Nephroprotective effect of Paeonia emodi via inhibition of advanced glycation end products and oxidative stress in streptozotocin–nicotinamide induced diabetic nephropathy

Abstract

The present study aimed to evaluate the effect of alcohol (PA) and hydroalcohol (PHA) extract of Paeonia emodi Royale roots in treatment of streptozotocin-nicotinamide induced diabetic nephropathy. Diabetes mellitus was induced in male Wistar rats by streptozotocin (65 mg/kg intraperitoneally) 15 minutes after nicotinamide (230 mg/kg, intraperitoneally) administration and diabetic nephropathy was assessed by measuring serum glucose, renal parameters (urea, uric acid, creatinine, and blood urea nitrogen level) and lipid profile. The rats were treated with different doses of extracts (100 mg/kg, 200 mg/kg, and 400 mg/kg) for 45 days. Oxidative stress was assessed by measuring tissue antioxidant enzymes level along with the formation of advanced glycation end-products (AGEs) in kidney. PA and PHA (400 mg/kg) produced significant attenuation in the serum glucose level (165.08 ± 3.353 mg/dL and 154.27 ± 2.209 mg/dL, respectively) as compared to control. Elevated renal parameters, lipid levels, tissue antioxidant enzymes and AGE formation were also restored in a dose-dependent manner. These findings suggest that by amelioration of oxidative stress and formation of AGEs, PA and PHA significantly inhibited the progression diabetic nephropathy in rats.

Dillenia indica L. attenuates diabetic nephropathy via inhibition of advanced glycation end products accumulation in STZ-nicotinamide induced diabetic rats

“… 52 AGEs accumulation is the only mechanism that leads to structural aberrations in kidneys of DN animals. 11 , 50 , 53 Inhibition of the formation of AGEs is a potentially therapeutic avenue in DN. The present study demonstrates that DAE and DHE exhibits potential inhibitory effect against the formation of AGEs in vitro .…”

Antidiabetic, hematoprotective and nephroprotective effects of the aqueous extract of Falcaria vulgaris in diabetic male mice

“…F. vulgaris as a medicinal plant rich in antiinflammatory and antioxidant compounds such as spathulenol, carvacrol, alpha-pinene and limonene, and it has strong antiinflammatory and antioxidant properties [20,53,54]. Previous studies have indicated that ethnomedicinal plants rich in antiinflammatory and antioxidant compounds decrease weight, volumes and lengths of kidney and its subcomponents in STZ-induced nephrotoxicity in mice [55,56].…”

Effects of Gui Zhi Ma Huang Ge Ban Tang on the TLR7 Pathway in Influenza Virus Infected Mouse Lungs in a Cold Environment

“…Ginger contains gingerol, which can inhibit production of nitric oxide, IL-6, and TNF in glial cells. Peony [ 32 ], Guizhi [ 33 ], and ginger have anti-inflammatory effects and can reduce expression of PGE2, NF- κ B, and other mediators of the inflammatory response. The chemical constituents in Gui-Zhi-Tang [ 34 ] were studied by rapid resolution liquid chromatography quadrupole time-of-flight mass spectrometry combined with rapid resolution liquid chromatography-diode array detector-ion trap mass spectrometry, and a total number of 187 compounds were detected.…”