Neonates with coronavirus disease 2019 acquired from infected mothers: the incompatibility of maternal intensity and infant lung involvement: two case reports

Abstract

Background The outbreak of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health emergency by the World Health Organization on January 30, 2020. The results of recent studies have suggested that neonates may present symptoms of COVID-19. Although the presentation of the disease in neonates is known to vary, only a limited number of studies have investigated newborns infected with COVID-19. Case presentation This study presents two Asian cases of newborns with COVID-19. Maternal–fetal or postnatal transmission was suggested based on the simultaneity of maternal infection. Chest radiography in one of the neonates showed severe lung involvement. Despite support and resuscitation attempts, the poor clinical condition of the neonate led to his death. However, the two mothers and one of the neonates were discharged from the hospital in good general condition. Conclusion The neonates had worse clinical conditions than the mothers, and the intensity of pneumonia and level of lung involvement in the newborns were not associated with the stage and severity of the disease in the mothers with COVID-19.

Severe pulmonary hemorrhage in a 3-week old neonate with COVID-19 infection: A case report

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third virus of the twenty-first century to become a global concern. 2 Qatar, a country that embraces a population of variable nationalities and ethnicities, was hit by the third wave of COVID-19 infection in early January 2022, the time at which the patient and her family in this case report acquired COVID-19 infection. Though the patient was not tested for the exact variant of COVID-19 virus, we know that 95% of the tested cases at that period were of Omicron variant.…”

Severe pulmonary hemorrhage in a 3‐week‐old neonate with COVID‐19 infection: A case report

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the third virus of the twenty‐first century to become a global concern 2 . Qatar, a country that embraces a population of variable nationalities and ethnicities, was hit by the third wave of COVID‐19 infection in early January 2022, the time at which the patient and her family in this case report acquired COVID‐19 infection.…”

“…Newborns can also be infected with SARS‐CoV‐2 due to the immaturity of their immune systems; however, uncommon presentations have been associated with this age group 2 . In the few published cases of COVID‐19 in neonates, the presentation was that of late neonatal sepsis; interestingly, the lung involvement was not as common as in the older children and adults 7 …”

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

“…18 Another study reported two neonatal cases infected with COVID-19 who were born to mothers infected at the end of the third trimester of pregnancy. 19 In an Italian series comprising 22 women affected by COVID-19, Patanè et al identified two cases of mothers with a positive polymerase chain reaction (PCR) test who also were positive for SARS-CoV-2 in the placenta and in their neonates. 6 Another study showed the potential for intrauterine transmission of SARS-CoV-2 infection.…”

“…Though the first case was observed in China in December 2019, coronavirus disease 2019 (COVID- 19) was first identified in Turkey on the 9th of March 2020, later than many countries. 1 The rapid national and international spread of COVID-19 resulted in 240,260,449 cases with 4,890,424 deaths globally by October 19th 2021.…”