Percutaneous treatment of thrombotic occlusions with RT, followed by definitive treatment of the underlying stenosis, is a promising therapeutic option for patients with limb-threatening ischemia.

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Percutaneous treatment of thrombotic occlusions with RT, followed by definitive treatment of the underlying stenosis, is a promising therapeutic option for patients with limb-threatening ischemia.

Background. Gene-expression profiles have been reported to distinguish between patients with and without active tuberculosis (TB), but no prior study has been conducted in the context of TB screening. Methods. We included all the patients (n = 40) with culture-confirmed TB and time-matched controls (n = 80) enrolled between July 2013 and April 2015 in a TB screening study among people living with human immunodeficiency virus (PLHIV) in Kampala, Uganda. We randomly split the patients into training (n = 80) and test (n = 40) datasets. We used the training dataset to derive candidate signatures that consisted of 1 to 5 differentially-expressed transcripts (P ≤ .10) and compared the performance of our candidate signatures with 4 published TB gene-expression signatures, both on the independent test dataset and in 2 external datasets. Results. We identified a novel, 5-transcript signature that met the accuracy thresholds recommended for a TB screening test. On the independent test dataset, our signature had an area under the curve (AUC) of 0.87 (95% confidence interval [CI] 0.72-0.98), with sensitivity of 94% and specificity of 75%. None of the 4 published TB signatures achieved desired accuracy thresholds. Our novel signature performed well in external datasets from both high (AUC 0.81, 95% CI 0.74-0.88) and low (0.81, 95% CI 0.77-0.85) TB burden settings. Conclusions. We identified the first gene-expression signature for TB screening. Our signature has the potential to be translated into a point-of-care test to facilitate systematic TB screening among PLHIV and other high-risk populations.

Background: Drooling related to bulbar weakness and dysfunction is a common concern in patients with neuromuscular disease. While there are numerous medications to manage sialorrhea, they are often limited by side effects and lack of efficacy. Botulinum toxin has shown to benefit ALS patients in a few studies, but there is scant data on the benefit in other neuromuscular conditions. Objective: To assess the effectiveness of Botulinum toxin in reducing sialorrhea in patients with various neuromuscular disease. Design/Methods: 25 patients (19M, 6F; 54.36 ± 17.09 yr) with documented neuromuscular illness and concern for drooling was followed for 6 weeks after Botulinum toxin injection. These patients had one of the following diagnoses: Duchenne muscular dystrophy (3), myotonic dystrophy (3), oculopharyngeal muscular dystrophy (1), inclusion body myositis (2), primary lateral sclerosis (1), amyotrophic lateral sclerosis (9), spinal muscular atrophy type 2 and 3 (2), spinal-bulbar muscular atrophy (2), and Becker's muscular dystrophy (2). A subjective drooling scale (1: markedly worse, 5: markedly better) and drooling thickness score (0=normal, 100=thick) was calculated on these patients prior to the injection and 4 and 6 weeks after the injection. Botulinum toxin 20-30 units were injected into bilateral parotid gland (70% of the dose) and submandibular gland (30% of the dose). Results: The drooling thickness score at before the injection was 75.2 ± 10.46. At 4 and 6 weeks, average scores reduced to 47.2 ± 6.14 and 18.8 ± 5.26, respectively (p < 0.05). The average pre injection perception about drooling was 3.0 (p < 0.05). The average change in perception was +0.84 and +1.28 at 4 and 6 weeks, respectively, (p < 0.05) implying significant improvement. There were no reported adverse effects. Conclusion: This study provides preliminary evidence for the use of botulinum toxin for refractory sialorrhea for a variety of neuromuscular conditions.

?? 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Labib A, and Alinier G. 'Can simulation improve ECMO care?', Qatar Medical Journal, 4th Annual ELSO-SWAC Conference Proceedings 2017:7 http://dx.doi.org/10.5339/qmj.2017.swacelso.7???Bringing ECMO simulation to life???: The main theme of the 4th Annual Conference of the Extracorporeal Life Support Organisation ??? South and West Asia Chapter (ELSO-SWAC), ???Bringing ECMO Simulation to Life???, is meant to emphasise the growing role of simulation in healthcare and medical education at large and in the highly specialised and complex field of extracorporeal life support (ECLS), and in particular for extracorporeal membrane oxygenation (ECMO). Application of ECMO simulation to improve team response to ECMO emergencies was first described in 2006. 1 In the last decade, several authors have described the development, utility, and advantages of simulation-based training for ECMO. In this editorial, we will discuss the role of and evidence supporting the use of simulation-based education in ECMO. ECMO is a complex intervention: The first point to consider when it comes to ECMO is the complexity, time critical, and inter-disciplinary nature of the intervention. Typically, ECMO is considered for the most sick and physiologically deranged patient, sometimes as a last resort rescue measure. Time pressure, the patient critical condition, the potential rapid deterioration, and the uncertainty interact within the critical care environment to make decision-making, planning, and execution quite challenging for the less experienced members of the clinical team. This relates to the domains of team and crisis resource management in which there is a complex interplay of human and environmental factors involved. 2 Appropriate training programmes of the required technical and non-technical skills for ECMO are lacking. 3,4 In addition, ECMO is relatively new to many centres and/or countries, and this novelty brings with it a general lack of experience regarding such therapy and the fear of the unknown. Simulation can help relieve staff anxiety and introduce ECMO in a safe, less intimidating learning environment. 3,4 Ideally, all aspects of ECMO patient care can be progressively introduced to the staff being trained through the use of various simulation modalities to promote better understanding and deep learning regarding the initiation of an ECMO run and ongoing ECMO patient care. Read More: http://www.qscience.com/doi/abs/10.5339/qmj.2017.swacelso.

Alzheimer's disease (AD) deteriorates executive, linguistic, and functional capacity and is rapidly becoming more preva lent. In particular, AD leads to an inability to follow sim ple dialogues. In this paper, we annotate two databases of dyad conversations, that include individuals with AD, with trouble indicating behaviors (TIBs). We then extract lexi cal/syntactic and acoustic features from all utterances and identify those that are most indicative of TIB (which include speech rate and utterance likelihoods in a standard language model) and classify utterances as having TIB or not with up to 79.5% accuracy. This will allow us to build automated dialogue systems and assessment tools that are sensitive to confusion in people with AD.