Neoplasms, Cysts, Hamartomas, and Keratoses

Scott, Danny W.; Miller, William H.

doi:10.1016/b978-1-4377-0920-9.00016-0

Cited by 28 publications

(101 citation statements)

References 82 publications

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“…Esta neoplasia é também a mais observada em equinos no Rio Grande do Sul, variando de 57,4% ) a 43,1% (Ramos et al 2008) dos tumores diagnosticados. O sarcoide equino está associado ao papilomavírus bovino (BPV) tipos 1 e 2 (Nasir & Campo 2008, Scott & Miller Jr 2011. Recentemente foi confirmado no Brasil a ocorrên-cia de sarcoide equino associado à infecção pelo BPV BR--UEL-4 (Anjos et al 2010), que possui grande similaridade com o BPV-2 isolado em sarcoide equino, também no Brasil (Nasir & Campo 2008).…”

Section: Discussionunclassified

Estudo retrospectivo das neoplasias em ruminantes e equídeos no semiárido do Nordeste Brasileiro

Carvalho¹,

Dantas²,

Riet-Correa³

et al. 2014

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 34(3):211-216, março 2014 211 RESUMO. No Brasil, dados relacionados com a ocorrência de neoplasias em ruminantes e equinos são escassos. Objetivou-se com este trabalho determinar a frequência de neoplasias diagnosticadas em bovinos, caprinos, ovinos e equí-deos no Laboratório de Patologia Animal da Universidade Federal de Campina Grande, Patos, Paraíba, durante o perí-odo de 1983 a 2010 e analisar os fatores de risco, mediante o teste de qui-quadrado, considerando como variáveis, espécie, raça, sexo e idade. Durante o período foram registrados 177 (5,6%) tumores de um total de 3.153 diagnósticos provenientes de biópsias e necropsias. Houve diferenças significantes (p<0,001) na frequência de tumores entre as diferentes espécies sendo mais acometidos os equinos (10,6%), seguidos pelos bovinos (6,8%), caprinos (3,3%) e ovinos In Brazil, data related to occurrence of tumors in livestock are scarce. The objective of this study was to determine the frequency of tumors diagnosed in equidae, cattle, sheep and goats in the Pathology Laboratory of the Federal University of Campina Grande, Patos, state of Paraíba, from 1983 to 2010, and to analyze the risk factors by the chi square test, considering variables such as species, breed, age and sex. During the period, 177 (5.6%) out of 3153 specimens from biopsies or necropsies were diagnosed as tumors. There were significant differences (p<0.001) in the frequency of tumors among different species; horses (10.6%) were more affected than cattle (6.8%), and cattle were more affected than goats (3.3%) and sheep (2.1%). Squamous cell carcinoma was most frequent tumor in cattle (58.3% of the tumors), sheep (80%) and goats (46.1%), and sarcoid (45.3%) was the most frequent in horses. Regarding the location, neoplasms were more common in the skin of horses (62.5%) and sheep (60%), in the eyes and periocular skin in cattle (36.1%), and un the female reproductive system (perineal region and vulva) of goats (34.6%). Regarding the sex of the animals, only cattle had significant prevalence (p<0.001). Regarding age only goats showed significant prevalence (p=0.015). There was no significant prevalence in any animal species in relation to race. We concluded that squamous cell carcinomas in ruminants and equine sarcoid are the most common tumors in livestock in the semiarid Brazilian Northeast, and the equidae were the most affected among the species studied.

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Section: Discussionunclassified

Estudo retrospectivo das neoplasias em ruminantes e equídeos no semiárido do Nordeste Brasileiro

Carvalho¹,

Dantas²,

Riet-Correa³

et al. 2014

Pesq. Vet. Bras.

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“…Histologically, equine CMCT are composed of large single or multiple aggregates of 54 mast cells, intermingled with variable numbers of eosinophils and, occasionally, multifocal 55 areas of collagenolysis (Scott & Miller, 2011). All these features are also observed in other 56 equine skin lesions, among which "equine eosinophilic granuloma" (EEG), a specific chronic 57 inflammatory condition characterised by focal infiltrations of macrophages intermingled with 58 abundant eosinophils and occasionally mast cells (Scott & Miller., 2011), is the most 59 prevalent.…”

