Nephropathie durch Analgetica

Gsell, O

doi:10.1007/978-3-642-65879-2_3

Cited by 5 publications

(3 citation statements)

References 156 publications

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“…Papillary necrosis is known to be caused by chronic postrenal obstruction, reflux nephropathy, diabetes mellitus, and sickle-cell anemia [105,175]. After these factors are excluded, analgesic abuse is the classic cause of renal papillary necrosis [25,44,45,93,94,101,106,118,120,140,168,169,180,262,284]. Several studies on the correlation between renal papillary necrosis and analgesic abuse have been reported.…”

Section: Analgesic Abuse and Renal Papillary Necrosismentioning

confidence: 99%

Analgesic-associated nephropathy

Schwarz

1987

Klin Wochenschr

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Although the question of whether or not analgesic abuse leads to a certain type of nephropathy has been investigated since 1953, no conclusive answer has been forthcoming. Epidemiologic investigations on the correlation between analgesic abuse and renal function as well as experimental animal studies have given contradictory results concerning the possibility of analgesic-associated kidney damage. However, studies on the correlation between analgesic abuse and papillary necrosis have demonstrated that this lesion coincides in 69% of the cases with an analgesic history. Follow-up studies of patients with analgesic nephropathy have shown that renal function deteriorates in 60% of the patients with continued abuse and that it stabilizes in 80% of the patients after cessation of abuse. Studies on the legislative restriction of phenacetin/acetaminophen, carried out mostly in Scandinavian countries since 1965, show a 50%-90% decline in signs of analgesic nephropathy (papillary necrosis) following a reduction in the sale of these drugs. The prevalence of analgesic abuse may be underestimated, since up to 80% of the abusers tend to deny their analgesic intake. Obviously, only a small percentage of analgesic abusers (approximately 1%) finally develop nephropathy. Even though the results of epidemiologic and experimental studies are contradictory, the results of investigations on papillary necrosis and on legislative prevention as well as of patient follow-ups tend to indicate a correlation between analgesic abuse and a well-defined type of nephropathy.

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Section: Analgesic Abuse and Renal Papillary Necrosismentioning

confidence: 99%

Analgesic-associated nephropathy

Schwarz

1987

Klin Wochenschr

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“…Bedeutung für die Karzinogenese zuerkannt (3, 4, 7, 10,15,19,22,23,34). Der Phenacetinmetabolismus ist inzwischen geklärt (9,38,39) und ist in seinen wesentlichen Schritten schema tisch in Abb.…”

Section: Key-words: Phenacetin Abuse Renal Pelvic Tumours -Clinical Runclassified

Nierenbeckentumoren und Phenacetinabusus

Leistenschneider¹,

Nagel²,

Steffens³

1983

Aktuel Urol

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“…Phenacetin abuse is generally defined as ingestion of either 1 g phenacetin daily over a period of 3 years or a total dose of 1 kg phenacetin [10,22]. The incidence of CS in our study (i.e.…”

Section: Discussionmentioning

confidence: 99%