Usefulness of phrenic latency and forced vital capacity in patients with ALS with latent respiratory dysfunction

Kwon, Soonwook; Min, Ju-Hong; Cho, Hyejin; Joo, Byung‐Euk; Cho, Eun Bin; Seok, Jin Myoung; Kim, Minji; Kim, Byoung Joon

doi:10.1016/j.clinph.2014.10.006

Cited by 10 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The phrenic nerve assessment proved to be a reliable means of predicting respiratory failure, as previously demonstrated in ALS patients (33)(34)(35), particularly when spirometry is not possible owing to limitations due to the illness (36). The chest X-ray and subsequent restrictive failure confirmed the diaphragmatic weakness.…”

Section: Discussionsupporting

confidence: 55%

64. Acute flaccid paralysis by Enterovirus D68 infection: First Italian description on adult patient and role of electrophysiology

Ceccanti¹,

Rubino²,

Romanzi³

et al. 2017

Clinical Neurophysiology

View full text Add to dashboard Cite

A Peruvian woman was admitted to the Emergency Department, due to an acute flaccid paralysis (AFP) of the upper limbs that progressively involved also lower limbs and respiratory muscles. She previously suffered from non-Hodgkin's lymphoma and had to undergo hematopoietic stem cell transplantation. A magnetic resonance imaging showed a T2 hyperintensity in the anterior and central region of the cervical segment with an elective involvement of gray matter. This finding, combined with other clinical, laboratory, and electrophysiological data, led to a diagnosis of AFP. Enterovirus D68 was isolated in the patient's cerebrospinal fluid, plasma, and throat swab. To our knowledge, this is the first Italian case of AFP by Enterovirus D68 infection in an adult. The diagnostic assessment and management of AFP by Enterovirus D68 are discussed.

show abstract

Section: Discussionsupporting

confidence: 55%

64. Acute flaccid paralysis by Enterovirus D68 infection: First Italian description on adult patient and role of electrophysiology

Ceccanti¹,

Rubino²,

Romanzi³

et al. 2017

Clinical Neurophysiology

View full text Add to dashboard Cite

show abstract

“…Nerve conduction studies of the PN were not correlated to ALS region of onset, signifying that the loss of motor units was comparable whether the region of onset was bulbar or spinal [20]. The ALSFRS-R score was likewise not correlated to PN conduction studies [7]. These studies along with our study may suggest that the PN CSA and the PN conduction studies are not reliable markers to show changes in relation to the ALSFRS-R score or ALS region of onset.…”

Section: Discussionmentioning

confidence: 99%

“…Diaphragm thickness was observed to be reduced in ALS and it is correlated with measures of respiratory function [2][3][4][5]. Phrenic nerve (PN) motor conduction studies have also been used to evaluate the respiratory function and have been observed to detect latent respiratory dysfunction as well as predict survival in ALS [7,8].…”

Section: Introductionmentioning

confidence: 99%

Utility of phrenic nerve ultrasound in amyotrophic lateral sclerosis

et al. 2020

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting the upper and lower motor neurons causing progressive weakness. It eventually involves the diaphragm which leads to respiratory paralysis and subsequently death. Phrenic nerve (PN) conduction studies and diaphragm ultrasound has been studied and correlated with pulmonary function tests in ALS patients. However, PN ultrasonography has not been employed in ALS. This study aims to sonographically evaluate the morphologic appearance of the PN of ALS patients. Thirty-eight ALS patients and 28 normal controls referred to the neurophysiology laboratory of two institutions were retrospectively included in the study. Baseline demographic and clinical variables such as disease duration, ALS Functional Rating Scale-Revised score, and ALS region of onset were collected. Ultrasound was used to evaluate the PN cross-sectional area (CSA) of ALS and control subjects. The mean PN CSA of ALS patients were 1.08 ± 0.39 mm on the right and 1.02 ± 0.34 mm on the left. The PN CSA of ALS patients were significantly decreased compared to controls (p value < 0.00001). The PN CSA of ALS patients was not correlated to any of the demographic and clinical parameters tested. This study demonstrates that ALS patients have a smaller PN size compared to controls using ultrasonography.

show abstract

“…The phrenic nerve assessment proved to be a reliable means of predicting respiratory failure, as previously demonstrated in ALS patients ( 33 – 35 ), particularly when spirometry is not possible owing to limitations due to the illness ( 36 ). The chest X-ray and subsequent restrictive failure confirmed the diaphragmatic weakness.…”

Section: Discussionmentioning

confidence: 60%

Acute Flaccid Paralysis by Enterovirus D68 Infection: First Italian Description in Adult Patient and Role of Electrophysiology

et al. 2017

View full text Add to dashboard Cite

A Peruvian woman was admitted to the Emergency Department, due to an acute flaccid paralysis (AFP) of the upper limbs that progressively involved also lower limbs and respiratory muscles. She previously suffered from non-Hodgkin’s lymphoma and had to undergo hematopoietic stem cell transplantation. A magnetic resonance imaging showed a T2 hyperintensity in the anterior and central region of the cervical segment with an elective involvement of gray matter. This finding, combined with other clinical, laboratory, and electrophysiological data, led to a diagnosis of AFP. Enterovirus D68 was isolated in the patient’s cerebrospinal fluid, plasma, and throat swab. To our knowledge, this is the first Italian case of AFP by Enterovirus D68 infection in an adult. The diagnostic assessment and management of AFP by Enterovirus D68 are discussed.

show abstract

Usefulness of phrenic latency and forced vital capacity in patients with ALS with latent respiratory dysfunction

Cited by 10 publications

References 29 publications

64. Acute flaccid paralysis by Enterovirus D68 infection: First Italian description on adult patient and role of electrophysiology

64. Acute flaccid paralysis by Enterovirus D68 infection: First Italian description on adult patient and role of electrophysiology

Utility of phrenic nerve ultrasound in amyotrophic lateral sclerosis

Acute Flaccid Paralysis by Enterovirus D68 Infection: First Italian Description in Adult Patient and Role of Electrophysiology

Contact Info

Product

Resources

About