Nephrogenic adenoma of the urinary bladder

Abstract

Unlike histological features, the clinical--endoscopic characteristics of NA are non-specific. Even if it is not definitely considered like a premalignant condition, NA has to be followed up frequently and long lasting, because of its high recurrence rate. The combination of Cytology, Flow cytometry, DNA image analysis and Fluorescence in situ hybridisation of bladder washings or voided urine, are of high value in monitoring NA of the urothelium.

Multifocal Nephrogenic Adenoma of the Bladder in a Pediatric Patient

“…8,12,14 Although not premalignant, frequent follow-up is mandatory because of a high recurrence rate. 7 Nephrogenic adenomas are benign tumorlike lesions within the urothelial mucosa of the urinary tract. Of some interest, these lesions are not uncommon in renal transplant recipients.…”

Do We Need Surveillance Urethro-Cystoscopy in Patients with Neurogenic Lower Urinary Tract Dysfunction?

“…Although our patient with bladder melanosis suffered from NLUTD due to cerebral palsy, it is unknown, if there is a causal relationship between NLUTD and the development of bladder melanosis or if it is just a coincidental histological finding. Nephrogenic adenoma ( Fig 2 ) is an uncommon metaplastic lesion of the urothelium found in all locations of the urinary tract often with multifocal appearance and most commonly seen in the urinary bladder [ 22 , 23 ]. Etiology and biological potential are still unclear, but it seems to be attributed to urothelial irritation by trauma, previous surgery, urinary calculi, radiation, chronic infections and urinary catheterization [ 22 , 23 ].…”

“…Nephrogenic adenoma ( Fig 2 ) is an uncommon metaplastic lesion of the urothelium found in all locations of the urinary tract often with multifocal appearance and most commonly seen in the urinary bladder [ 22 , 23 ]. Etiology and biological potential are still unclear, but it seems to be attributed to urothelial irritation by trauma, previous surgery, urinary calculi, radiation, chronic infections and urinary catheterization [ 22 , 23 ]. Clinical symptoms, when present, are non-specific such as lower urinary tract symptoms and hematuria [ 22 , 23 ].…”

Nephrogenic Adenoma of the Ureter

“…4,5 The most common clinical presentations of NA are: previous surgery, trauma, chronic urinary tract infections, and/or recurrent urolithiasis. 1,4 Although NA appears with hematuria or obstruction, it is frequently found incidentally in endoscopy or imaging modalities. 6 It may mimic malignancy radiologically with mass image and filling defect.…”

“…The incidence in ureter is approximately 4%. 1 Firstly, it was defined by Davis with the name hamartoma. 2 Later it was named nephrogenic adenoma because of the tubular structures in the lesion.…”