Neoplastic transformation of Chinese hamster cells in vitro after treatment with flavoring agents.

Kasamaki, Akiko; Yasuhara, Toshio; Urasawa, Shozo

doi:10.2131/jts.12.383

Cited by 23 publications

(7 citation statements)

References 16 publications

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“…Similar mixed results have been observed for mutation induction in E. coli [6,7]. Results of tests in cultured mammalian cells show AITC can induce structural and numerical chromosome changes in several cell lines [4,6,[8][9][10][11][12][13][14][15]. In contrast, AITC has given uniformly negative responses in in vivo tests [16][17][18][19][20][21].…”

Section: Introductionsupporting

confidence: 65%

Lack of UDS activity in the livers of rats exposed to allylisothiocyanate

Bechtel¹,

Henderson

Proudlock³

1998

Teratog. Carcinog. Mutagen.

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Section: Introductionsupporting

confidence: 65%

Lack of UDS activity in the livers of rats exposed to allylisothiocyanate

Bechtel¹,

Henderson

Proudlock³

1998

Teratog. Carcinog. Mutagen.

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“…Additional studies using Salmonella failed to confirm its mutagenicity [107]. However, AITC was mutagenic in an early Drosophila melanogaster sex-linked recessive lethal mutation test [108] and the Chinese hamster B241 cell transformation test [109]. Like most ITCs, AITC is apparently detoxified by nonenzymatic binding to proteins, as bovine serum albumin and human saliva markedly reduced its genotoxicity in the differential DNA repair assay with E. coli cells [110].…”

Section: Mutagenicitymentioning

confidence: 99%

Isothiocyanates as Cancer Chemopreventive Agents: Their Biological Activities and Metabolism in Rodents and Humans

Conaway¹,

Yang²,

Chung³

2002

CDM

374

308

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Isothiocyanates (ITCs) are a group of naturally occurring compounds that occur as thioglucoside conjugates, termed glucosinolates, in plants and cruciferous vegetables such as watercress, Brussels sprouts, broccoli, cabbage, kai choi, kale, horseradish, radish and turnip. ITCs inhibit the development of tumors in many of the experimental models investigated, and are being investigated as possible chemopreventive agents for specific human cancers. The goal of this review is to provide a mechanistic understanding for the biological activities of ITCs and to relate the metabolism of ITCs to their action as chemopreventive agents. In vivo animal studies have been conducted to address issues of tissue disposition, pharmacokinetics, and metabolism of ITCs. Methods for analysis of ITCs and their metabolites in urine and plasma have been developed. The metabolism of several naturally occurring ITCs as constituents of foodstuffs or as drugs has also been investigated in human studies. Finally, based on recent epidemiological studies, the role of dietary consumption of vegetables containing ITCs in prevention of human cancers and human cancer susceptibility is discussed.

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“…Many of the substances that we have described as potential anticarcinogens have also been shown to possess potentially hazardous properties. For example, indole-3-carbinol has been shown to promote carcinogenesis in certain models (Pence et al 1986;Bailey et al 1987) and its toxicology will need to be thoroughly Yamaguchi, 1980Kasamaki et al 1982Dunnick et al 1982Kasamaki et al 1987Kasamaki et al 1982Yamaguchi, 1980Musk &Johnson, 19936 Musk & Johnson, 19936 Kasamaki et al 1982Kasamaki et al 1987Griepentrog, 1973Ishidate et al 1988Takahashi et al 1992Bailey et al 1987Pence et al 1986Maruta et al 1979Musk &Johnson, 19936 Musk & Johnson, 19936 Rueff et al 1992Ishidate et al 1988Suzuki et al 1991Korpassy & Mosonyi, 1950Jansson & Zech, 1987Jansson & Zech, 1987 studied before an increase in its consumption can be recommended (Bradfield & Bjeldanes, 1991). Other examples of mutagenic, clastogenic, carcinogenic and cocarcinogenic effects of dietary constituents previously referred to are given in Table 1.…”

Section: A New Class Of Nutrients?mentioning

confidence: 99%