Neonatal sepsis in a tertiary care hospital in Delhi, India: study of microbial profile and antimicrobial susceptibility pattern

Gupta, Sapna; Singh, Varun; Singhal, Sanjay; Chowdhary, Priti

doi:10.18203/2349-3291.ijcp20190036

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 Hospital acquired sepsis is the most common infection in NICUs. [8][9][10] Up to 30% increased chances of infection have been reported in ICU admitted patients as compared to general population. 4 Nosocomial infection may be caused by a bacterial, viral or fungal organism.…”

Section: Introductionmentioning

confidence: 99%

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Naz

Saleem

Khurshid³

et al. 2022

TPMJ

View full text Add to dashboard Cite

Objective: To find out common organism causing nosocomial sepsis in neonatal intensive care unit (NICU) and their sensitivity to frequently used antibiotics. Study Design: Cross Sectional study. Setting: NICU Pediatric Department of Nishtar Hospital Multan. Period: May 2018 to April 2019. Material & Methods: A total of 111 neonates of either gender admitted with blood culture proven sepsis were included in the study. For culture, blood samples were taken, ensuring standard antiseptic measures, either from a peripheral vein or an artery. Any growth of bacteria after incubation of 24 to 48 hours with only BACTEC and VITEK-2 technique were included, and their drug sensitivity recorded. Demographic data along with causative microorganisms, sensitivity and resistant patterns to frequently used drugs were recorded. Results: Out of 111 patients, 61 (55%) were male. Early onset sepsis (EOS) was present in 37 (33%) patients and 74 (66%) had late onset sepsis (LOS). Serratia species 33 (29.7%) and Staphylococcus epidermidis 31 (27.9%) were the commonest causative bacteria responsible for neonatal sepsis. Commonly involved microorganisms were highly resistant to frequently used antibiotics like ampicillin /amoxicillin, cefixime, ceftazidime. Conclusion: Nosocomial sepsis is a major health issue in NICU while and resistance of pathogens to commonly used antibiotics is alarming.

show abstract

Section: Introductionmentioning

confidence: 99%

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Naz

Saleem

Khurshid³

et al. 2022

TPMJ

View full text Add to dashboard Cite

show abstract

Early-onset neonatal sepsis and antibiotic use in Indonesia: a descriptive, cross-sectional study

et al. 2022

View full text Add to dashboard Cite

Background Early diagnosis and prompt antibiotic treatment are crucial to reducing morbidity and mortality of early-onset sepsis (EOS) in neonates. However, this strategy remains challenging due to non-specific clinical findings and limited facilities. Inappropriate antibiotics use is associated with ineffective therapy and adverse outcomes. This study aims to determine the characteristics of EOS and use of antibiotics in the neonatal-intensive care units (NICUs) in Indonesia, informing efforts to drive improvements in the prevention, diagnosis, and treatment of EOS. Methods A descriptive study was conducted based on pre-intervention data of the South East Asia-Using Research for Change in Hospital-acquired Infection in Neonates project. Our study population consisted of neonates admitted within 72 h of life to the three participating NICUs. Neonates who presented with three or more clinical signs or laboratory results consistent with sepsis and who received antibiotics for 5 consecutive days were considered to have EOS. Culture-proven EOS was defined as positive blood or cerebrospinal fluid culture. Type and duration of antibiotics used were also documented. Results Of 2,509 neonates, 242 cases were suspected of having EOS (9.6%) with culture-proven sepsis in 83 cases (5.0% of neonatal admissions in hospitals with culture facilities). The causative organisms were mostly gram-negative bacteria (85/94; 90.4%). Ampicillin / amoxicillin and amikacin were the most frequently prescribed antibiotics in hospitals with culture facilities, while a third-generation cephalosporin was mostly administered in hospital without culture facilities. The median durations of antibiotic therapy were 19 and 9 days in culture-proven and culture-negative EOS groups, respectively. Conclusions The overall incidence of EOS and culture-proven EOS was high in Indonesia, with diverse and prolonged use of antibiotics. Prospective antibiotic surveillance and stewardship interventions are required.

show abstract

Neonatal sepsis in a tertiary care hospital in Delhi, India: study of microbial profile and antimicrobial susceptibility pattern

Cited by 2 publications

References 0 publications

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Neonatal nosocomial sepsis in Level-III NICU: Causative pathogens and their antimicrobial sensitivity.

Early-onset neonatal sepsis and antibiotic use in Indonesia: a descriptive, cross-sectional study

Contact Info

Product

Resources

About