Neonatal screening for congenital cytomegalovirus infection and hearing loss

Barbi, Maria; Binda, Sandro; Caroppo, Simona; Prímache, V.

doi:10.1016/j.jcv.2005.08.010

Cited by 76 publications

(56 citation statements)

References 20 publications

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“…Nevertheless, it has been reported that approximately 15% of asymptomatic children will develop some degree of hearing loss following congenital CMV infection [27]. Globally, CMV causes around 10% of congenital SNHL [28,29]. This deficit may be present at birth or develop later in childhood usually during the first year of life, with a great variability in the severity ranging from unilateral high-frequency losses to profound bilateral losses [27,30].…”

Section: Resultsmentioning

confidence: 99%

“…This deficit may be present at birth or develop later in childhood usually during the first year of life, with a great variability in the severity ranging from unilateral high-frequency losses to profound bilateral losses [27,30]. Development of new diagnostic tools such as dried blood spots (DNA detection in Guthrie cards) helps to retrospectively attribute SNHL to congenital CMV infection [20,31,32]. …”

Section: Resultsmentioning

confidence: 99%

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Management of Pregnancies with Confirmed Cytomegalovirus Fetal Infection

Benoist

Leruez‐Ville

et al. 2013

Fetal Diagn Ther

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Systematic screening for cytomegalovirus (CMV) maternal infection is not recommended in most countries. Nevertheless, primary CMV infection will occur in around 1% of women. The vertical transmission rate is estimated to be around 30-50%. Newborns with congenital CMV infection remain asymptomatic in the majority of cases and around 10% will present with a wide range of abnormalities. Fetal infection can be diagnosed by amniocentesis with amplification of the viral genome in the amniotic fluid by polymerase chain reaction. This prenatal diagnosis is mainly performed when ultrasound abnormalities are observed. The purpose of this mini-review is to describe the management options when a fetus is known to be infected.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Management of Pregnancies with Confirmed Cytomegalovirus Fetal Infection

Benoist

Leruez‐Ville

et al. 2013

Fetal Diagn Ther

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“…Moreover, effective and productive screening involves an assessment of the importance of the disease as a public health problem. Neonatal screening for hearing impairment meets all these criteria and therefore is accepted in most countries (4). Most countries choose to perform the neonatal hearing screening before discharge out of the maternity unit.…”

Section: Discussionmentioning

confidence: 99%

Detection of Perinatal Cytomegalovirus Infection and Sensorineural Hearing Loss in Belgian Infants by Measurement of Automated Auditory Brainstem Response

Verbeeck

Kerschaver²,

Beuselinck³

et al. 2008

J Clin Microbiol

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Since auditory disability causes serious problems in the development of speech and in the total development of a child, it is crucial to diagnose possible hearing impairment as soon as possible after birth. This study evaluates the neonatal hearing screening program in Flanders, Belgium. The auditory ability of 118,438 babies was tested using the automated auditory brainstem response. We selected 194 babies with indicative hearing impairment and 332 matched controls to investigate the association between the presence of human cytomegalovirus (HCMV) in urine samples and sensorineural hearing loss and to analyze the sensibility and specificity of a cell culture assay and a quantitative PCR detection method. Our results indicate that significantly more babies with confirmed hearing impairment were HCMV positive after birth. Further, based on the results of our study, babies with HCMV viral loads above 4.5 log copies/ml urine seem to be 1.4 times more likely to have confirmed hearing impairment. Our follow-up study suggests that the hearing impairment of children infected with HCMV after birth is less likely to improve than that of HCMV-negative infants. Our results confirm that the presence of HCMV before or shortly after birth influences the outcome of hearing impairment.

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“…This test has also been used to evaluate the prevalence of congenital CMV infection in children with cortical development disorders (such as pachigiria and leucodystrophy of unknown origin) (52). The same test revealed that 20-30% of all cases of infantile deafness were due to congenital CMV infection (53,54).…”

Section: (Asd) Are Neurodevelopmental Disorders Without a Definitive mentioning

confidence: 99%