Nerve Allografts and Conduits in Peripheral Nerve Repair

Lin, Michael; Manzano, Givenchy; Gupta, Ranjan

doi:10.1016/j.hcl.2013.04.003

Cited by 101 publications

(76 citation statements)

References 119 publications

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“…Nerve tubulation approach to the repair of peripheral nerve gaps can be traced back to the nineteenth century. Gluck (Gluck, 1881) performed the first experiment of nerve tabulation, with a tube of decalcified bone to aid the approximation of transected nerve ends, in animals [78,84,85]. Later, Dahlin and Lundborg [86] developed the first synthetic tube, made of silicone.…”

Section: Nerve Conduitsmentioning

confidence: 99%

“…The use of non-neuronal tissue as conduits was first reported by Büngner (Büngner, 1891), when he successfully used a segment of human brachial artery to regenerate a gap in sciatic nerve [84]. The use of arterial grafts has been demonstrated [94,95] but is associated with high morbidity.…”

Section: Biological Conduitsmentioning

confidence: 99%

“…Also, lack of donor vessels makes this a less popular approach in nerve repair. However, it has been described that neurovascular injuries in the hand have benefited from the use of homolateral arteries in the repair [40,84] nerve or muscle tissue. This supplementation has the added advantage of supplying neurotrophic factors and ECM (muscle fibres) and has been described to facilitate nerve regeneration across longer gaps by promoting SCs migration, cell proliferation and guidance of the axonal growth cone [84].…”

Section: Biological Conduitsmentioning

confidence: 99%

“…Another type of biological conduit is tendon autograft. Although with only theoretically and historic interest, ECM macrostructure and the presence of hyaluronic acid have been described to enhance regenerating in the nerve cone [84]. AxoGuard™ is the only FDA-approved device composed by small intestine submucosa (SIS) extracellular matrix ( Table 2).…”

Section: Biological Conduitsmentioning

confidence: 99%

“…As nerve conduits collagen allows the establishment of topographical cues that guide axons to regrow [105,106] and has shown excellent cell adhesive properties that encourage cell attachment and proliferation [106,107]. The degradation time of the collagen conduits is relatively prolonged and takes up to 48 months which can cause nerve compression and fibrosis [84]. The first commercially available collagen Table 2).…”

Section: Collagenmentioning

confidence: 99%

See 4 more Smart Citations

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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Section: Nerve Conduitsmentioning

confidence: 99%

Section: Biological Conduitsmentioning

confidence: 99%

Section: Biological Conduitsmentioning

confidence: 99%

Section: Biological Conduitsmentioning

confidence: 99%

Section: Collagenmentioning

confidence: 99%

See 3 more Smart Citations

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

View full text Add to dashboard Cite

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3D Manufacture of Gold Nanocomposite Channels Facilitates Neural Differentiation and Regeneration

Qian

Song

Zheng

et al. 2018

Adv Funct Materials

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Conductive nerve guidance channels are promising alternative therapies in peripheral nerve tissue engineering because they have excellent biocompatibility, biodegradation, and electrical conductivity. Gold, a kind of conductive material, is investigated widely concerning its potential roles in promoting peripheral nerve repair. In the present study, a polydopamine-coated gold/ polycaprolactone nanoscaffold is fabricated via a multilayer molding method and its proliferative, adhesive, and neural differentiation potential for bone marrow mesenchymal stem cells (BMSCs) and Schwann cells (SCs) in vitro is evaluated. Functional, electrophysiological evaluation, and morphological assessment all exhibit satisfactory recovery of sciatic nerves with increased thickness and number of myelinated fibers in vivo. In addition, increased microvessels are confirmed in gold nanocomposite channels, indicating their potential benefits in angiogenesis. Functional regeneration is further enhanced by neurotrophic growth factors released from BMSC and SC loading. The gold nanocomposite channel will have great potential in peripheral nerve restoration.

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Repairing Peripheral Nerves: Is there a Role for Carbon Nanotubes?

Oprych

Whitby

Mikhalovsky

et al. 2016

Adv Healthcare Materials

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Peripheral nerve injury continues to be a major global health problem that can result in debilitating neurological deficits and neuropathic pain. Current state‐of‐the‐art treatment involves reforming the damaged nerve pathway using a nerve autograft. Engineered nerve repair conduits can provide an alternative to the nerve autograft avoiding the inevitable tissue damage caused at the graft donor site. Commercially available nerve repair conduits are currently only considered suitable for repairing small nerve lesions; the design and performance of engineered conduits requires significant improvements to enable their use for repairing larger nerve defects. Carbon nanotubes (CNTs) are an emerging novel material for biomedical applications currently being developed for a range of therapeutic technologies including scaffolds for engineering and interfacing with neurological tissues. CNTs possess a unique set of physicochemical properties that could be useful within nerve repair conduits. This progress report aims to evaluate and consolidate the current literature pertinent to CNTs as a biomaterial for supporting peripheral nerve regeneration. The report is presented in the context of the state‐of‐the‐art in nerve repair conduit design; outlining how CNTs may enhance the performance of next generation peripheral nerve repair conduits.

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Nerve Allografts and Conduits in Peripheral Nerve Repair

Cited by 101 publications

References 119 publications

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

3D Manufacture of Gold Nanocomposite Channels Facilitates Neural Differentiation and Regeneration

Repairing Peripheral Nerves: Is there a Role for Carbon Nanotubes?

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