Biomaterials for Cardiac Regeneration

Suuronen, Erik J.; Ruel, Marc

doi:10.1007/978-3-319-10972-5

Cited by 7 publications

(3 citation statements)

References 722 publications

(1,005 reference statements)

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“…This seeding process maintains the maturation of in vitro iPSCderived SMCs by inducing functional contractile phenotype and promotes in vivo vascular structure formation (125)(126)(127). Furthermore, immense studies are required to face challenges related to selected cell types or combinations and electromechanical stimulation (41,42). Apart from this, new engineering technologies might allow three-dimensional (3D) bioprinting of biomaterials and even the building of 3D cardiac tissues that can be directly transplanted to the damaged area.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…The biomaterials-based approach is one of the most plausible ways to attain clinically successful cardiac therapies. Biomaterials used in cardiac repair should be biocompatible, biodegradable, enable cell integration with native tissue, decrease hostility of the local microenvironment and control the slow release of bioactive molecules (40)(41)(42). Both synthetic biomaterials like polylactic-co-glycolic acid (PLGA), polyurethane, and carbon nanotubes (CNTs) and natural biomaterials like fibrin, gelatin, alginate, collagen, and chitosan can be used alone as a carrier or serve as an artificial extracellular matrix (ECM) scaffold to repair and regenerate CVTs (42)(43)(44).…”

Section: Introductionmentioning

confidence: 99%

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2D Materials for Cardiac Tissue Repair and Regeneration

Gokce

Gürcan

Delogu

et al. 2022

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) have a massive impact on human health. Due to the limited regeneration capacity of adult heart tissue, CVDs are the leading cause of death and disability worldwide. Even though there are surgical and pharmacological treatments for CVDs, regenerative strategies are the most promising approaches and have the potential to benefit millions of people. As in any other tissue engineering approach, the repair and regeneration of damaged cardiac tissues generally involve scaffolds made up of biodegradable and biocompatible materials, cellular components such as stem cells, and growth factors. This review provides an overview of biomaterial-based tissue engineering approaches for CVDs with a specific focus on the potential of 2D materials. It is essential to consider both physicochemical and immunomodulatory properties for evaluating the applicability of 2D materials in cardiac tissue repair and regeneration. As new members of the 2D materials will be explored, they will quickly become part of cardiac tissue engineering technologies.

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Section: Future Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

2D Materials for Cardiac Tissue Repair and Regeneration

Gokce

Gürcan

Delogu

et al. 2022

Front. Cardiovasc. Med.

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“…Other essential cues for cardiac maturation are the electrical and mechanical signals, as in the native heart, the myocardium expands as blood enters each chamber, followed by an electrical signal that causes cellular contraction [25]. Several studies have shown the effects of static [9,26] or cyclic [27,28] mechanical stretch on the improvement of the functional and structural properties of tissue constructs.…”

Section: Introductionmentioning

confidence: 99%

A microphysiological system combining electrospun fibers and electrical stimulation for the maturation of highly anisotropic cardiac tissue

et al. 2021

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The creation of cardiac tissue models for preclinical testing is still a non-solved problem in drug discovery, due to the limitations related to the in vitro replication of cardiac tissue complexity. Among these limitations, the difficulty of mimicking the functional properties of the myocardium due to the immaturity of the used cells hampers the obtention of reliable results that could be translated into human patients. In vivo models are the current gold standard to test new treatments, although it is widely acknowledged that the used animals are unable to fully recapitulate human physiology, which often leads to failures during clinical trials. In the present work, we present a microfluidic platform that aims to provide a range of signaling cues to immature cardiac cells to drive them towards an adult phenotype. The device combines topographical electrospun nanofibers with electrical stimulation in a microfabricated system. We validated our platform using a co-culture of neonatal mouse cardiomyocytes and cardiac fibroblasts, showing that it allows us to control the degree of anisotropy of the cardiac tissue inside the microdevice in a cost-effective way. Moreover, a 3D computational model of the electrical field was created and validated to demonstrate that our platform is able to closely match the distribution obtained with the gold standard (planar electrode technology) using inexpensive rod-shaped biocompatible stainless-steel electrodes. The functionality of the electrical stimulation was shown to induce a higher expression of the tight junction protein Cx-43, as well as the upregulation of several key genes involved in conductive and structural cardiac properties. These results validate our platform as a powerful tool for the tissue engineering community due to its low cost, high imaging compatibility, versatility, and high-throughput configuration capabilities.

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Micropatterned fibrin scaffolds increase cardiomyocyte alignment and contractility for the fabrication of engineered myocardial tissue

English

Samolyk

Gaudette

et al. 2023

J Biomedical Materials Res

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Cardiovascular disease is the leading cause of death in the United States, which can result in blockage of a coronary artery, triggering a myocardial infarction (MI), scar tissue formation in the myocardium, and ultimately heart failure. Currently, the goldstandard solution for total heart failure is a heart transplantation. An alternative to total-organ transplantation is surgically remodeling the ventricle with the implantation of a cardiac patch. Acellular cardiac patches have previously been investigated using synthetic or decellularized native materials to improve cardiac function. However, a limitation of this strategy is that acellular cardiac patches only reshape the ventricle and do not increase cardiac contractile function. Toward the development of a cardiac patch, our laboratory previously developed a cell-populated composite fibrin scaffold and aligned microthreads to recapitulate the mechanical properties of native myocardium. In this study, we explore micropatterning the surfaces of fibrin gels to mimic anisotropic native tissue architecture and promote cellular alignment of human induced pluripotent stem cell cardiomyocytes (hiPS-CM), which is crucial for increasing scaffold contractile properties. hiPS-CMs seeded on micropatterned surfaces exhibit cellular elongation, distinct sarcomere alignment, and circumferential connexin-43 staining at 14 days of culture, which are necessary for mature contractile properties. Constructs were also subject to electrical stimulation during culture to promote increased contractile properties. After 7 days of stimulation, contractile strains of micropatterned constructs were significantly higher than unpatterned controls. These results suggest that the use of micropatterned topographic cues on fibrin scaffolds may be a promising strategy for creating engineered cardiac tissue.

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Biomaterials for Cardiac Regeneration

Cited by 7 publications

References 722 publications

2D Materials for Cardiac Tissue Repair and Regeneration

2D Materials for Cardiac Tissue Repair and Regeneration

A microphysiological system combining electrospun fibers and electrical stimulation for the maturation of highly anisotropic cardiac tissue

Micropatterned fibrin scaffolds increase cardiomyocyte alignment and contractility for the fabrication of engineered myocardial tissue

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