Neonatal sepsis in Jamaican neonates

Bell, Y.; Barton, Michelle; Thame, M; Nicholson, Alison; Trotman, H

doi:10.1179/146532805x72449

Cited by 17 publications

(16 citation statements)

References 8 publications

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“…The Americas Martin et al 41 Vaciloto et al 42 Bell et al 43 Trotman et al 44 Castrodale et al 45 Chen et al 46 Hyde et al 47 Mayor-Lynn et al 48 Phares et al 49 Puopolo et al 50 CDC et al 51 Stoll et al 52 CDC et al 53 Brooks et al 54 Cordero et al 55 Jordan et al 56 Subtotal (I 2 =97·4%, p=0·000)…”

Section: Data Extractionmentioning

confidence: 99%

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Edmond¹,

Kortsalioudaki²,

Scott³

et al. 2012

The Lancet

524

457

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SummaryBackground Despite widespread use of intrapartum antibiotic prophylaxis, group B streptococcus remains a leading cause of morbidity and mortality in infants in Europe, the Americas, and Australia. However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates.

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Section: Data Extractionmentioning

confidence: 99%

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Edmond¹,

Kortsalioudaki²,

Scott³

et al. 2012

The Lancet

524

457

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“…62 In some case series Klebsiella is recognized as the most common gram-negative agent associated with LOS, ranging from 20–31% of cases. 63,64 Infections due to Pseudomonas have been associated with the highest mortality. 65 Citrobacter is uniquely associated with brain abscesses, but dissemination can occur to other organs.…”

Section: Late Onset Sepsis (Los)mentioning

confidence: 99%

Neonatal Infectious Diseases

Camacho-González

Spearman

Stoll

2013

Pediatric Clinics of North America

362

143

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Synopsis Neonatal sepsis remains a feared cause of morbidity and mortality in the neonatal period. Maternal, neonatal and environmental factors are associated with risk of infection, and a combination of prevention strategies, judicious neonatal evaluation and early initiation of therapy are required to prevent adverse outcomes. The following chapter reviews recent trends in epidemiology, and provides an update on risk factors, diagnostic methods and management of neonatal sepsis.

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“…This pattern of sepsis may be similar to that of a developed country since the majority of paediatric sepsis cases occur in neonates and decrease as the children age. In a retrospective review by Bell et al, the incidence of neonatal sepsis at the UHWI was 6.7 per 1000 live births (13). This study cannot be compared with the current study because a restricted definition of culture-proven bacterial sepsis was used in the former, as compared to the latter where the ICD-10 formed the basis of the inclusion criteria (12).…”

Section: Discussionmentioning

confidence: 69%

Burden of Paediatric Sepsis in a Tertiary Centre from a Developing Country

Olugbuyi¹,

Swaby²,

Roberts³

et al. 2017

West Indian Med J

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Background: Sepsis causes significant paediatric morbidity and mortality in developing countries. This paper describes the outcome of paediatric sepsis in the University Hospital of the West Indies (UHWI), Jamaica, using administrative data from hospital records from 2010 to 2014. Objective: To provide baseline data on the burden and outcome of paediatric sepsis in a tertiary institution in Jamaica between 2010 and 2014 so as to embark on initiatives to build capacity to provide care in order to decrease the burden and improve the outcomes from sepsis in children. Methods: Data were abstracted from electronic discharge summaries of children hospitalized at the UHWI, a tertiary centre that accepts referrals for newborns and children with complex disorders. The medical records of children aged 0-16 years who were hospitalized with a diagnosis of sepsis, septicaemia and neonatal sepsis were reviewed, using the World Health Organization's International Classification of Diseases, 10 th Revision (ICD-10). Demographic and outcome data were extracted. Results: Among 7011 children aged 0-16 years who were admitted, sepsis accounted for 801 hospitalizations in 782 children with a male to female ratio of 1.27 to 1. Neonates comprised 86% (n = 691), of which 36.2% (n = 250) were preterm. The median duration of hospitalization was 10 days (range: 0-366 days; interquartile range: 7-19 days). The sepsis-attributable mortality rate was 10.1% (n = 70) in neonates and was higher in preterm versus term neonates (18.4%, n = 46/250 versus 6.0%, n = 26/434, respectively). The annual crude mortality rate for paediatric sepsis was 9-11% (12 per 1000 paediatric hospitalizations). Conclusion: Sepsis accounted for a high number of admissions and consumed significant resources as evidenced by the long duration of hospitalization. The mortality rate for paediatric sepsis was high, especially in newborns. Targeted interventions are needed to reduce the sepsis-attributable burden and improve outcomes established by the Global Sepsis Alliance and United Nations' Sustainable Development Goals.

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Neonatal sepsis in Jamaican neonates

Cited by 17 publications

References 8 publications

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Neonatal Infectious Diseases

Burden of Paediatric Sepsis in a Tertiary Centre from a Developing Country

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