Nerolidol derivatives from Asteriscus sericeus

Jakupovic, Jasmin; Lehmann, L.; Bohlmann, Ferdinand; Hogdson, A.Arroyo

doi:10.1016/s0031-9422(00)83606-7

Cited by 22 publications

(9 citation statements)

References 4 publications

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“…The chemical shifts of the C-atoms of 1 and 3 ( Table 3) suggested the structure of 6oxocyclonerolidol and 6a-hydroxycyclonerolidol (Fig. The chemical shifts of H-and C-atoms of these compounds were previously reported by Jacupovic et al [16] in a solvent extract from Astericus sericeus. The chemical shifts of H-and C-atoms of these compounds were previously reported by Jacupovic et al [16] in a solvent extract from Astericus sericeus.…”

supporting

confidence: 61%

Chemical Diversity of Essential Oils from Asteriscus graveolens (Forssk.) Less.: Identification of cis‐8‐Acetoxychrysanthenyl Acetate as a New Natural Component

Cristofari

Znini²,

Majidi³

et al. 2012

Chemistry & Biodiversity

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Asteriscus graveolens is an endemic medicinal plant mainly distributed in south-western Algeria and south-eastern Morocco. The essential oils of leaves, stems, and flowers of A. graveolens had been studied by GC, GC/MS, and (13) C-NMR. The spectral data of two nerolidol derivatives, 6-oxo- and 6-hydroxycyclonerolidol, were reassigned by 1D- and 2D-NMR spectroscopy. These compounds can be considered as chemical markers of this genus. The structure of a monoterpenic diester with a chrysanthenane skeleton, i.e., cis-8-acetoxychrysanthenyl acetate, was determined for the first time on the basis of GC/MS, and 1D- and 2D-NMR. The stem and leaf oils were characterized by high content of oxygenated sesquiterpenes with 6-oxo- and 6-hydroxycyclonerolidol as major components, and the flower essential oils were dominated by the new monoterpenic compound cis-8-acetoxychrysanthenyl acetate.

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supporting

confidence: 61%

Chemical Diversity of Essential Oils from Asteriscus graveolens (Forssk.) Less.: Identification of cis‐8‐Acetoxychrysanthenyl Acetate as a New Natural Component

Cristofari

Znini²,

Majidi³

et al. 2012

Chemistry & Biodiversity

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“…The asteriscunolide isomers are sesquiterpene lactones containing a humulene skeleton. These compounds were previously isolated from Asteriscus graveolens , [5,10,20] Asteriscus aquaticus , [21,22] Asteriscus sericeus , [23] and Asteriscus vogelii [24] . Sesquiterpene lactones, and specifically humulanolides are known to have therapeutic activities [5] and are generally found in the Asteraceae family [5,20] .…”

Section: Resultsmentioning

confidence: 99%

Chemo‐Geographic Variations in Wild Population of Asteriscus graveolens in Israel Based on Volatile Composition Analyses

Ben-Gera

Mashraki

Sharma

et al. 2020

Chemistry & Biodiversity

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Asteriscus graveolens is an aromatic desert shrub which holds medicinal potential. This species belongs to the Asteraceae family and is endemic to the Mediterranean region. In the present study, wild plants were sampled from eleven locations throughout southern Israel and the volatile profiles from leaves and flowers were analyzed using GC/MS. Three methods for volatile sampling were tested for a representative population: solvent extraction (methyl tert-butyl ether), hydrodistillation of the essential oil and headspace solid-phase microextraction. In all methods, the majority of volatiles were characterized as oxygenated mono-and sesquiterpenes. Only solvent extraction was able to detect asteriscunolides that were previously reported as anticancer molecules. Hence, that method was chosen for further analyses. The leaves were dominated by three asteriscunolide isomers, cischrysanthenyl acetate and intermedeol. The flowers were dominated by bisabolone, 6-hydroxybisabol-2-en-1one, cis-chrysanthenyl acetate, epi-α-cadinol, and germacrene-D. k-Means clustering analysis of these data divided the population into four clusters that significantly differ in their volatile composition as was further demonstrated by MANOVA analysis. Geographically, A. graveolens populations growing in Israel were found to be chemically diverse with unique varieties in the Dead Sea basin and the Arava region. This work demonstrates that chemo-geographic variation of volatile composition exists within A. graveolens population growing in Israel, so future research evaluating the medicinal potential of that plant should take this into consideration.

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“…It is used to treat various ailments such as fever, gastrointestinal diseases, headache, bronchitis and also as an anti-inflammatory 5 . The aerial part (flowers and leaves) is rich in EO and is especially characterized by a high content of oxygenated terpene compounds such as Chrysanthenyl acetate and Oxocyclonerolidol, which are described in other Asteriscus species, and can be considered chemo-taxonomically as markers of the genus 6,7 . Following our literature search, the literature on the study of the biological activity of this plant is limited to 9 articles, 3 of which deal with its antibacterial activity [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity and central and peripheral analgesic activity of flowers and leaves essential oils of Asteriscus graveolens from South-West Algeria

Benaissa

Megherbi

Said

et al. 2020

J. Drug Delivery Ther.

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The objective of this study is the evaluation of the central and peripheral analgesic activity of the leaves and flowers Essential Oils (EOs) of Asteriscus graveolens as well as their acute toxicity. The pharmacological tests were performed using an animal model. Acute toxicity was determined by Lorke's method. Central analgesic activity was evaluated by the hot plate test, and peripheral analgesic activity was conducted by the writhing test. The results showed that the EOs of A. graveolens from both organs are weakly toxic. For the central analgesic activity, the results revealed that leaf EO have a remarkable antinociceptive effect compared to flowers EO with a maximum latency time of the animals on the hot plate on the order of 22.5 seconds. Finally, the peripheral analgesic activity revealed a maximum inhibition of abdominal writhing of 99% for flowers EO and 96% for leaves EO. Keywords: Asteriscus graveolens, analgesic activity, toxicity.

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Nerolidol derivatives from Asteriscus sericeus

Cited by 22 publications

References 4 publications

Chemical Diversity of Essential Oils from Asteriscus graveolens (Forssk.) Less.: Identification of cis‐8‐Acetoxychrysanthenyl Acetate as a New Natural Component

Chemical Diversity of Essential Oils from Asteriscus graveolens (Forssk.) Less.: Identification of cis‐8‐Acetoxychrysanthenyl Acetate as a New Natural Component

Chemo‐Geographic Variations in Wild Population of Asteriscus graveolens in Israel Based on Volatile Composition Analyses

Acute toxicity and central and peripheral analgesic activity of flowers and leaves essential oils of Asteriscus graveolens from South-West Algeria

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