Neonatal Respiratory Failure: A 12-Month Clinical Epidemiologic Study From 2004 to 2005 in China

Qian, Liling; Liu, Cuiqing; Zhuang, Wanzhu; Guo, Yunxia; Yu, Jialin; Chen, Hanqiang; Wang, Sannan; Lin, Zhenlang; Xia, Shiwen; Ni, Liming; Liu, Xiaohong; Chen, Chao; Sun, Bo

doi:10.1542/peds.2006-2426

Cited by 57 publications

(54 citation statements)

References 18 publications

(26 reference statements)

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“…Current research also included meconium aspiration syndrome, because it is directly connected to the chain of events associated with perinatal asphyxia (12) , highlighting that this entity is classified as other respiratory conditions of the newborn as basic cause of death by the WHO (7) . Responsible for 10% of cases of respiratory failure (13) , aspiration of meconium caused the death of practically one baby in every five early neonatal avoidable deaths in the state of São Paulo, stressing the high mortality rate in emerging countries such as in China, where the syndrome was responsible for 39% of deaths from respiratory failure in the early neonatal period (14) .…”

Section: Discussionmentioning

confidence: 99%

Asfixia perinatal associada à mortalidade neonatal precoce: estudo populacional dos óbitos evitáveis

Daripa

Caldas

Flores

et al. 2013

Rev. paul. pediatr.

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Perinatal asphyxia associated with early neonatal mortality: populational study of avoidable deathsResults: During the three years, 1.71 deaths per 1,000 live births were associated with perinatal asphyxia, which corresponded to 22% of the early neonatal deaths. From the 2,873 avoidable deaths, 761 (27%) occurred in São Paulo city; 640 (22%), in the metropolitan region of São Paulo city; and 1,472 (51%), in the countryside of the state. In the first two regions, deaths were more frequent in public hospitals, among newborns with gestational age of 36 weeks or less, and among babies weighing less than 2500g. In the countryside, mortality was more frequent in philanthropic hospitals, in term newborns and in neonates weighing over 2500g. Most of these neonates were born during daytime in their hometown and died at the same institution in which they were born within the first 24 hours after delivery. Meconium aspiration syndrome was related to 18% of the deaths.Conclusions: Perinatal asphyxia is a frequent contributor to the avoidable early neonatal death in the state with the highest gross domestic product per capita in Brazil, and it shows the need for specific interventions with regionalized focus during labor and birth care.

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Section: Discussionmentioning

confidence: 99%

Asfixia perinatal associada à mortalidade neonatal precoce: estudo populacional dos óbitos evitáveis

Daripa

Caldas

Flores

et al. 2013

Rev. paul. pediatr.

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“…The mortality rate in newborn infants has been reported between 10 and 40% (4,5). In our study, 14.3% of newborn infants, diagnosed with meconium aspiration syndrome, died.…”

Section: Discussionmentioning

confidence: 45%

“…Meconium aspiration syndrome (MAS) occurs in 1.3% of live births and symptoms range from mild respiratory distress syndrome with auto recovery to progressive respiratory failure, complications and death, and in the most severe cases, respiratory distress, hypoxia, hypercapnia and respiratory acidosis increase, requiring intensive care and mechanical ventilation (1)(2)(3), and 10 to 40% of cases result in infant's death (4,5).…”

Section: Introductionmentioning

confidence: 99%

An Investigation of the Mortality Rate and Risk Factors in Newborn Infants With Meconium Aspiration Syndrome

et al. 2016

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Background: One of the serious challenges facing neonatal medicine is meconium aspiration syndrome, delays in the treatment of which can lead to high mortality. Objectives: This study was designed and conducted with the aim of determining the mortality rate and risk factors affecting this rate in newborn infants with meconium aspiration syndrome. Methods: This study was conducted as a retrospective descriptive research on newborn infants with meconium aspiration syndrome hospitalized at the neonatal intensive care unit (NICU) of Fatemieh and Be'sat hospitals in Hamadan city during a 10-year period from 2004 to 2014. Demographic information of the mother and the newborn, hospitalization course, the need for mechanical ventilation, and complications and outcomes of disease were extracted and were analyzed using the SPSS software version 22. Results: Sixty-three newborn infants, diagnosed with meconium aspiration syndrome, were entered in this study, 40% of them were male, 85.7% wighed more than 2500 g, and 17.5% were post term, 25.3% had a five-minute Apgar Score (AS5min) of less than seven, 39.6% were nonvigorous at birth, 31.8% needed to be placed on mechanical ventilation, and 14.3% died during the hospitalization course. There was a significant relationship between the need for mechanical ventilation, nonvigorous state at the birth, complications of disease and mortality rate. Conclusions: Despite the progress made in medicine, meconium aspiration syndrome is still one of the causes of newborn infants' mortality. The mortality and morbidity rates can be reduced by improvement in perinatal care, prevention of post term delivery, timely caesarean and effective neonatal resuscitation at birth.

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“…[1] HRF, usually secondary to meconium aspiration, pneumonia with or without sepsis, respiratory distress syndrome (RDS) and primary pulmonary hypertension of the newborn (PPHN), is the most common reason for routine mechanical ventilation. However, long-term ventilator support may lead to acute and chronic lung injury.…”

Section: Introductionmentioning

confidence: 99%

Exhaled nitric oxide in neonates with or without hypoxemic respiratory failure

Liu

Gao

Wu³

et al. 2011

World Journal of Emergency Medicine

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Neonatal Respiratory Failure: A 12-Month Clinical Epidemiologic Study From 2004 to 2005 in China

Abstract: Neonatal respiratory failure in the NICU of the provincial cities of China has high mortality and cost that are linked to geographic variability, a male predominance, and low proportion of very preterm infants, characteristic of sociocultural confounding background.

Cited by 57 publications

References 18 publications

Asfixia perinatal associada à mortalidade neonatal precoce: estudo populacional dos óbitos evitáveis

Asfixia perinatal associada à mortalidade neonatal precoce: estudo populacional dos óbitos evitáveis

An Investigation of the Mortality Rate and Risk Factors in Newborn Infants With Meconium Aspiration Syndrome

Exhaled nitric oxide in neonates with or without hypoxemic respiratory failure

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