Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil

Vieira, Anahi S.; Azevedo, Maria Isabel Nogueira Di; D’Andrea, Paulo Sérgio; Vilela, Roberto do Val; Lilenbaum, Walter

doi:10.1016/j.rvsc.2019.04.001

Cited by 10 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Argentina. Furthermore, the finding of pathogenic leptospires in the kidney of some of these rodent species suggests that they may be shedding the bacteria to the environment [7,[10][11][12]. Both rats (Rattus novergicus and R. rattus) tested positive for IgG antibodies, while none of the 11 M. musculus were seropositive.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

“…Murid rodents of the species Mus musculus, Rattus norvegicus and Rattus rattus (Muridae: Murinae) are maintenance hosts of the serovars Icterohaemorrhagiae, Copenhageni and Ballum [4,5]. In recent years, some species of South American sigmodontine rodents (Cricetidae: Sigmodontinae) were also reported as renal carriers of Leptospira [6][7][8][9][10][11][12]. Introduced and native rodent species usually cohabit and seek food and shelter in the proximity of households, becoming an important source of infection for humans and domestic animals [4,6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

et al. 2020

View full text Add to dashboard Cite

Background Leptospirosis is a zoonotic disease that can be transmitted by contact with the urine of infected mammals. Rodents play a mayor role in the transmission of leptospires to humans. The province of Santa Fe reports the greatest number of cases in Argentina. Yet, in this region, there are still knowledge gaps regarding the diversity of rodent species that may be hosts of pathogenic leptospires. The aims of this study were to evaluate the presence of leptospiral antibodies in rodents from three riverside communities of Santa Fe, and to identify factors associated with leptospiral infection. Methodology/Principal findings Each community was divided into three environmental settings based on the level of human disturbance, and sampled during two springs (Sep-Oct 2014 and 2015) and one autumn (Mar-Apr 2015). Serum samples of captured sigmodontine and murine rodents were tested for leptospiral antibodies by enzyme-linked immunosorbent assay (ELISA), and microagglutination test (MAT) was used to assess the infecting serovar in seropositive individuals. Factors influencing seropositivity were analyzed using logistic regression models. We caught 119 rodents, of which 101 serums were suitable for analysis. Most frequently trapped species were Scapteromys aquaticus, Akodon azarae and Oligoryzomys spp., with seroprevalences of 41.3%, 42.9% and 55% respectively. Seropositivity was higher in individuals with an average body condition score and in those that were sexually mature, but in the latter the differences were marginally significant.

show abstract

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, changes in these habitats have allowed for greater anthropic interaction of southern tamanduas with humans and domestic animals. Environmental anthropization contributes to the greater circulation of pathogens, including leptospires, among humans, domestic animals, and free‐roaming animals (Vieira, Di Azevedo, D'Andrea, do Val Vilela, & Lilenbaum, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The zoo is located in an urban area. This characteristic facilitates contact of wild animals with domestic animals and synanthropes, predisposing these wild animals to pathogen transmission (Vieira et al, 2019). In addition, leptospirosis is a reemerging infectious disease and represents a public health problem in suburban centres of developing countries, particularly in Brazilian.…”

Section: Introductionmentioning

confidence: 99%

“…Prior literature has mentioned that southern tamanduas are susceptible to leptospirosis (Diniz, Costa, & Oliveira, 1995). However, these claims were based on anti‐ Leptospira antibody titres (Vieira et al, 2019) and did not include any reports of deaths of southern tamanduas affected by leptospirosis. To our knowledge, this article provides the first report of mortality caused by Leptospira sp.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Leptospira interrogans infection of southern tamanduas ( Tamandua tetradactyla , Linnaeus, 1758) in Brazil

Silva

Azevêdo

Júnior

et al. 2020

Transbound Emerg Dis

View full text Add to dashboard Cite

Leptospirosis is a zoonotic disease of global importance caused by an obligate aerobic spirochaete that infects a wide variety of domestic and wild animals. Natural hosts are asymptomatic or show moderate signs of the disease. Accidental hosts develop a severe, often lethal, form of the disease. All young southern tamanduas died suddenly at the zoo in the city of João Pessoa, Brazil. The animals were found dead without any noticeable clinical signs. Necropsy revealed extensive haemorrhage in the subcutaneous tissues, kidneys, lungs in addition to the presence of red fluid in the thoracic, abdominal and pericardial cavities. Histopathology of kidneys exhibited acute interstitial nephritis and tubular necrosis. Immunohistochemical staining revealed typical leptospiral wavy forms and aggregates in the lumen of several kidney tubules and lungs. Pathological and molecular investigations confirmed Leptospira interrogans infection. The adult tamanduas did not present with clinical alterations. To our knowledge, this investigation is the first study to report that leptospirosis should be considered as a possible cause of death in tamanduas. This article warns of the risks of anthropization with respect to Leptospira transmission to tamanduas, other animals and humans.

show abstract

The influence of sugarcane pre‐harvest fire on hantavirus prevalence in Neotropical small mammals

et al. 2022

View full text Add to dashboard Cite

The use of pre-harvest fire in sugarcane fields surprisingly results in an increase in the abundance of Neotropical Sigmodontinae rodents, which might carry hantavirus. By contrast, fire suspension induces a decline in rodents in the first 5 years. The present study aimed to evaluate the effect of sugarcane harvest regimes on hantavirus prevalence in wild rodents. Field collections were carried out on a sugarcane production area in Northeast São Paulo, which is responsible for 30% of the ethanol production in Brazil. A few years after pre-harvest fire suspension, a high prevalence of hantavirus was found in small rodents at lower population density, but apparently higher population growth rate. Differences in life cycle between the rodents and their predators may explain such density patterns, as small rodents can breed twice or even three times each year, whereas their predators usually breed only once a year. Similarly, the temporal dynamics of the predator-prey relationship suggests that hantavirus prevalence is related to small rodent's population growth and not density. Only Akodon montensis, Calomys tener, and Necromys lasiurus contained immunoglobulin G antibodies

show abstract

Neotropical wild rodents Akodon and Oligoryzomys (Cricetidae: Sigmodontinae) as important carriers of pathogenic renal Leptospira in the Atlantic forest, in Brazil

Cited by 10 publications

References 25 publications

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

Leptospira interrogans infection of southern tamanduas ( Tamandua tetradactyla , Linnaeus, 1758) in Brazil

The influence of sugarcane pre‐harvest fire on hantavirus prevalence in Neotropical small mammals

Contact Info

Product

Resources

About