Nepeta humilis Bentham: First evaluation of phenolic profile and radical scavenging potential

Abstract

In traditional medicine, Lamiaceae plants are widely used as a cure for various health problems. Nepeta humilis is one of the Lamiaceae plants of Iranian-Turkish district growing naturally in the South East Anatolia. The present study was designed to investigate the radical scavenging activity and total phenolic content of Nepeta humilis as well as to determine the phenolic constituents of the extracts of flowers, leaves and roots using a previously validated RP-HPLC-DAD method for the first time. The total phenolic contents of flowers, leaves and roots were found as 123.18 ± 1.01, 66.20 ± 0.49 and 54.77 ± 1.23 mg GAE/g extract, respectively. In accordance with the higher total phenolic content, flower extract of the plant displayed more radical scavenging activity with both assays. HPLC results revealed that rosmarinic acid was detected as one of the main compounds in all the investigated parts of the plant, especially in the flowers (0.397 ± 0.01 g/100g dry weight). Also, chlorogenic acid, luteolin and apigenin were found in particular amount in the flower extract. Nepeta humilis is rich in phenolic compounds and can be evaluated as a promising antioxidant source.

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

“…In addition, the concentration of the different components in the methanol and water extracts might be different, and this was not specified in our data. In accordance with our results, the presence of flavones and hydroxycinnamic acid in the members of the Nepeta genus was reported in earlier studies [23][24][25][26][27].…”

Cytotoxic Effects of Some Nepeta Species against Breast Cancer Cell Lines and Their Associated Phytochemical Properties

“…Similarly, an investigation about analysis of N. humilis extracts with RP-HPLC-DAD showed that the major component in all parts of the plant, especially in flowers, is rosmarinic acid, while flowers contain phenolic compounds such as chlorogenic acid, luteolin and apigenin [ 38 ].…”

Essential oil composition of two endemic Nepeta L. (Lamiaceae) taxa from Southwestern Turkey

“…It is a member of the tribe Mentheae (subfamily Nepetoideae) and includes about 300 species (Asgarpanah et al, 2014). In Turkey, there are 40 taxa in the Nepeta genus, 16 of which are endemic (Gökbulut & Yılmaz, 2020). Nepeta species are commonly utilized in traditional medicine by the local people, primarily as spasmolytic, diuretic and bronchodilator agents (Sharma et al, 2021).…”