Nephrogenic adenoma of the urinary bladder and urethra

Bhagavan, Belur S.; Tiamson, Esperanza M.; Wenk, Robert E.; Berger, Bruce W.; Hamamoto, Gary; Eggleston, Joseph C.

doi:10.1016/s0046-8177(81)80196-7

Cited by 62 publications

(25 citation statements)

References 16 publications

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“…It may be associated with transitional cell cacinoma, adenocarcinoma and squamous cell carcinoma of the urinary bladder [11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…These structures are covered by a single layer of cuboidal or cylindrical cells with clear or eosinophilic cytoplasm and bland nuclei [12,32]. NA may present with cellular atypia with pseudoinfiltrative growth, giving rise to difficulties in the differential diagnosis and is often associated with adjacent areas of squamous or mucinous metaplasia (cystitis glandularis) [33].…”

Section: Discussionmentioning

confidence: 99%

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Nephrogenic Adenoma of the Urinary Bladder: Our Experience and Review of the Literature

Porcaro¹,

D’Amico²,

Ficarra³

et al. 2001

Urol Int

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Objective: To assess our experience in the treatment and clinical outcome of bladder nephrogenic adenoma (NA) updating and reviewing the literature concerning this issue. Patients and Methods: From September 1976 to June 1999, bladder NA was diagnosed in 8 patients: 6 men and 2 women with a 3:1 male ratio, aged 26–80 (mean 58.3) years. Follow-up ranged from 4 to 194 (mean 93.5) months. Results: NA was associated with transitional cell carcinoma in 3 cases. Predisposing factors were assessed in all patients. Previous surgery of the lower urinary tract was detected in 5 cases: ureterocystoneostomy in 2, partial cystectomy in 1, repair of vesicouterine fistula in 1, and multiple urethroplasties in 1. Previous endoscopic treatments were carried out in 2 patients, transurethral resection of the prostate in 1 and repeated transurethral resection of the vesicle in the other. A history of intravesical instillation of bacillus Calmette-Guérin was assessed in 1 case. Patients complained of irritative voiding symptoms in 6 cases and hematuria in 2. Endoscopically, the lesions appeared polypoid and multifocal in 5 patients, and flat and single in 3. The lesions were removed endoscopically, providing relief of symptoms in all cases. Histopathology assessed the diagnosis of nephrogenic adenoma, detecting focal atypic cells in 1 case only. Five patients (63%) relapsed 2–24 months after management. Recurrences were also treated endoscopically. Conclusions: Clinical and endoscopic features of bladder NA are not specific, simulating urothelial carcinoma or chronic cystitis. Endoscopic management allows accurate histological diagnosis and provides long-lasting relief of symptoms. NA needs careful and long-term follow-up, because of the high risk of recurrences and the potential neoplastic degeneration of the metaplastic urothelium.

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“…It may be associated with transitional cell cacinoma, adenocarcinoma and squamous cell carcinoma of the urinary bladder [11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nephrogenic Adenoma of the Urinary Bladder: Our Experience and Review of the Literature

Porcaro¹,

D’Amico²,

Ficarra³

et al. 2001

Urol Int

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“…3 The clinical presentation can vary from a triad of dysuria, postvoid dribbling, and dyspareunia associated with urethral diverticula to nonspecific urinary complaints to being an incidental finding. 5,10 The recommendation for management is resection. 4 Whether NA is a premalignant condition has been raised multiple times in the literature.…”

Section: Discussionmentioning

confidence: 99%

Nephrogenic Adenoma in a Urethral Diverticulum

Gujral

Chen²,

Ferzandi³

2014

Female Pelvic Medicine &Amp; Reconstructive Surgery

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Nephrogenic adenoma (NA) is a rare finding that represents metaplasia of the urothelium. We present a case of a 46-year-old woman who presented with a symptomatic anterior vaginal wall cyst that was found to be an NA within a urethral diverticulum. Although this remains an infrequently reported entity in the literature, prevalence has been shown to be higher in consecutive case series than what may be presumed by the rarity of case reports in clinical literature. Nephrogenic adenoma within a urethral diverticulum may represent an under-recognized entity which needs to be carefully distinguished from clear cell adenocarcinoma occurring within urethral diverticula. We discuss salient clinical features of NA occurring within a urethral diverticulum and describe a review of literature of published cases to date.

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“…The term 'nephrogenic adenoma' was minted by Friedman and Kuhlenbeck [5] in 1950: with this term the authors stressed the histologic pattern of the lesion comprising of epithelial tubules in the lamina propia of the bladder that strictly resembled portions of a nephron. From these first reports, several cases occurring throughout the urinary tract have been described in the literature [1,2,6,8,[12][13][14][15], The etiology of the lesion is still debated. Theories include embriologic [10], inflam matory [14] and immunosuppressive [6] origin.…”

Section: Discussionmentioning

confidence: 99%