Neoplastic and nonneoplastic lesions in aging F344 rats

Goodman, Dawn G.; Ward, Jerrold M.; Squire, Robert A.; Chu, Kenneth C.; Linhart, M.S.

doi:10.1016/0041-008x(79)90029-2

Cited by 439 publications

(102 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The age-related increase in AHF incidence and the preponderance of eosinophilic foci in male and of basophilic foci in female SD rats is also consistent with findings for the F-344 rat (3) A striking point of difference, as noted elsewhere (10), is the greater incidence of F-344 rats with AHF, which reaches 100% by 20 mo of age (3). Our data, obtained by similar sampling methods, indicate that the incidence of SD rats with AHF does not reach 50% by this age and only approaches 75% by 2 yr of age.…”

Section: Incidence Of Ahf'supporting

confidence: 74%

“…Percentage incidences of rats with AHF are shown in (3). The size of these foci and the displacement of surrounding parenchyma initially presented us with a diagnostic challenge in differentiation from hepatocellular adenoma.…”

Section: Incidence Of Ahf'mentioning

confidence: 99%

“…Knowledge of AHF in the rat derives largely from experience with the Fischer-344 (F-344) strain, for which substantial information has been reported on spontaneously occurring AHF, including not only their morphologic characterization and incidence (3,4,10,13) but also data obtained from systematic stereologic evaluation (3). The Sprague-Dawley (SD) rat is widely used in carcinogenicity studies, yet published information on AHF in this stock is sparse compared to that on the F-344 strain.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Morphology and Incidence of Hepatic Foci of Cellular Alteration in Sprague-Dawley Rats

Newsholme

Fish

1994

Toxicol Pathol

View full text Add to dashboard Cite

Morphology and incidence of altered hepatocellular foci (AHF) were evaluated in standard H&E-stained liver sections from 3 groups of control Sprague-Dawley (SD) rats (initially 70/sex/group) used in 2 2-yr carcinogenicity studies. All AHF observed could be classified as basophilic, eosinophilic, clear, vacuolated, or mixed types using criteria applied previously to the Fischer-344 (F-344) rat. Some eosinophilic foci were large and posed a diagnostic challenge in differentiation from hepatocellular adenoma. Rats were arbitrarily divided into 3 classes by age at death: 14-17, 18-23, and 24-26 mo. As reported for F-344 rats, the incidence of SD rats with AHF increased with age, and males with eosinophilic foci predominated over males with basophilic foci whereas the opposite held true for females. Mean incidence of rats with AHF at 18-23 mo was 28 and 38% for males and females, respectively, and at 24-26 months was 68 and 71%, respectively. These data indicate a strikingly lower incidence of spontaneous AHF in SD rats than that reported for F-344 rats.

show abstract

Section: Incidence Of Ahf'supporting

confidence: 74%

Section: Incidence Of Ahf'mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Morphology and Incidence of Hepatic Foci of Cellular Alteration in Sprague-Dawley Rats

Newsholme

Fish

1994

Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…The classification of neoplastic glandular stomach lesions was based on histological criteria. 13,14) Small-intestinal tumors formed in 48% of the rats and were fibrosarcomas. There were rats (15%) with both tumors.…”

Section: Resultsmentioning

confidence: 99%

Sequential Histopathological Changes in vivo after Suicide Gene Therapy of Gastric Cancer Induced by N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine in Rats

Okino

Onda

Matsukura

et al. 2001

Japanese Journal of Cancer Research

View full text Add to dashboard Cite

“…The largest changes appeared to occur at the youngest and oldest ages examined. Age-related differences in renal cation concentrations observed in this investigation may affect functional changes reported in the kidney during aging (Goodman et al, 1979 ;Lowenstein, 1979). The five ions were selected for analysis because we wanted to compare the changes of those ions with age to earlier studies of ours examining the heart.…”

mentioning

confidence: 99%