Nephrotoxic effect of tetradifon in rats: A biochemical and histomorphometric study

Badraoui, Riadh; Nasr, Hmed Ben; Louati, Rim; Ellouze, Fériel; Rebaï, Tarek

doi:10.1016/j.etp.2010.12.008

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…Although the radical scavenging activities of the complex were lower than the standards, (2‐HAMP) 2 [CoBr 4 ] exhibits good antioxidant activity once compared with BHT and Vit C. These results confirmed previous studies regarding antioxidant potentials of chemical compounds [26,36,37] . Several studies highlighted the importance of antioxidants against several pathologies, genotoxicity and cancer [25,26,37,38] …”

Section: Resultssupporting

confidence: 85%

“…These cells were kindly provided by Pr D. Chappard and Dr S. Blouin (Medicine Department of Angers University). The malignant cells have a high osteolytic potential, induced osteosclerotic and osteolytic tumor lesions [4,25,26] . The cells were grown in suspension in DMEM medium, which was supplemented with 5 % fetal calf serum, 1 % of non‐essential amino acids complexed with penicillin (100 UI/mL), streptomycin sulphate (100 g/mL) and sodium pyruvate (1 mM).…”

Section: Methodsmentioning

confidence: 99%

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Physico‐Chemical Properties, Pharmacokinetics, Molecular Docking and In‐Vitro Pharmacological Study of a Cobalt (II) Complex Based on 2‐Aminopyridine

et al. 2022

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The organic‐inorganic hybrid compound (2‐HAP)2[CoBr4], (2‐HAP=2‐protonated aminopyridinium cation) was characterized by various physicochemical techniques. Hirshfeld surfaces and 2D fingerprint plots reveal the intermolecular interactions accountable for the generation of the crystal packing. The differential scanning calorimetric (DSC) disclosed three phase transitions at T1=61.9 °C, T2=107.6 °C and T3=172 °C. The electronic parameters such as frontier molecular orbitals, HOMO‐LUMO energy and electrochemical band gaps (E’g) were computed. The redox properties of the complex were examined by cyclic voltammetry. The thermodynamic properties of the compound were computed for the range temperature of 100–1000 K. The antioxidant activities were examined using DPPH, ABTS, β‐carotene and FRAP assays. The anticancer effects were evaluated using malignant Mat−Ly−Lu and Walker 256/B cell lines. The antiviral effects of the organic part of the hybrid compound were tested using molecular docking; interestingly, the binding predicted energy was −4.0 vs −5.3 kcal/mol, for chloroquine as a reference. The drug‐likeness, pharmacokinetics, molecular binding and chemo‐preventive assays show that (2‐HAMP)2[CoBr4] has promising biological potentials.

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Section: Resultssupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Physico‐Chemical Properties, Pharmacokinetics, Molecular Docking and In‐Vitro Pharmacological Study of a Cobalt (II) Complex Based on 2‐Aminopyridine

et al. 2022

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“…After MX treatment, rats' serum creatinine and urea levels increased considerably, indicating purine and pyrimidine breakdown as well as decreased renal function. A rise in creatinine and urea in the serum of rats subjected to hazardous chemicals, such as pesticides, have been reported in several studies [55][56][57][58]. In line with the present results, Yassin, et al [59] recorded a general increase in serum urea, creatinine, and bilirubin of chlorpyrifos intoxicated rabbits while a diminished total protein level was also observed .…”

Section: Discussionsupporting

confidence: 91%

Protective effect of acetylcysteine against thiamethoxam-induced hepatic and renal toxicity in rats

2022

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The biochemical, oxidative DNA damage, and the histological alterations associated with thiamethoxam (MX) exposure, a second-generation neonicotinoid broadly used in Egyptian agriculture, were assessed. Also, the role of N-acetylcysteine (NAC), (150 mg/kg/ day) on the adverse effect of MX was investigated. Rats were orally preserved with a sub-lethal dose (1/50 LD 50 ) of MX at 31.26 mg/kg/day, five doses/week for 28 days. The MX exposure resulted in a significant decrease in rats' body weight, protein concentration of both serum and urine, sera catalase (CAT), and glutathione peroxidase (GPx) activities compared to control. In addition increase in sera creatinine, urea, bilirubin, alkaline phosphatase (ALP), superoxide dismutase (SOD), and malondialdehyde (MDA) levels were observed. While the assessment of DNA damage revealed significant altitude in 8-hydroxy-2'-deoxyguanosine (8-OH-2DG) levels in both serum and urine samples. The present findings were supported by microscopic observation of liver and kidney tissues. Evidently, thiamethoxam can damage liver and kidney functions impaired the DNA, and cause histoarchitecture lesions in rats at the tested sublethal dose. In addition, NAC supplementation significantly attenuated of MX adverse effect which reflects its protective influence against MXinduced hepatic-nephrotoxicity.

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“…Recent findings have shown that oxidative stress can cause cell damage [ 9 , 35 , 36 , 37 ] and delay wound healing [ 38 ]. The formation of free radicals and a low capacity to scavenge ROS are causative of skin lesions.…”

Section: Resultsmentioning

confidence: 99%

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

et al. 2021

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In our study, Allium subhirsutum L. (AS) was investigated to assess its phenolic profile and bioactive molecules including flavonoids and organosulfur compounds. The antioxidant potential of AS and wound healing activity were addressed using skin wound healing and oxidative stress and inflammation marker estimation in rat models. Phytochemical and antiradical activities of AS extract (ASE) and oil (ASO) were studied. The rats were randomly assigned to four groups: group I served as a control and was treated with simple ointment base, group II was treated with ASE ointment, group III was treated with ASO ointment and group IV (reference group; Ref) was treated with a reference drug “Cytolcentella® cream”. Phytochemical screening showed that total phenols (215 ± 3.5 mg GAE/g) and flavonoids (172.4 ± 3.1 mg QE/g) were higher in the ASO than the ASE group. The results of the antioxidant properties showed that ASO exhibited the highest DPPH free radical scavenging potential (IC50 = 0.136 ± 0.07 mg/mL), FRAP test (IC50 = 0.013 ± 0.006 mg/mL), ABTS test (IC50 = 0.52 ± 0.03 mg/mL) and total antioxidant capacity (IC50 = 0.34 ± 0.06 mg/mL). In the wound healing study, topical application of ASO performed the fastest wound-repairing process estimated by a chromatic study, percentage wound closure, fibrinogen level and oxidative damage status, as compared to ASE, the Cytolcentella reference drug and the untreated rats. The use of AS extract and oil were also associated with the attenuation of oxidative stress damage in the wound-healing treated rats. Overall, the results provided that AS, particularly ASO, has a potential medicinal value to act as effective skin wound healing agent.

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Nephrotoxic effect of tetradifon in rats: A biochemical and histomorphometric study

Cited by 10 publications

References 34 publications

Physico‐Chemical Properties, Pharmacokinetics, Molecular Docking and In‐Vitro Pharmacological Study of a Cobalt (II) Complex Based on 2‐Aminopyridine

Physico‐Chemical Properties, Pharmacokinetics, Molecular Docking and In‐Vitro Pharmacological Study of a Cobalt (II) Complex Based on 2‐Aminopyridine

Protective effect of acetylcysteine against thiamethoxam-induced hepatic and renal toxicity in rats

The Role of Allium subhirsutum L. in the Attenuation of Dermal Wounds by Modulating Oxidative Stress and Inflammation in Wistar Albino Rats

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