Neoplastic Cell Transformation by Heavy Charged Particles

Yang, T. C.; Craise, Laurie M.; Mei, Mantong; Tobias, Cornelius A.

doi:10.2307/3583525

Cited by 37 publications

(42 citation statements)

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“…Nevertheless, the difference between the abilities of carbon ion and iron ion radiation to induce anchorage-independent growth of the surviving population of the irradiated cells suggests a possible difference in the mechanism(s) by which the different HZE particles affect the carcinogenic process in the irradiated cells. Other investigators noted major differences in the RBE values for transformation induced by radiation from different heavy ions, with the RBEs varying in a LET-dependent manner up to 80-120 keV/µm (10) or 100-200 keV/µm (11). The LET of the carbon ions (13.6 kev/µm) was less than one tenth of that of the iron ions (150 kev/µm) used in this study.…”

Section: Discussionmentioning

confidence: 50%

“…In general, it is expected that for various types of ionizing radiations, including heavy ions, the RBE is likely to increase with LET for cytotoxic, mutagenic and carcinogenic effects, reaching a maximum at approximately 100 keV/µm (11,13). The findings presented for the cytotoxicity results, in which the effects of carbon ions, with a LET of 13.6 KeV/µm, are comparable to those of iron ions, with a LET of 150 KeV/µm, are noteworthy surprising given the expected relationship between RBE and LET.…”

Section: Discussionmentioning

confidence: 99%

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Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

2011

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Abstract. The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent high-mass, high atomic number (Z) and high-energy particles known as HZE particles, as well as γ-rays. The survival of the irradiated cells was determined by a clonogenic survival assay. The yield of colonies growing in soft agar was used as a surrogate endpoint biomarker for transformation in vitro. The results showed that HZE particles and γ-ray radiations are effective in increasing the yield of anchorage-independent colonies. Based on the relative biological effectiveness (RBE) values in the clonogenic survival assays, 0.3-GeV/n carbon ions and 1-GeV/n iron ions were 2.9 and 2.4 times, respectively, as effective as γ-rays at killing the irradiated HTori-3 cells. At a dose of 200 cGy, 0.3-GeV/n carbon ions and 1-GeV/n iron ions were found to be 3.5 and 7.3 times, respectively, as effective as γ-rays at inducing anchorage-independent growth. These results suggest that the carcinogenic potential of 0.3-GeV/n carbon ions, as represented by the ability to induce anchorageindependent growth, may be lower than that of 1-GeV/n iron ions.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

2011

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“…Predictions will be made for cell death (loss of reproductive capability) and neoplastic transformations of C3H10Tlj2 cells. The response parameters of Table 1 were found from the delayed plating experiments of Yang et al (1985) and Waligorski et al (1987). In Fig.…”

Section: Rbe = D(_a_)i/md(i/m-i)mentioning

confidence: 99%

Track structure model for damage to mammalian cell cultures during solar proton events

Cucinotta

Wilson

Townsend

et al. 1992

International Journal of Radiation Applications and Instrumenta

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Abstract-Solar proton events (SPEs) occur infrequently and unpredictably, thus representing a potential hazard to interplanetary space missions. Biological damage from SPEs will be produced principally through secondary electron production in tissue, including important contributions due to delta rays from nuclear reaction products. We review methods for estimating the biological effectiveness of SPEs using a high energy proton model and the parametric cellular track model. Results of the model are presented for several of the historically largest flares using typical levels and body shielding.

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“…Many researchers have reported that the LETrelative biological effectiveness (RBE) curves for different biological endpoints, such as cell killing, mutation induction and in vitro cell transformation are different (Skarsgard et al, 1967;Yang et al, 1985;Tsuboi et al, 1992;Chen et al, 1994;Suzuki et al, 2000;Kiefer et al, 2001;Hamada et al, 2006). It is also known that the peak positions of the LET-RBE curves appear at the LET ranging from 100 to 200 keV/µm, and is shifted to higher LET regions with heavier atomic number ion species even if the LET values are similar (Kraft et al, 1987;Belli et al, 1989;Folkard et al, 1996;Suzuki et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Difference in Biological Effectiveness Due to The Endpoints and Radiation Quality

Tsuruoka¹

2011

Biol. Sci. Space

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This paper introduces the effects of radiation quality with different ion species and various linear energy transfer on variable cell killing, remaining or initially measured breaks of G 0 /G 1 -prematurely condensed chromosome, mutation induction and deletion spectra in normal human fibroblasts. These results demonstrate that the LET-dependent structure is reflected in biological conse que nc e of the re pair process. Also, we indicate the possibility that the biological effects for different ion species are seen in not only a quantitative difference but also in a qualitative difference, in term of mutation induction. However, the importance of the biological effects caused by primary ions is still unclear in our irradiation systems, due to the use of polymethyl methacrylate absorbers of different thicknesses to change the energies of the ions. When considering the influence of galactic cosmic rays consists of high energy protons and heavy ions, it is important to further clarify the relationship between the different types of radiation and the effects.

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Neoplastic Cell Transformation by Heavy Charged Particles

Cited by 37 publications

References 0 publications

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitr

Track structure model for damage to mammalian cell cultures during solar proton events

Difference in Biological Effectiveness Due to The Endpoints and Radiation Quality

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