Neoplastic and nonneoplastic hepatic changes in lake whitefish (Coregonus clupeaformis) from the St. Lawrence River, Quebec, Canada.

Mikaelian, Igor; Lafontaine, Yves de; Menard, Chantal; Tellier, Patrice; Harshbarger, John C.; Martineau, Daniel

doi:10.1289/ehp.98106179

Cited by 20 publications

(15 citation statements)

References 38 publications

(43 reference statements)

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“…The important finding of this study is the confirmation that lake whitefish from the SLR have a high prevalence of hepatic tumors and preneoplastic hepatic lesions, as indicated in our first study [7]. The slightly (but not significantly, Fisher's exact test, p Ͼ 0.05) higher prevalence observed in the present study (42/545 ϭ 7.7%) relative to that estimated in 1995 (7/141 ϭ 4.9%) may be attributed to the higher number of large (Ͼ400 mm) fish examined.…”

Section: Tumorssupporting

confidence: 77%

“…Foci of altered hepatocytes and liver neoplasms were classified according to criteria outlined by Boorman et al [9]. Other hepatic changes were categorized and graded as previously described (Table 1) [7]. Three cholangiocarcinomas and one hepatocellular carcinoma were examined by transmission electron microscopy.…”

Section: Pathologymentioning

confidence: 99%

“…External macroscopic examination was performed on 13,331 fish belonging to 40 species, and a total of 1,721 of these fish from 18 species were necropsied in 1994 and 1995 [6]. One major finding was the presence of hepatocellular and biliary tumors in the lake whitefish (Coregonus clupeaformis) [7]. No internal tumor was found upon macroscopic examination of 1,556 sympatric fish from 17 species [6].…”

Section: Introductionmentioning

confidence: 99%

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Health of Lake Whitefish (Coregonus Clupeaformis) With Elevated Tissue Levels of Environmental Contaminants

Mikaelian¹,

Lafontaine²,

Harshbarger³

et al. 2002

Environ Toxicol Chem

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Lake whitefish (Coregonus clupeaformis) were collected in 1996 from the St. Lawrence River, Quebec, Canada. Histologic examination was performed on major organs of 497 specimens and on the liver of 48 additional individuals. Preneoplastic and neoplastic hepatic changes consisted of vacuolated cell (n = 65), clear cell (n = 17), and acidophilic (n = 16) foci of altered hepatocyte, hepatocellular carcinoma (n = 12), cholangioma (n = 5), and cholangiocarcinoma (n = 28). Six fish were intersexes (1.2%), and 11.7% of the ovaries (26/223) had ducts containing spermatogonia or more differentiated cells of the male germ cell line. Asynchronous nodular maturation of the testes was present in 8.2% of the male fish (22/267). The mean hepatic concentrations of various contaminants, including polychlorinated biphenyls (PCBs), chlorobenzenes, pesticides, and trace metals, were 6 to 8 times higher in lake whitefish than in three other fish species (Ictalurus punctatus, Catostomus commersoni, and Stizostedion vitreum) collected at the same site. Condition factor of lake whitefish from this study was lower than that previously reported 40 to 50 years ago at this site and from contemporary pristine sites in the Great Lakes, USA. The presence of liver neoplasms, gonadal lesions, and a decreased condition factor in lake whitefish from the St. Lawrence River may be etiologically related to elevated tissue concentrations of toxic chemical contaminants.

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Section: Tumorssupporting

confidence: 77%

Section: Pathologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Health of Lake Whitefish (Coregonus Clupeaformis) With Elevated Tissue Levels of Environmental Contaminants

Mikaelian¹,

Lafontaine²,

Harshbarger³

et al. 2002

Environ Toxicol Chem

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“…However, it is believed that ras activation is only one of many genetic alterations that must occur for the induction of many kinds of neoplasms [37]. Neoplasms are absent or infrequent in species of salmonid fishes (including pink salmon), with the exception of domesticated strains of rainbow trout, which are highly susceptible to aflatoxin B 1 and PAH-induced tumorigenesis [17], and feral lake whitefish (Coregonus clupeaformis) from the St. Lawrence River [38]. However, it should be remembered that the K-ras protein is critical in processing external messages to the cell, in transmitting cellular signals from the cell surface to the nucleus, in the ''cross talk'' with multiple signal transduction pathways, and, ultimately, in the regulation of cell division and differentiation [39].…”

