Nephrotic syndrome as the presenting feature of malignant thymoma

Schillinger, F; Milcent, Thierry; Wolf, Christian; Gulino, R.; Montagnac, R

doi:10.1093/ndt/12.12.2732

Cited by 13 publications

(9 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6] Cases of nephrotic syndrome associated with malignant thymoma have been reported in Korea and in Western countries. [11,14] In early reports, nephrotic syndrome developed several years after thymectomy or other treatments in a majority of cases. [11,15] However, additional reports have indicated that treatment for nephrotic syndrome preceded the diagnosis of thymoma.…”

Section: Discussionmentioning

confidence: 99%

“…[11,15] However, additional reports have indicated that treatment for nephrotic syndrome preceded the diagnosis of thymoma. [14] In a systematic review of reported cases of minimal change disease and solid malignant tumors, including thymoma, [16] nephrotic syndrome and malignant thymoma were simultaneously diagnosed in only 20% of the cases, whereas nephrotic syndrome was diagnosed after the diagnosis of thymoma in 65% of the cases. Besides minimal change disease, which is the most common pathologic type of nephrotic syndrome associated with thymoma, focal segmental sclerosis, membranous nephropathy, and membranoproliferative glomerulonephritis are also associated with malignant thymoma.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nephrotic syndrome associated with metastatic thymoma treated with chemotherapy

Yoo

Kim

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Nephropathy with concurrent invasive thymoma is a type of paraneoplastic syndrome.Patient concerns and Diagnoses:We report a 32-year-old female with nephrotic syndrome that was first diagnosed along with invasive thymoma and treated by means of cisplatin-based chemotherapy for the thymoma. The patient initially presented with dyspnea and generalized edema. Chest radiography and computed tomography scans revealed right pleural effusion and a mass in the right middle lung field, which were confirmed by a percutaneous lung biopsy as metastatic invasive thymoma. Severe hypoalbuminemia, heavy proteinuria, hyponatremia, and hypercholesterolemia were features of the nephrotic syndrome. A kidney needle biopsy suggested focal segmental glomerulosclerosis.Interventions and Outcomes:All of the symptoms of nephrotic syndrome were resolved simultaneously during the first 2 cycles of chemotherapy. The patient was on regular follow-up with no specific treatment for nephrotic syndrome and underwent successful resection of the left pleura and anterior thymoma. The patient has shown no evidence of recurrence for 2 years.Lessons:We conclude that chemotherapy for invasive thymoma is an effective treatment for nephrotic syndrome accompanying the thymoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nephrotic syndrome associated with metastatic thymoma treated with chemotherapy

Yoo

Kim

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…In humans, the nephrotic syndrome is an infrequent parane oplastic condition associated with thymoma; in a review of 960 cases, two had concurrent nephrotic syndrome (Rosenow and Hurley, 1984). Schillinger, et al, 1997, reviewed the renal lesions of twenty cases of human thymoma associated with nephrotic syndrome, and found that all were associated with glomerulopathy. Based on the high frequency of elevated antinuclear antibodies and myasthenia gravis in these patients, an autoimmune pathogenesis was suggested (Schillinger, et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Schillinger, et al, 1997, reviewed the renal lesions of twenty cases of human thymoma associated with nephrotic syndrome, and found that all were associated with glomerulopathy. Based on the high frequency of elevated antinuclear antibodies and myasthenia gravis in these patients, an autoimmune pathogenesis was suggested (Schillinger, et al, 1997). Advanced chronic renal disease in the end-stage kid ney o f the cu rren t case m ay have m asked m orphologic evidence of a primary glomerular injury.…”

Section: Discussionmentioning

confidence: 99%

Renal Failure and Bilateral Thymoma in an American Bullfrog, Rana catesbiana

Jacobson

Robertson

Lafortune

et al. 2004

Journal of Herpetological Medicine and Surgery

View full text Add to dashboard Cite

An adult female American bullfrog, Rana catesbiana, from a zoological collection, was examined because of a slowly progressive distension of the coelomic cavity. Approximately 750 cc of clear fluid was removed by celiocentesis. Using cardiocentesis, a blood sample was obtained and plasma was removed for biochemical analyses. The frog was kept in a isotonic solution of saline that contained calcium gluconate, and enrofloxacin was administered orally for 17 d. The frog was found dead in its cage at 17 d following removal of the coelomic fluid and was submitted for necropsy. Major gross findings were cystic kidneys and bilateral cystic masses in the cervical region. Using light microscopy, glomeruli were swollen and were surrounded by thick rims of dense fibrous connective tissues; some also were sclerotic. Additionally there was chronic, dif fuse, severe tubulointerstitial nephritis. The bilaterally symmetrical cystic masses in the cervical region had microscopic features most consistent with those of the thymus and the diagnosis was thymoma. This repre sents the first report of chronic renal disease and thymoma in an amphibian.

show abstract

“…Occasionally, such a relationship can be seen even in patients with thymoma, which is a common neoplasm of the anterior mediastinum arising from thymic epithelial cells ( 2 - 4 ). Nephrotic syndrome may either precede or act as the presenting feature of the disease, although there is often a substantial time interval between the 2 conditions, with renal manifestations occurring in approximately half of all cases 8 to 180 months after the curative treatment of thymoma, primarily based on surgical resection with radiotherapy ( 5 - 7 ).…”

Section: Introductionmentioning

confidence: 99%

Nephrotic Syndrome and a Retroperitoneal Mass: A Case Report of a Patient with Recurrent Invasive Thymoma

et al. 2017

View full text Add to dashboard Cite

A 68-year-old man was admitted to our hospital to undergo an examination for nephrotic syndrome while concurrently complicated with recurrent thymoma in the parietal pleura and retroperitoneum. He had been diagnosed with invasive thymoma and had undergone thymo-thymectomy seven years previously. Based on the renal biopsy findings, his nephrotic syndrome was ascribed to minimal change disease. He was treated with corticosteroid monotherapy, which resulted in complete remission six months later, despite the fact that the recurrent thymoma remained. The role of thymoma in the pathogenesis of paraneoplastic glomerulopathy and the therapeutic concerns that emerged in this case are also discussed.

show abstract

Nephrotic syndrome as the presenting feature of malignant thymoma

Cited by 13 publications

References 1 publication

Nephrotic syndrome associated with metastatic thymoma treated with chemotherapy

Nephrotic syndrome associated with metastatic thymoma treated with chemotherapy

Renal Failure and Bilateral Thymoma in an American Bullfrog, Rana catesbiana

Nephrotic Syndrome and a Retroperitoneal Mass: A Case Report of a Patient with Recurrent Invasive Thymoma

Contact Info

Product

Resources

About