Neonatal small left colon syndrome in the offspring of diabetic mothers—an analysis of 105 children

Ellis, Helen; Kumar, Rajendra; Kostyrka, Ben

doi:10.1016/j.jpedsurg.2009.07.054

Cited by 40 publications

(19 citation statements)

References 13 publications

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“…IDMs also may exhibit the neonatal small left colon syndrome [99], which can present much like Hirschsprung disease (rectal/colonic aganglionosis). Neonatal small left colon syndrome is the most common cause of intestinal obstruction in IDMs.…”

Section: Small Left Colon Syndromementioning

confidence: 99%

Care of the Infant of the Diabetic Mother

Hay

2011

Curr Diab Rep

105

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Gestational diabetes mellitus (GDM) from all causes of diabetes is the most common medical complication of pregnancy and is increasing in incidence, particularly as type 2 diabetes continues to increase worldwide. Despite advances in perinatal care, infants of diabetic mothers (IDMs) remain at risk for a multitude of physiologic, metabolic, and congenital complications such as preterm birth, macrosomia, asphyxia, respiratory distress, hypoglycemia, hypocalcemia, hyperbilirubinemia, polycythemia and hyperviscosity, hypertrophic cardiomyopathy, and congenital anomalies, particularly of the central nervous system. Overt type 1 diabetes around conception produces marked risk of embryopathy (neural tube defects, cardiac defects, caudal regression syndrome), whereas later in gestation, severe and unstable type 1 maternal diabetes carries a higher risk of intrauterine growth restriction, asphyxia, and fetal death. IDMs born to mothers with type 2 diabetes are more commonly obese (macrosomic) with milder conditions of the common problems found in IDMs. IDMs from all causes of GDM also are predisposed to later-life risk of obesity, diabetes, and cardiovascular disease. Care of the IDM neonate needs to focus on ensuring adequate cardiorespiratory adaptation at birth, possible birth injuries, maintenance of normal glucose metabolism, and close observation for polycythemia, hyperbilirubinemia, and feeding intolerance.

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Section: Small Left Colon Syndromementioning

confidence: 99%

Care of the Infant of the Diabetic Mother

Hay

2011

Curr Diab Rep

105

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“…Le SMCG est considéré comme une cause rare d'occlusion intestinale néonatale [1]. Le diabète maternel a été rapporté dans 40 à 50 % de l'ensemble des cas publiés de SMCG.…”

Section: Discussionunclassified

“…Le diabète maternel a été rapporté dans 40 à 50 % de l'ensemble des cas publiés de SMCG. Le SMCG paraît être la première cause d'occlusion intestinale chez les nouveau-nés de mères diabétiques [1]. Le tableau clinique comporte un retard d'émission de méco-nium, un ballonnement abdominal, des vomissements et rarement des perforations [2][3][4].…”

Section: Discussionunclassified

Une cause rare d’occlusion intestinale néonatale

Ksia¹,

Zrig²,

Sahnoun³

et al. 2014

Feuillets de Radiologie

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“…Das Fehlbildungsmuster der diabe tischen Embryopathie ist unspezifisch (Neuralrohrdefekte, konotrunkale Herz fehler, Omphalozelen, Skelettanomalien, Fehlbildungen der Nieren und ableiten den Harnwege), die Anzahl der betroffe nen Organsysteme steigt mit den mater nen Glukosewerten [55], nur bei einigen sehr seltenen Fehlbildungen (kaudales Regressionssyndrom, "smallleftcolon" Syndrom) kann ein mütterlicher Diabe tes als charakteristisch gelten [22,29,46]. Auf die erhöhte Fehlbildungsrate geht ein wesentlicher Anteil der erhöhten perina talen Mortalität (Tod zwischen Schwan gerschaftswoche 20 bzw.…”

Section: Konsensuspapiere Diabetische Embryopathieunclassified

“…Auf die erhöhte Fehlbildungsrate geht ein wesentlicher Anteil der erhöhten perina talen Mortalität (Tod zwischen Schwan gerschaftswoche 20 bzw. 22 und Lebens tag 7) von Kindern diabetischer Mütter zurück [63,67].…”

Section: Konsensuspapiere Diabetische Embryopathieunclassified