Section: Discussionmentioning

confidence: 99%

HIGH FREQUENCY OF K-ras MUTATIONS IN PINK SALMON EMBRYOS EXPERIMENTALLY EXPOSED TO EXXON VALDEZ OIL

Roy¹,

Stabile²,

Seeb³

et al. 1999

Environ Toxicol Chem

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Abstract-Previous studies demonstrated reduced survivorship of pink salmon embryos from populations in Prince William Sound, Alaska, USA, that were exposed to Exxon Valdez-released oil compared with populations from matched nonoiled streams. Survivorship was also significantly decreased in embyros from lineages that were oiled in Prince William Sound and reared in clean water under controlled hatchery conditions compared with the descendants of nonoiled lineages. This suggests that the effect of oiling on pink salmon populations was persistent and could be transmitted intergenerationally. However, the ability of environmentally released oil to cause DNA sequence alterations in natural populations has yet to be demonstrated. We used polymerase chain reaction analysis to screen for alterations in the K-ras oncogene in DNA from pink salmon embryos that were exposed under controlled laboratory conditions to weathered Prudhoe Bay crude oil. Polymerase chain reaction and direct DNA sequence analyses were used to identify mutational hotspots within exons 1 and 2 of K-ras, and 3Ј primer mismatch analysis was used to determine the frequency of mutations in the 40 offspring of two families of pink salmon that were experimentally exposed to oiled or clean gravel. Mutations were only observed at codons 12, 13, and 61 of K-ras, sites that are frequently mutated in animal and human tumors. All mutations resulted in deduced amino acid substitutions. As expected, in all individuals exhibiting mutations, the copy number of the normal allele exceeded that of the mutated allele. The frequencies of mutations in oiled embryos at K-ras exons 1 and 2 were 68 and 41%, respectively. K-ras mutations were not observed in siblings that were exposed to clean gravel or in the parents of the two experimental matings. These results indicate that exposure of pink salmon embryos to weathered Prudhoe Bay crude oil under controlled laboratory conditions can elicit somatic cell mutations in high frequency at mutational hotspots in genes such as K-ras. However, the frequency of these events in oiled natural populations of pink salmon and other vulnerable species in Prince William Sound and the heritability of these mutations within oiled lineages have yet to be evaluated.

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“…13 Other environmental studies examining epizootics of hepatocellular and biliary carcinomas in Brown bullhead catfish (Ameiurus nebulosus), 6,7,70 lake whitefish (Coregonus clupeaformis), 61 and English sole (Pleuronectes vetulus) 54,57 and exocrine pancreatic tumors in mummichog (Fundulus heteroclitus) 18 have also shown a direct correlation between water contaminants and neoplastic transformation in various target tissues.…”

mentioning

confidence: 99%

Neoplasms of the Urinary Tract in Fish

2013

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The veterinary literature contains scattered reports of primary tumors of the urinary tract of fish, dating back to 1906. Many of the more recent reports have been described in association with the Registry of Tumors in Lower Animals, and most of the spontaneous neoplasms of the kidney and urinary bladder are single case reports. In rare instances, such as described in nephroblastomas of Japanese eels and tubular adenomas/adenocarcinomas of Oscars, there is suggestion of a genetic predisposition of certain populations to specific renal neoplasms, environmental carcinogenesis, or potentially an unknown infectious etiology acting as a promoter. Hematopoeitic neoplasms have been infrequently described as primary to the kidney of a variety of fish species, and therefore those case reports of renal lymphoma and plasmacytic leukemia are addressed within the context of this review.Keywords fish and marine animals, wildlife, urinary tract, oncologyBetween 30 000 and 40 000 species of fish have been reported in the literature and included in a variety of taxonomic classes falling under the infraphylum Gnathostomata or jawed vertebrates, which further consists of the extant class Chondrichthyes or cartilaginous fish and superclass Osteichthyes or the bony fish. 37 Within that enormous number of species, there is an extraordinary variety of structure and physiology, with species ranging in size from the smallest recorded fish (Paedocypris progenetica), measuring a mere 7.9 mm, 48 to the whale shark (Rhincodon typus), measuring up to 20 m in length. 15 It is therefore reasonable to expect that the pathology of fish encompasses an immense domain of entities and pathogeneses, representing a boundless field of potential discovery in veterinary pathology, particularly concerning spontaneous neoplastic disorders. The current paucity of information is due in large part to the environment in which the subjects live, the lack of our ability to track individuals throughout their range, and the fact that autolysis and predation affect the vast majority of samples, leaving the pathologist with a limited caseload of spontaneous neoplasms within wild populations. On the other hand, zoo and aquarium populations, private tropical and marine aquaria, and farmed fish are providing veterinary pathologists with a steady flow of novel entities and new interactions between host species and disease.The following review of neoplastic disease in the urinary system of bony and cartilaginous fishes relies heavily on the body of knowledge accumulated by the National Cancer Institute's Registry of Tumors in Lower Animals (RTLA) (Experimental Pathology Laboratories, Inc, Sterling, VA), which were donated from myriad sources as well as from the diligence of those researchers who have published their findings in the international literature. In addition, other sources were consulted as part of this review to include the Armed Forces Institute of Pathology (AFIP) archives, the Smithsonian National Zoo, department of pathology, and through the gene...

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Neoplastic and nonneoplastic hepatic changes in lake whitefish (Coregonus clupeaformis) from the St. Lawrence River, Quebec, Canada.

Cited by 20 publications

References 38 publications

Health of Lake Whitefish (Coregonus Clupeaformis) With Elevated Tissue Levels of Environmental Contaminants

Health of Lake Whitefish (Coregonus Clupeaformis) With Elevated Tissue Levels of Environmental Contaminants

HIGH FREQUENCY OF K-ras MUTATIONS IN PINK SALMON EMBRYOS EXPERIMENTALLY EXPOSED TO EXXON VALDEZ OIL

Neoplasms of the Urinary Tract in Fish

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