Section: Introduction 45mentioning

confidence: 86%

“…All these features are also observed in other 56 equine skin lesions, among which "equine eosinophilic granuloma" (EEG), a specific chronic 57 inflammatory condition characterised by focal infiltrations of macrophages intermingled with 58 abundant eosinophils and occasionally mast cells (Scott & Miller., 2011), is the most 59 prevalent. However, CMCT are, as the name implies, the only condition that is considered as 60 a neoplastic process, although there are ongoing discussions whether some might represent a 61 reactive process.…”

Section: Introduction 45mentioning

confidence: 88%

Equine Cutaneous Mast Cell Tumours Exhibit Variable Differentiation, Proliferation Activity and KIT Expression

Ressel

Ward

Kipar

2015

Journal of Comparative Pathology

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Equine cutaneous mast cell tumours (CMCTs) are generally considered to be benign skin lesions, although recurrent and multicentric tumours have been described. For canine CMCTs, grading and prognostic approaches are well established and aberrant KIT expression as well as high proliferation indices are associated with poor outcome. However, in the case of equine CMCTs, morphological features, proliferative activity and KIT expression pattern have not been assessed or related to biological behaviour, and there is discussion as to whether CMCTs are true neoplastic processes. The present study describes 45 equine CMCTs in terms of their morphology and KIT and PCNA expression by immunohistochemistry. KIT expression was classified as membranous (I), cytoplasmic and focally stippled (II) or diffuse cytoplasmic (III). A large proportion of the tumours were multinodular or diffuse dermal infiltrates of mast cells with mild anisokaryosis, a low proliferative rate and a dominance of KIT pattern I, representing well-differentiated CMCTs. In approximately one third of the cases, the mast cells exhibited more infiltrative growth, moderate to marked anisokaryosis and a higher degree of proliferation. These were classified as poorly differentiated CMCTs and exhibited only KIT patterns II and III. These findings indicate that there is a subgroup of poorly differentiated equine CMCTs, in which there is an association between aberrant KIT expression, high proliferative rate and potential aggressive behaviour, all features that confirm at least the poorly differentiated CMCT as a true neoplastic processes.

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“…1,4,16,24,27 In horses, S100 protein is the marker consistently expressed in melanocytic neoplasms. 22 Tyrosinase expression has been detected by immunohistochemistry or molecular methods in equine melanomas, 11,23 but benign equine melanocytic tumors apparently do not express tyrosinase. 23 Monoclonal antibody HMB-45, which recognizes the melanocytic differentiation antigen gp 100, is also expressed in equine malignant melanomas.…”

mentioning

confidence: 99%

“…22 Several clinical forms of equine melanocytic tumors have been described: melanocytic nevus, dermal melanoma, dermal melanomatosis, and anaplastic malignant melanoma. 26 Despite the benign phenotype of many melanocytic proliferations, most equine melanocytic neoplasms, other than melanocytic nevus, should be considered at least potentially malignant.…”

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confidence: 99%

Immunohistochemical Expression of Melanocytic Antigen PNL2, Melan A, S100, and PGP 9.5 in Equine Melanocytic Neoplasms

et al. 2013

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The immunoreactivity of PNL2, Melan A, and protein gene product (PGP) 9.5 was compared with that of S100 protein in 50 formalinfixed, paraffin-embedded equine melanocytic neoplasms. PNL2, PGP 9.5, and S100 protein were detected in all 50 neoplasms; none expressed Melan A. PNL2 was not expressed in 62 nonmelanocytic tumors (equine sarcoids, schwannomas, carcinomas, sarcomas, endocrine tumors, sex-cord stromal tumors, germ cell tumors, and leukocytic tumors) or in normal tissues other than epidermis. In summary, antibody PNL2 is a sensitive marker of equine melanocytic neoplasms and is more specific than S100 protein or PGP 9.5. In contrast, the monoclonal antibody to Melan A did not react with any of the equine melanomas.

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Neoplasms, Cysts, Hamartomas, and Keratoses

Cited by 28 publications

References 82 publications

Estudo retrospectivo das neoplasias em ruminantes e equídeos no semiárido do Nordeste Brasileiro

Estudo retrospectivo das neoplasias em ruminantes e equídeos no semiárido do Nordeste Brasileiro

Equine Cutaneous Mast Cell Tumours Exhibit Variable Differentiation, Proliferation Activity and KIT Expression

Immunohistochemical Expression of Melanocytic Antigen PNL2, Melan A, S100, and PGP 9.5 in Equine Melanocytic Neoplasms

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