Neoplastic Heart Disease - The Muenster Experience With 108 Patients

Hoffmeier, A.; Schmid, Christopher H.; Deiters, S.; Drees, G.; Rothenburger, Markus; Tjan, T. D. T.; Schmidt, C; Löher, Andreas; Maintz, David; Spieker, Tilmann; Mesters, Rolf M.; Scheld, H. H.

doi:10.1055/s-2004-830389

Cited by 35 publications

(24 citation statements)

References 25 publications

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“…The mean age of patients diagnosed with PMCTs ranged from 35.8 to 68 years of age, and 52.1% of patients were female, according to the available data. For purposes of comparing studies from different periods, we used the median year of each of the following periods when the studies were performed: before 1975 in three data sets [17–19]; between 1975 and 1980 in five data sets [2, 20–23]; between 1981 and 1985 in four data sets [4, 24–26]; between 1986 and 1990 in five data sets [5, 27–30]; between 1991 and 1995 in four data sets [31–34]; between 1996 and 2000 in eight data sets [35–42]; between 2001 and 2005 in six data sets [43–48]; and after 2005 in 3 data sets [16, 49, 50] (Table 1). …”

Section: Resultsmentioning

confidence: 99%

Prevalence of primary cardiac tumor malignancies in retrospective studies over six decades: a systematic review and meta-analysis

Cao

Qin

et al. 2017

Oncotarget

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The incidence of patients diagnosed with primary malignant cardiac tumors (PMCTs) has increased greatly in the past few decades. Whether this rising prevalence is due to overdiagnosis or an increased malignancy rate of primary cardiac tumors (PCTs) remains unclear. Therefore, we performed a systematic review and meta-analysis of published retrospective studies to determine whether the malignancy rate has been increasing over time. Published studies containing relevant data between 1956 and 2014 were evaluated. Two authors searched for all retrospective studies that included patients diagnosed with PCT and PMCT. Two other investigators independently extracted the data, and discrepancies were resolved by consensus. A random-effects meta-analysis model and cumulative meta-analysis model were used to evaluate the pooled prevalence and trend of dynamic change in PCT malignancies. The effects of time, study period and sample size were studied using a logit-linear regression model with robust error variance and a time variable. Thirty-eight studies involving 5,586 patients were analyzed. The pooled prevalence of PMCT among the patients diagnosed with PCT was 9.9% (95% CI, 8.4% to 11.4%) (I2=70%; P< 0.001), and this prevalence has been stable since around 2003. In the regression model, the malignancy odds ratio remained stable from 1975 onward, and no time effect was observed. Our study confirms that PMCT is uncommon, and the prevalence of PCT malignancies remained stable in the past few decades. The clinically observed increase in incidence is unlikely to reflect a true population-level increase in tumorigenesis. This result strongly suggests that the observed increase in incidence of PMCT most likely reflects increased diagnostic detection over time.

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Section: Resultsmentioning

confidence: 99%

Prevalence of primary cardiac tumor malignancies in retrospective studies over six decades: a systematic review and meta-analysis

Cao

Qin

et al. 2017

Oncotarget

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“…Hoffmeier et al followed 108 patients and showed that the mean survival for a mixed benign and malignant population was about 5.5 years. The authors claimed that improved survival was achieved with radical surgical resection (Hoffmeier et al 2005 ). Bakaeen et al reported a mean survival of 9.6 months for 85 patients with malignant tumors (Bakaeen et al 2003 ).…”

Section: Stem Cells and Cancermentioning

confidence: 99%

Biomaterials for Cardiac Regeneration

Suuronen¹,

Ruel²

2015

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“…[2][3][4] Lipomas are benign nonmyxomatous neoplasms of the heart that normally cause no symptoms and their diagnosis is often accidental. [5][6][7] They represent 10% of the overall cardiac tumor masses arising from cardiac tissue and they are most frequently located in the right atrium. 8 The relationship of cardiac lipomas with stroke is not well established, probably because of the rarity of this type of tumors.…”

Section: Brief Communicationsmentioning

confidence: 99%

Anterior Thalamic Infarction as Initial Manifestation of a Right Atrial Lipoma

Erro

Ajuria

Olaz

et al. 2009

Can. J. Neurol. Sci

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Cardiac tumors are an infrequent source of embolism to the brain in young adults. Myxomas are the most common among them and they are mainly located in the left atrium.1 Cardiac lipomas are a very rare benign neoplasm of the heart usually located in the right atrium.2,3 Its etiological relationship with stroke is not well established. We describe the case of a thalamic stroke probably caused by paradoxical embolism from a right atrial lipoma through a patent foramen ovale. CASE REPORTA 46-year-old male with mild hypertension, presented with speech and behavioral alterations first noticed on awakening without a previous Valsalva manoeuvre. On admission his blood pressure was 150/90 mm Hg, with a pulse of 70 beats/min and O 2 saturation of 97%. He was apyretic and cardiac and cervical auscultation was unremarkable. On neurologic examination, a non-fluent dysphasia with word finding difficulties, right facial paresis and a left Horner's syndrome was observed. He also presented mild right hemiparesis and myoclonic-dystonic movements in lower limbs (NIHSS 7). Cervical and Transcranial Doppler (TCD) were normal. Cranial computerized tomography was normal. A cranial magnetic resonance (MR) demonstrated on diffusion sequences the presence of an acute non-hemorrhagic infarction involving the anterior area of the left thalamus ( Figure 1A). Perfusion MR sequences and cerebral magnetic angioresonance were normal. The patient was admitted to the stroke unit. Conservative treatment was initiated. No arrhythmia was registered during hospitalization. Duplex sonography excluded atherosclerotic lesions in the carotid arteries. The next day, a right to left massive shunt was found on TCD bubble study ( Figure 1B). This test was performed using agitated saline as a contrast agent. Thrombophilic screening, neoplastic markers and autoimmune assays were negative. Transthoracic and transesophageal echocardiograms (TEE) were performed showing a mobile mass of homogeneous density attached to the free wall of the right atrium ( Figure 1C). No other cardioembolic lesions such as aortic plaques or dysfunctional left ventricle were found. The mass could be optimally assessed by cardiac MR as a well defined, slightly lobulated and homogeneous lesion, strongly hyperintense on T1 sequences, with low signal intensity on Fat-suppressed sequences (T2 STIR) and without contrast enhancement after gadolinium administration ( Figure 1D), highly suggestive of a lipoma. A patent foramen ovale (PFO) without associated aneurysmal septum could also be seen on TEE. The mass and the foramen ovale were surgically removed THE CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES 379

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Neoplastic Heart Disease - The Muenster Experience With 108 Patients

Abstract: Heart tumours are rare, but usually life-threatening. Radical surgical resection is the therapy of choice and may offer excellent long-term survival, even in cases with malignant heart tumours.

Cited by 35 publications

References 25 publications

Prevalence of primary cardiac tumor malignancies in retrospective studies over six decades: a systematic review and meta-analysis

Prevalence of primary cardiac tumor malignancies in retrospective studies over six decades: a systematic review and meta-analysis

Biomaterials for Cardiac Regeneration

Anterior Thalamic Infarction as Initial Manifestation of a Right Atrial Lipoma

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