Nephrotic Syndrome is Associated with Increased Risk of Ischemic Stroke

Huang, Jen‐Chieh; Lin, Ching-Heng; Chang, Yun-Chi; Lee, Cheng-Ting; Wu, Ming‐Ju

doi:10.1016/j.jstrokecerebrovasdis.2019.104322

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…Thus, psychological stress may trigger proteinuria in children with steroid-sensitive NS [ 24 ] and mood changes could be associated with corticosteroid therapy for NS [ 23 ]. In adults with NS, a study conducted in Taiwan suggested a correlation between NS and ischaemic stroke [ 25 ].…”

Section: Association Of Increased Albuminuria With MCI and Dementiamentioning

confidence: 99%

Albuminuria as a risk factor for mild cognitive impairment and dementia—what is the evidence?

Bikbov

Soler

Pešić

et al. 2021

Nephrology Dialysis Transplantation

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Section: Association Of Increased Albuminuria With MCI and Dementiamentioning

confidence: 99%

Albuminuria as a risk factor for mild cognitive impairment and dementia—what is the evidence?

Bikbov

Soler

Pešić

et al. 2021

Nephrology Dialysis Transplantation

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“…However, other studies found RVT as the most common, with varying rates reported in several other studies [9]. The risk of ischemic strokes increases in patients with nephrotic syndrome with age >45 years, male gender, and heart failure [10]. Moreover, proteinuria to serum albumin ratio is a predictor for VTE, while hypertension, diabetes, smoking, estimated glomerular filtration rate, and prior ATE are identified predictors for ATE [8].…”

Section: Discussionmentioning

confidence: 95%

A Case of a Thrombotic Storm (Arterial and Venous) in Nephrotic Syndrome

Wireko¹,

Nanduri²,

Ngonge³

et al. 2022

Cureus

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Nephrotic syndrome is a condition characterized by proteinuria, hypoalbuminemia, edema, hyperlipidemia, and a hypercoagulable state. Nephrotic syndrome may lead to several complications, including, but not limited to, increased risk of infection, respiratory distress, and thromboembolism. There are several etiologies of nephrotic syndrome with various predisposing factors ranging from idiopathic, autoimmune diseases, infections (human immunodeficiency virus, hepatitis C virus, hepatitis B virus), drugs, and heavy metal poisoning.Here, we report the case of a 37-year-old male who presented with worsening exertional dyspnea and bilateral lower extremity swelling. He was found to have simultaneous multiple acute thromboses in both the venous and arterial systems in the setting of worsening renal function. Further investigation revealed that the patient had membranous nephropathy. Initiation of anticoagulation and immunosuppression made a significant difference in his survival.Vascular thromboembolic (VTE) complications may be the initial presentation that prompts patients with nephrotic syndrome to seek medical care. As such, clinicians must have a high index of suspicion in patients presenting with concurrent VTE and nephrotic-range proteinuria. In addition, given that treatment modalities for the various etiologies of nephrotic syndrome differ considerably, it is also essential to distinguish the type of nephrotic syndrome in a patient, which dictates the treatment algorithm.

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“…14,15 Previous studies of NS patients have reported increased risk of VTE, 16,17 cardiovascular heart disease, 17,18 and ischemic stroke. 17,19 The risk of VTE in NS patients has been reported to be 3% during initial hospitalization, 20 and 2-10% during up to 10 years of follow-up. [21][22][23] Interestingly, higher risk of ATE in NS patients have been reported including a 3-year risk of cardiovascular events of 8% 24 and 10-year risk of ATE of 15%.…”

Section: Introductionmentioning

confidence: 99%