Neopterin levels and left ventricular dysfunction in patients with chronic stable angina pectoris

Estévez‐Loureiro, Rodrigo; Recio-Mayoral, Alejandro; Sieira-Rodríguez-Moret, Juan A.; Trallero-Araguás, Ernesto; Kaski, Juan Carlos

doi:10.1016/j.atherosclerosis.2009.04.032

Cited by 20 publications

(14 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Growing evidence indicates a role of NPT in cardiovascular risk stratification. NPT has been indicated as a predictor of LV dysfunction in patients with chronic stable coronary artery disease (36). It was associated with mortality among survivors of an acute myocardial infarction (15) and with an increased cardiac event rate in patients with heart failure (21).…”

Section: Discussionmentioning

confidence: 99%

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

et al. 2015

View full text Add to dashboard Cite

Objective:Available evidence suggests that inflammation may be associated with atrial fibrillation (AF). This prospective and observational study aimed to assess whether plasma neopterin (NPT) and interleukin-6 (IL-6) levels before and after electrical cardioversion (CV) predict AF recurrence.Methods:The study was designed as a prospective observational trial. Blood samples were collected (24 hours before, 24 h after CV, and 7 days after CV) in 60 patients with a dual-chamber pacemakar and preserved left ventricular systolic function who underwent successful CV of persistent AF. All significant parameters associated with AF recurrence lasting ≥30 min and detected by pacemaker data logs were evaluated in multivariate logistic regression analysis. Echocardiography was performed 7 days after CV in patients with sinus rhythm. The control group included 17 subjects without AF.Results:The analysis included 51 patients who remained in sinus rhythm 7 days after CV. During 12 months of follow-up, AF recurred in 46 patients. Baseline IL-6 levels did not differ between the two groups, but baseline NPT levels were higher in the study group than in the control group (19±7 vs. 11±5 nmol/mL, p<0.001). NPT levels of ≥14.6 nmol/L at baseline and ≥13.3 nmol/L 7 days after CV separated the patients with AF recurrence from those without arrhythmia after CV. Only left atrial emptying fraction <38% was an independent predictor of AF recurrence (p=0.03), whereas NPT levels of ≥13.3 nmol/L 7 days after CV showed borderline statistical significance (p=0.07).Conclusion:Increased NPT level was observed in patients with persistent AF. Neither baseline IL-6 and NPT levels nor their changes within 7 days after CV were predictive of AF recurrence. Further studies are needed to establish the prognostic significance of NPT in patients with AF. (Anatol J Cardiol 2016; 16: 563-71) 0000; 00: 000–000

show abstract

Section: Discussionmentioning

confidence: 99%

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Hence, the importance of neopterin has been highlighted previously as a useful marker for long‐term risk of all‐cause and cardiovascular complications and it could also reflect the status of endothelial function . Recent study reported the increase in neopterin level, even though CRP level did not show any change in patients with left ventricular dysfunction in patients with chronic stable angina pectoris . In one study, Avanzas et al () reported significant association between circulating neopterin levels and number of angiographically complex stenoses in patients with acute coronary syndrome .…”

Section: Resultsmentioning

confidence: 99%

“…Note: *, **, ***: P < 0.05, P < 0.01, P < 0.001 compared with control individuals by one way ANOVA. chronic stable angina pectoris (6,33). In one study, Avanzas et al (2005) reported significant association between circulating neopterin levels and number of angiographically complex stenoses in patients with acute coronary syndrome (5).…”

Section: Resultsmentioning

confidence: 99%

Neopterin: An immune biomarker of coronary artery disease and its association with other CAD markers

et al. 2015

View full text Add to dashboard Cite

Neopterin has been considered as an important marker of cellular inflammation. The primary objective of the current study was to determine the role of neopterin in cardiovascular disease and its association with other well known cardiac markers. The study was composed of total 200 subjects (100 confirmed coronary artery disease (CAD) patients, 50 recently diagnosed, and 50 managed CAD patients) both men and women and 100 healthy control individuals of matching age and weight. Serum neopterin analysis was done using commercial available ELISA kits. Other cardiac markers viz. troponin, creatine kinase (CK), CK MB isoenzyme (CKMB), lactate dehydrogenase (LDH), fibrinogen, C-reactive protein (CRP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) estimation was done by standard routine biochemical methods. Neopterin level was found to be remarkably enhanced by 150% and 513% in the recently diagnosed and managed CAD patients, respectively. CK level also showed a significant rise by 62% in the managed patients. However, recently diagnosed patients did not show any significant change. Moreover, cross correlation study showed statistically significant (P < 0.01) change in neopterin and CK levels between recently and managed patients. In the other studied CAD markers such as CKMB, fibrinogen and LDH also showed a significant increase in both categories of patients. CRP level was also found to be significantly enhanced by 357% (P < 0.01) and 341% (P < 0.05) in recently diagnosed and managed patients respectively. Because of cost effectiveness, easy and quick analysis of neopterin in the serum sample, we propose neopterin as the prognostic as well as diagnostic biomarker of CAD before other markers could be tested especially in Saudi population.

show abstract

“…It is a pteridine derivative and a byproduct of the guanosine triphosphate-biopterin pathway. Neopterin has been studied in the concept of discovering a connection between the inflammatory process and left ventricular (LV) function, as depicted by left ventricular ejection fraction (LVEF) [18]. In recent published data regarding SA patients, increased neopterin levels showed inverse correlation with LVEF values and high neopterin levels were found to be an independent predictive factor for LV dysfunction (LVEF < 45%) (OR 8.52, CI 95% 1.10–65.64; P = 0.040).…”

Section: Biomarkers and Stable Anginamentioning

confidence: 99%

Clinical Usefulness of Novel Serum and Imaging Biomarkers in Risk Stratification of Patients with Stable Angina

et al. 2014

View full text Add to dashboard Cite

Inflammatory mediators appear to be the most intriguing yet confusing subject, regarding the management of patients with acute coronary syndromes (ACS). The current inflammatory concept of atherosclerotic coronary artery disease (CAD) led many investigators to concentrate on systemic markers of inflammation, as well as imaging techniques, which may be helpful in risk stratification and prognosis assessment for cardiovascular events. In this review, we try to depict many of the recently studied markers regarding stable angina (SA), their clinical usefulness, and possible future applications in the field.

show abstract

Neopterin levels and left ventricular dysfunction in patients with chronic stable angina pectoris

Cited by 20 publications

References 35 publications

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

Neopterin: An immune biomarker of coronary artery disease and its association with other CAD markers

Clinical Usefulness of Novel Serum and Imaging Biomarkers in Risk Stratification of Patients with Stable Angina

Contact Info

Product

Resources

About