Nerve conduction study on patients with severe liver syndrome and its change after transplantation

Lee, Jung H.; Jung, Woo Jin; Choi, Kyoung Hyo; Chun, Min Ho; Ha, Sang Bae; Lee, Seung K

doi:10.1034/j.1399-0012.2002.02063.x

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Finally, Lee et al performed nerve conduction studies in 25 patients with end‐stage liver disease before and 6 months after OLT 9. The causes of the liver failure and the results of neurological examination were not given.…”

Section: Discussionmentioning

confidence: 99%

Resolution of alcoholic neuropathy following liver transplantation

2004

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Between 10 and 20% of adult liver transplants are performed for end-stage alcoholic liver disease. Severe extrahepatic end-organ damage from alcoholism (cardiomyopathy, pancreatitis, central nervous system injury, and neuropathy) is widely regarded as an absolute contraindication to liver transplantation, despite a lack of data on the effect of transplantation on these complications. We describe such a patient who presented with decompensated alcoholic liver disease and moderately severe peripheral neuropathy. Both his liver failure and neuropathy progressed despite 9 months abstinence and intensive nutritional support. By 12 months post-transplant, however, this patient had regained almost normal muscle strength, with associated recovery in sensory and motor conduction velocities. Direct alcohol toxicity, nutritional and vitamin deficiencies, and liver failure were all likely etiologic factors in this patient's neuropathy. In conclusion, this case suggests that peripheral neuropathy in a patient with alcoholic cirrhosis may resolve following liver transplantation and should not constitute a contraindication to transplantation, even when it is disabling.

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Section: Discussionmentioning

confidence: 99%