Neonatal septicaemia in Calabar, Nigeria

Anah, MU; Udo, JJ; Ochigbo, S O; Abia-Bassey, Lydia N.

doi:10.1258/td.2006.006037

Cited by 42 publications

(62 citation statements)

References 3 publications

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“…This report is similar to that by Anah in Calabar also South Eastern Nigeria, who reported Gram-positive as the predominant organism Staphylococcus aureus 53% while for Gram-negative E.coli accounts for 47% [38]. Report by Ako-nai in Ile-Ife reported Gram-positive Streptococcus spp as predominant in (45.3%) while Klebsiella spp in (54.7%) [38]. Ambe and colleagues in Maiduguri reported Staphylococcus aureus as the predominant organism (46.2%) and Klebsiella spp the predominant Gramnegative organism (24.8%) [31].…”

Section: Epidemiology Of Neonatal Septicaemiasupporting

confidence: 90%

Section: Epidemiology Of Neonatal Septicaemiasupporting

confidence: 85%

“…However this results were much higher than that by Ako-nai from Ile-Ife who reported the incidence of 5.5/1000 live births [37] The reason for the differences may partly be explained by the worsening economic situation of the country in the recent time so much that families live in poor housing condition and have difficulty in accessing good healthcare services. Anah et al (2006) from Calabar, South-South Nigeria reported an incidence of 54.9/1000 live birth [38]. This report is much higher than the earlier report from the same centre by AntiaObong (1990) who reported an incidence of 19.3/1000 live births [39], The reasons given for this higher incidence were shortage of public water supply in Calabar metropolis and its environment, mothers presenting to their Hospital "only" when labour is complicated and generally poor utilization of available health care facilities among other reasons.…”

Section: Epidemiology Of Neonatal Septicaemiamentioning

confidence: 99%

“…The gold standard of diagnosis of septicaemia is a positive blood culture in the presence of clinical features and/or risk factors of septicaemia [3,14,38]. Blood samples collected for cultures must be adequate, usually 1-3 ml for both aerobic and anaerobic cultures, depending on the type of culture media [19].…”

Section: Blood Culturementioning

confidence: 99%

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Neonatal Septicaemia in Poor Resource Settings

Pius¹,

Bello²

2017

Pediatric Infect Dis

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Section: Epidemiology Of Neonatal Septicaemiasupporting

confidence: 90%

Section: Epidemiology Of Neonatal Septicaemiasupporting

confidence: 85%

Section: Epidemiology Of Neonatal Septicaemiamentioning

confidence: 99%

Section: Blood Culturementioning

confidence: 99%

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Neonatal Septicaemia in Poor Resource Settings

Pius¹,

Bello²

2017

Pediatric Infect Dis

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“…The incidence of neonatal septicemia in developed countries such as Europe and North America is low and ranges between 0.95/1000 live births and 3/1000 live birth [4] [6]. However, in developing countries of Africa and Asia, the incidence is still alarmingly high, ranges from as high as 54.9/1000 live births in Nigeria to around 30/1000 live births in countries like India [7] [8].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Haematological Indices of Neonatal Septicaemia in Poor Resource Setting

Pius¹,

Bello²,

Galadima³

et al. 2016

OJPed

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Background: The burden of neonatal septicaemia has remained high worldwide and even more severe in the developing countries like ours. Clinical manifestation is variable and non-specific thereby resulting in delay in diagnosis. Blood culture which is the gold standard for diagnosis of neonatal septicaemia (NNS) has many drawbacks due to long waiting time for culture process, low yield, improper inoculation adding to the problem of late diagnosis. Haematological parameters have been utilized in rapid and early diagnosis of NNS and prompt treatment thus circumventing problems associated with drawbacks in blood culture. Objective: The study was to identify the common clinical features of neonatal septicaemia and haematological indices that were commonly utilized in rapid diagnosis of NNS, and also to determine their sensitivity, specificity, positive predictive and negative predictive value. Materials and Methods: The study was prospective and neonates that had clinical features suggestive of neonatal septicaemia were enrolled consecutively into the study. The patients were appropriately investigated including blood cultures, CSF cultures and urine among others, also blood sample for packed cell volume (PCV), total white cell count (TWBC), absolute neutrophil count (ANC), absolute platelet count (APC). Immature to mature neutrophil ratio (I/MNR), immature to total neutrophil ratio (I/TNR) and micro-ESR (erythrocyte sedimentation rate) was also done and analyzed. Results: The common clinical symptoms were fever 39.5%, poor feeding 33.6%, excessive cry 38.7%, difficulty in breathing 50.0%, yellowish skin 26.9%, while the common physical signs were hyper/hypothermia 41.1%, tachypnoea 41.2%, septic umbilical stump 64.0%, hepatomegally 37.3% and convulsions 42.0%. Blood culture yield was positive in 41.82% and mortality was as high as 28.00%, the incidence of NNS was 5.9/1000 live births. The haematological parameters as marker of NNS PCV, TWBC, ANC, APC, I/MNR, I/TNR * Corresponding author. S. Pius et al. 61and micro-ESR individually were statistically significant (P < 0.05), also their individual sensitivity, specificity, positive and negative predictive values were highly associated with neonatal septicaemia. However, when they were tested in combinations these markers of neonatal septicaemia had low sensitivity, specificity and their predictive values were weak in excluding NNS. Conclusions: The need for early and rapid diagnosis of NNS is pertinent, culturing of the appropriate specimens remains the only way to identify the aetiological organisms, but is associated with delay. Haematological indices are excellent markers of NNS and analysis is rapid and can easily be done in our laboratory settings, and when utilized efficiently, it would circumvent the delay associated with blood culture for long waiting period for the result, thereby reducing morbidity and mortality.

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Chromobacterium violaceum and its important metabolites — review

2010

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C. violaceum appeared as important bacterium in different applications and mainly these aspects are related to the production of violacein. This review discusses the last reports on biosynthetic pathways, production, genetic aspects, biological activities, pathological effects, antipathogenic screening through quorum sensing, environmental effects and the products of C. violaceum with industrial interest. An important discussion is on biological applications in medicine and as industrial products such as textile and in cosmetics.

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Neonatal septicaemia in Calabar, Nigeria

Cited by 42 publications

References 3 publications

Neonatal Septicaemia in Poor Resource Settings

Neonatal Septicaemia in Poor Resource Settings

Clinical Features and Haematological Indices of Neonatal Septicaemia in Poor Resource Setting

Chromobacterium violaceum and its important metabolites — review

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