amostra. Resultados: Não houve diferença na quantidade de fibroblastos de quelóide irradiados nas doses estudadas (p=0,261). Observou-se diferença nos fibroblastos de pele adjacente (p=0,025), com relação às doses de 18 J e 6 J (p=0,03). Conclusões: Houve redução dos fibroblastos de pele adjacente irradiados com LED azul de 470 nm na dose de energia de 18 J em relação à dose de 6 J. Não houve alteração na quantidade de fibroblastos de quelóide nas doses aplicadas após 24 horas da irradiação.

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Section: Collection Of Keloid Samplesmentioning

confidence: 99%

“…Keloid is a wound repair disorder resulting from excessive collagen deposition, which occurs in susceptible individuals, and its pathophysiology has not yet been fully elucidated [1][2][3] . The literature presents many options of treatment, alone or in combination, nevertheless they are not specific.…”

Section: Introductionmentioning

confidence: 99%

In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts

et al. 2011

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“…As a direct consequence, the neurogenic inflammation promotes the release of cytokines and growth factors, inducing extracellular matrix synthesis by fibroblasts in the healing phase. The neurogenic inflammation has a direct modulatory effect on the subsequent phases of the healing process, especially on the proliferative phase [45][46][47].…”

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confidence: 99%

The action of CGRP and SP on cultured skin fibroblasts

Hochman

Tucci-Viegas²,

Monteiro

et al. 2014

Open Life Sciences

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“…Hypertrophic scars show a higher density of nerve fibers when compared to normotrophic scars 14,18 . Similarly, it has also been shown that keloids have the highest density of nerve fibers in the dermis of the skin, and are found in deeper areas 17 . In addition, skin pigmentation influences cutaneous thermoregulation.…”

Section: Discussionmentioning

confidence: 89%

“…This system acts mainly in the skin, controlling inflammation, immunity, functional regulation of cutaneous structures, thermoregulation, homeostasis modulation, and wound healing 11,16 . Thus, the aggressive exposure of melanocytes to sun radiation, which affects the cutaneous nervous system, might cause pathological skin disorders, also impairing wound healing 15,17 . This observation strengthens the possible correlation between keloid scars and cutaneous nervous system, since nerve fi bers and melanocytes have the same neuroectodermal origin 1 .…”

Section: Discussionmentioning

confidence: 99%

Distribuição de queloide e cicatriz hipertrófica segundo fototipos de pele de Fitzpatrick

Hochman¹,

Farkas²,

Isoldi³

et al. 2012

Rev. Bras. Cir. Plást.

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Background: Keloid and hypertrophic scars have a common physiopathogenic origin and are defined as fibroproliferative scars. Fibroproliferative scars are frequent in indivi duals with darker skin. However, mixing of "races" renders it difficult to group patients with different skin tones according to morphological and static classifications (white for Caucasians; brown for individuals of Spanish descent (Hispanic/Latino); yellow for indi viduals of East Asian descent; and black for individuals of African descent) according to their response to sun exposure. It is known that when individuals whose ethnic origin is in colder countries move to tropical countries, they show a higher incidence of these types of scars, which mainly affect parts of the body that are more exposed to the sun. A correlation between fibroproliferative scars and Fitzpatrick phototype, a dynamic classification based on the skin's response to sun exposure, would contribute to an understanding of the patho physiology of these scars. The aim of this study is to investigate the distribution of fibro proliferative scars according to Fitzpatrick phototypes. Methods: We classified patients' fibroproliferative scars according to the Muir classification as Long-Term Evolution (keloid scars), Short-Term Evolution (hypertrophic scars), and Intermediate Group (mixed scars), while their skin types were grouped according to the Fitzpatrick classification. Results: Fitzpatrick phototype III and mixed scars were predominant among the patients analyzed (p = 0.001). A correlation (p = 0.025) was observed between fibroproliferative scars and Fitzpatrick phototypes; the higher the phototype, the higher the tendency to develop keloid and mixed scar tissue. Conclusions: Fitzpatrick skin phototypes proved to be an efficient method to study keloid and hypertrophic scars.Keywords: Keloid. Cicatrix, hypertrophic. Skin pigmentation. Melanocytes. Ultraviolet rays. RESUMO Introdução:Queloide e cicatriz hipertrófica são cicatrizes patológicas com natureza fi siopatogênica comum, denominadas, em conjunto, cicatrizes fibroproliferativas. São mais frequentes em indivíduos de pele mais escura. Contudo, a atual miscigenação dificulta o enquadramento dos pacientes com variadas tonalidades de pele em classificações morfo lógicas e estáticas (branco ou caucasoide, mulato, pardo, hispânico ou latino, amarelo ou oriental ou mongoloide e negro ou negroide), e diferentes quanto à exposição solar. Sabe -se que pessoas oriundas de países de clima temperado ou frio quando residem em países

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Nerve fibres: a possible role in keloid pathogenesis

Cited by 35 publications

References 10 publications

In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts

In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts

The action of CGRP and SP on cultured skin fibroblasts

Distribuição de queloide e cicatriz hipertrófica segundo fototipos de pele de Fitzpatrick

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