Nephroprotective activity ofMomordica dioicaRoxb. in cisplatin-induced nephrotoxicity

Abstract

In this study, the ethanol extract of Momordica dioica fruit extract (200 mg kg(-1)) was studied for nephroprotective and curative activities. Chloroform, ethyl acetate, ethanol and aqueous extracts were prepared. In vitro antioxidant activity was made the basis for the selection of the ethanol extract for further studies. In DPPH free radical scavenging activity, the ethanolic extract has shown maximum inhibition (84.2%), followed by aqueous (74.8%), ethyl acetate (69.4%) and chloroform (59.7%) extract. On the other hand, in total antioxidant activity, the ethanol extract has shown 80.1% inhibition, followed by aqueous (71.9%), ethyl acetate (67.2%) and chloroform (53.2%) extracts. A single dose (5 mg kg(-1), i.p.) of cisplatin was administrated to induce nephrotoxicity. Blood urea and serum creatinine were analysed as biochemical markers of nephrotoxicity. Reduced glutathione (GSH) and the product of lipid peroxidation (MDA) were also measured in kidney tissues. A single dose of cisplatin resulted in significant reduction in body weight and increased the urea and creatinine levels. Extract administration has shown significant recovery in the levels of these biochemicals in curative (p < 0.001) and protective groups, whereas a single dose of cisplatin caused significant reduction in GSH and an increase in malondialdehyde production. Recovery was observed in treated groups. This study suggested that the nephroprotective and curative activities of M. dioica fruit extract are due to its antioxidant activity. It is further concluded that this antioxidant activity may be attributed to the phenolics, flavonoids and amino acids present in the extract.

Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats

“…However, there J o u r n a l P r e -p r o o f is no evidence that M. dioica fruits have anti-diabetic properties, even though some researchers claim that M. dioica fruits have hypo/anti-hyperglycemic properties [11][12][13][14][15]. It was also reported to have antioxidant activity [16,17], antimicrobial activity [18,19], hepatoprotective activity which supports our experiment [16,[20][21][22], Reno protective activity [15,23], analgesic and anti-inflammatory activity [24,25].…”

Phytochemical, Phytotherapeutical and Pharmacological Study of Momordica dioica

“…The nephroprotective and curative activities of its fruit extract ware also observed [53]. Gupta et al evaluated the renal protective effect of Momordica dioica extract in streptozotocin-diabetic rats [54].…”

Anti-Allergic Effects of Kakrol (<i>Momordica dioica</i> Roxb.) Flesh Extract

“…It is a species related to bitter gourd ( Momordica charantia Linn), which is nigauri in Japan. Kakrol, rather than nigauri, has generally been used in dishes because it has a sweet taste and contains a larger content of ascorbic acid than nigauri [5, 6]. …”

“…In addition, ethanol and water extracts of kakrol fruit not only have nephroprotective activity [6, 7] but also have hepatoprotective activity [8]. However, there is no study about the anti-allergy activity of kakrol extract.…”