Risk of Arterial Thromboembolism, Venous Thromboembolism, and Bleeding in Patients with Nephrotic Syndrome: A Population-Based Cohort Study

Vestergaard, Søren Viborg; Birn, Henrik; Darvalics, Bianka; Nitsch, Dorothea; Sørensen, Henrik Toft; Christiansen, Christian Fynbo

doi:10.1016/j.amjmed.2021.11.018

Cited by 9 publications

(8 citation statements)

References 48 publications

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“…Thromboembolism could usually be divided into venous thrombosis and arterial thrombosis. Although the symptoms of arterial thrombosis are more obvious than those of patients with venous thrombosis, the condition of arterial thrombosis is generally more serious, and the delayed treatment also affects the prognosis and quality of life of patients ( 13 ). Most NS patients with pulmonary vascular thrombosis do not present the classic triad of pulmonary embolism, and their clinical manifestations could range from asymptom to tachypnea and tachycardia, and even sudden death ( 14 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: A case of recurrent thrombosis in pediatric antiphospholipid syndrome associated with pediatric onset systemic lupus

Liu

Liu²,

Zhang³

et al. 2023

Front. Pediatr.

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Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-system involvement as the main manifestation, and has complex and diverse clinical features. Studies on large samples have revealed that SLE patients have a significantly increased risk of thrombotic events, which are also one of the important causes of morbidity and mortality in SLE patients. Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by recurrent arterial and venous thrombosis, pregnancy-related complications, and the persistence of antiphospholipid antibodies at a 12-week interval. There are few reports about SLE coexisting with APS in children. This paper reported a school-age patient who started the disease with gross hematuria after bumping into the waist. The initial diagnosis of renal contusion was then confirmed by color Doppler ultrasound as renal vein and inferior vena cava embolism. She suddenly developed severe chest pain and dyspnea 3 days after hospitalization. And imaging supported pulmonary embolism with massive proteinuria, hypoalbuminemia, and hypercholesterolemia. The initial diagnosis was nephrotic syndrome (NS) with arteriovenous embolization, and popliteal vein embolism occurred again 5 years later, and she was thus diagnosed with SLE coexisting with APS. Afterwards, we discussed the possible mechanism and therapeutic strategies of SLE&APS that started with nephrotic syndrome, in order to achieve early identification and treatment of the disease and improve the prognosis of children.

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Section: Discussionmentioning

confidence: 99%

Case Report: A case of recurrent thrombosis in pediatric antiphospholipid syndrome associated with pediatric onset systemic lupus

Liu

Liu²,

Zhang³

et al. 2023

Front. Pediatr.

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“…S. Vestergaard и соавт. в крупном исследовании у 3967 пациентов с впервые развившимся НС в течение первого года выявили повышение риска артериальных и венозных тромбоэмболий в 3,11 и 7,11 раза, соответственно, по сравнению с таковым в общей популяции [40]. Высокий риск не только венозных, но и артериальных тромбоэмболических осложнений у пациентов с НС, особенно в течение первых 6 мес после его развития, отмечен и в некоторых других исследованиях [41].…”

Section: тромбоэмболические осложненияunclassified

Nephrotic syndrome: treatment and prevention of complications

Moiseev,

Bobkova,

Chebotareva

et al. 2024

CPT

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Nephrotic syndrom (NS) that frequently occurs in patients with various glomerular disease can cause serious and even life-threatening complications including diuretic-resistant oedema, hypovolemic shock, venous and arterial thromboembolism, and infections. Moreover, high proteinuria and dyslipidemia in patients with NS may contribute to progression of chronic kidney disease. The authors review treatment of NS and prevention of its complications.

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“…Primary nephrotic syndrome (PNS) is a renal disease with unclear mechanisms and complex pathological types, which is normally accompanied by various lesions in the capillary walls of the glomeruli and characterized by edema, heavy proteinuria, and hypoalbuminemia. 1 Severe complications such as thromboembolism and acute renal failure appear commonly along with PNS progress, which are the main factors for high mortality and disability rates. 1 Timely and precise monitoring and detection of PNS are beneficial to the formulation and implementation of treatment protocols, positively improving the prognosis and preventing complications.…”

Section: ■ Introductionmentioning

confidence: 99%

“…1 Severe complications such as thromboembolism and acute renal failure appear commonly along with PNS progress, which are the main factors for high mortality and disability rates. 1 Timely and precise monitoring and detection of PNS are beneficial to the formulation and implementation of treatment protocols, positively improving the prognosis and preventing complications. Currently, renal puncture plays a gold standard role in PNS diagnosis and pathological typing, whereas it is an invasive operation with limited safety and low acceptance among patients, resulting in severe limitations in clinical application.…”

Section: ■ Introductionmentioning

confidence: 99%

In Vitro Diagnostic Examination and Prognosis Surveillance by Hierarchical Heterojunction-Assisted Metabolic Analysis

Shi

Zhou

et al. 2022

Anal. Chem.

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High-throughput metabolic analysis based on laser desorption/ionization mass spectrometry exhibits broad prospects in the field of large-scale precise medicine, for which the assisted ionization ability of the matrix becomes a determining step. In this work, the gold-decorated hierarchical metal oxide heterojunctions (dubbed Au/HMOHs) are proposed as a matrix for extracting urine metabolic fingerprints (UMFs) of primary nephrotic syndrome (PNS). The hierarchical heterojunctions are simply derived from metal–organic framework (MOF)-on-MOF hybrids, and the native built-in electric field from heterojunctions plus the extra Au decoration provides remarkable ionization efficiency, attaining high-quality UMFs. These UMFs are employed to realize precise diagnosis, subtype classification, and effective prognosis evaluation of PNS by appropriate machine learning, all with 100% accurate ratios. Moreover, a high-confidence marker panel for PNS diagnosis is constructed. Interestingly, all panel metabolite markers present obviously uniform downregulation in PNS compared to healthy controls, shedding light on mechanism exploration and pathway analysis. This work drives the application of metabolomics toward precision medicine.

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Risk of Arterial Thromboembolism, Venous Thromboembolism, and Bleeding in Patients with Nephrotic Syndrome: A Population-Based Cohort Study

Cited by 9 publications

References 48 publications

Case Report: A case of recurrent thrombosis in pediatric antiphospholipid syndrome associated with pediatric onset systemic lupus

Case Report: A case of recurrent thrombosis in pediatric antiphospholipid syndrome associated with pediatric onset systemic lupus

Nephrotic syndrome: treatment and prevention of complications

In Vitro Diagnostic Examination and Prognosis Surveillance by Hierarchical Heterojunction-Assisted Metabolic Analysis

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