Nephrogenic Adenoma of the Urinary Bladder

Zougkas, K.; Kalafatis, Marinos; Kalafatis, Panagiotis

doi:10.1007/s11255-005-2086-z

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…Many specialists suggest that NA is an atypical response from the site of the regenerating epithelium due to stimulus or injury. [7] Presentation in children represents only a small proportion of NA cases. NA appears most commonly in middle-aged males.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Cystoscopy provides the initial visual diagnosis in suspicion of transitional cancer. [7] Macroscopic presentations in cystoscopy consist of papillary (56%), flat (34%), and polypoid (10%) lesions NA appears like a low-grade TCC. Its common localization is on the bladder wall; and generally lesions are less than 1 cm in size and limited up to 7 cm.…”

Section: Discussionmentioning

confidence: 99%

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Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Özçift

Kaçar

Tiryaki

2016

Turkish Journal of Urology

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Nephrogenic adenoma (NA) is a rarely seen benign metaplastic lesion of the urinary tract. Its etiology is uncertain, but induced by chronic inflammation, irritation, and trauma. NA is located in the urinary tract, most commonly in the bladder. NA usually presents with hematuria and lower urinary tract symptoms. In the literature it is mostly seen in adults but about 30 cases of NA's have been reported in children. Treatment of intravesical lesions consists of transurethral resection (TUR) and fulguration and rarely partial or total cystectomy may be required in ineffective TUR. Recurrence rate is high during long-term follow-up. The intravesical application of sodium hyaluronate produces a protective effect on the glycosaminoglycan layer and delays or prevents its recurrence. We report a case of recurrent NA of the bladder in a pediatric male patient who was presented four years after previous surgery despite intravesical sodium hyaluronate therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Özçift

Kaçar

Tiryaki

2016

Turkish Journal of Urology

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“…Nephrogenic adenoma may appear on ultrasonography, i.v. pyelogram, and voiding cystourethrogram as a filling defect . Cystoscopically NA has been reported to look like a papillary (55%), sessile (35%) or polypoid (10%) mucosal mass.…”

Section: Discussionmentioning

confidence: 99%

“…Micro‐ or macro‐hematuria are present in 40% of cases and suprapubic or flank pain in 15% and 5%, respectively. Tumor recurrence develops in 80% of children with a latency period of 4 years . With respect to high recurrence rates, there have been no reported cases of malignant transformation or metastatic disease in pediatric patients …”

Section: Discussionmentioning

confidence: 99%

Rare cause of macroscopic hematuria in a pediatric patient: Nephrogenic adenoma of the bladder

Göknar

Sılay

Tosuner

et al. 2014

Pediatrics International

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“…These lesions can undergo open resection if they present as large, vegetative vesical masses, or they may undergo endoscopy if they are sufficiently small and in the bladder or urethra. Nevertheless, they can recur, especially with regard to vesical localization, if they are located in the urethra; such patients have complained of dysuria, suggesting continuity of the lesions [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Nephrogenic Adenoma In the Prostatic Urethra and In the Ureter: Urothelial Lesions Associated with Chronic Infections and Injures In the Urinary Tract

Roca¹,

Lamacchia²,

Silva³

et al. 2012

UIJ

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Purpose: To report our findings on urothelial lesions diagnosed as nephrogenic adenomas and determine the importance of a correct clinical and anatomopathological interpretation. Materials and Methods: We report the surgical and anatomopathological findings for 3 cases involving nephrogenic adenoma into the urothelium. One case was in the prostatic urethra of an 84-year-old male who underwent suprapubic prostatectomy due to benign prostatic hyperplasia. Another one was microscopic, and in the lumen of a 4 cm proximal ureteral stenosis of a 30-year-old man due to a ureteral perforation during an ultrasonic ureterolithotripsy 18 months prior. After repeated (6) transureteral endoscopic manipulations, always stented with a double-J ureteral catheter, we finally performed an excision of the ureteral stenotic segment and end-to-end ureteroureteral anastomosis. The final case was in a 5-year-old female, exhibiting recurrent urinary infections and renal lithiasis, who presented with a polypoid lesion in the proximal ureter that we detected and resected by ureteroscopy. Results: In the oldest male patient, who underwent surgical manipulation with repeated vesical catheterizations and experienced recurrent urinary infections, the microscopic exam revealed benign prostatic hyperplasia and an incidental lesion 1 cm in diameter in the prostatic urethra with pathological characteristics of nephrogenic adenoma. In the youngest male, the nephrogenic adenoma was incidentally found as a microscopic lesion in the ureteral fibrotic lumen. In the child's case, she underwent an ultrasonic percutaneous nephrolithotripsy due to a voluminous renal calculus, which later resulted in residual obstructive renal calculi at the pyeloureteral junction that necessitated ureteroscopy for nephrocutaneous fistula. It was then that a 0.8 cm polypoid lesion was observed in the proximal ureter during implantation of a double-J ureteral catheter, which was resected and diagnosed as nephrogenic adenoma. Conclusion: In areas of the urinary tract that have experienced recurrent urinary infections or traumas, or have undergone surgical manipulation, polypoid lesions can develop or appear microscopically. These lesions do not promote such chronic alterations but could result from them, likely due to cellular implants of renal tubules in areas of the urothelium in which the implantation is suitable and are recognized by microscopy as benign urothelial processes. Although such findings are rare, they likely occur more frequently than believed.

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Nephrogenic Adenoma of the Urinary Bladder

Cited by 9 publications

References 18 publications

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Rare cause of macroscopic hematuria in a pediatric patient: Nephrogenic adenoma of the bladder

Nephrogenic Adenoma In the Prostatic Urethra and In the Ureter: Urothelial Lesions Associated with Chronic Infections and Injures In the Urinary Tract

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