Nerve conduction studies in amyotrophic lateral sclerosis

Interpretation of electrodiagnostic findings in sporadic progressive muscular atrophy

“…In our patients, the NCS values did not fulfill criteria for demyelination, except for one DML, and they are therefore compatible with a diagnosis of MND according to the revised El Escorial criteria [30] and in keeping with those reported in ALS [9,11,20]. Decreased CMAPs occurred both in combination with decreased and normal MCV.…”

“…Nerve conduction studies are required to exclude treatable disorders of the peripheral nerve, especially multifocal motor neuropathy [10,14]. Although nerve conduction studies are generally normal in ALS, mild to modest abnormalities in these studies have been described [1,9,11,20,26,27,32].…”

Usefulness of phrenic latency and forced vital capacity in patients with ALS with latent respiratory dysfunction

“…Usually, prolongation of latency is associated with the decrease of CMAP amplitude in NCS of patients with ALS (de Carvalho and Swash, 2000). However, in the previous study which performed ulnar NCS, a few hands with either fasciculation only, without other abnormal findings such as weakness, atrophy or exaggeration of finger jerks, showed normal CMAP amplitude despite of prolongation of latency (Mills and Nithi, 1998).…”

Assessment of Motor Units in Neuromuscular Disease

“…The Neurophysiology Index, developed by Swash and de Cavalho [62,63], relies on the formula of the CMAP size/ latency × F-wave persistence, and was conceived as a practical measure utilizing typical measures obtained with standard nerve conduction studies. It has largely been studied in the ulnar nerve.…”