Neonatal programming with sex hormones: Effect on expression of dopamine D1 receptor and neurotransmitters release in nucleus accumbens in adult male and female rats

Elgueta-Reyes, Maximiliano; Martínez-Pinto, Jonathan; Renard, Georgina M.; Sotomayor‐Zárate, Ramón

doi:10.1016/j.ejphar.2021.174118

Cited by 6 publications

(2 citation statements)

References 62 publications

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“…Sex hormone receptors are present from early stages of development, 107 and both androgen and estrogen(α) receptors are widely expressed in midbrain dopamine neurons, 108,109 where they contribute to neurophysiological and behavioral redouts under the control of the dopamine system. 108,109 Testosterone, but not estrogen, increases dopamine synthesis and metabolism in the adolescent rat brain, changing these neurons toward hyperdopaminergic phenotypes. 109 Interestingly, the strain of rats used in our studies (i.e., Sprague-Dawley) feature higher plasma testosterone concentrations than females across development, especially during the first postnatal days and juvenile period.…”

Section: Prenatal Cannabis Exposure Elicits Sex-and Age-specific Psyc...mentioning

confidence: 99%

“…One explanation might be that sex steroids determine a “resilient” phenotype through their organizational effects. Sex hormone receptors are present from early stages of development, 107 and both androgen and estrogen(α) receptors are widely expressed in midbrain dopamine neurons, 108,109 where they contribute to neurophysiological and behavioral redouts under the control of the dopamine system 108,109 . Testosterone, but not estrogen, increases dopamine synthesis and metabolism in the adolescent rat brain, changing these neurons toward hyperdopaminergic phenotypes 109 .…”

Section: Prenatal Cannabis Exposure Elicits Sex‐ and Age‐ Specific Ps...mentioning

confidence: 99%

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Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Frau

Melis

2023

J Neuroendocrinology

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Sociocultural attitudes towards cannabis legalization contribute to the common misconception that it is a relatively safe drug and its use during pregnancy poses no risk to the fetus. However, longitudinal studies demonstrate that maternal cannabis exposure results in adverse outcomes in the offspring, with a heightened risk for developing psychopathology. One of the most reported psychiatric outcomes is the proneness to psychotic‐like experiences during childhood. How exposure to cannabis during gestation increases psychosis susceptibility in children and adolescents remains elusive. Preclinical research has indicated that in utero exposure to the major psychoactive component of cannabis, delta‐9‐tetrahydrocannabinol (THC), deranges brain developmental trajectories towards vulnerable psychotic‐like endophenotypes later in life. Here, we present how prenatal THC exposure (PCE) deregulates mesolimbic dopamine development predisposing the offspring to schizophrenia‐relevant phenotypes, exclusively when exposed to environmental challenges, such as stress or THC. Detrimental effects of PCE are sex‐specific because female offspring do not display psychotic‐like outcomes upon exposure to these challenges. Moreover, we present how pregnenolone, a neurosteroid that showed beneficial properties on the effects elicited by cannabis intoxication, normalizes mesolimbic dopamine function and rescues psychotic‐like phenotypes. We, therefore, suggest this neurosteroid as a safe “disease‐modifying” aid to prevent the onset of psychoses in vulnerable individuals. Our findings corroborate clinical evidence and highlight the relevance of early diagnostic screening and preventative strategies for young individuals at risk for mental diseases, such as male PCE offspring.

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Section: Prenatal Cannabis Exposure Elicits Sex-and Age-specific Psyc...mentioning

confidence: 99%

Section: Prenatal Cannabis Exposure Elicits Sex‐ and Age‐ Specific Ps...mentioning

confidence: 99%

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Frau

Melis

2023

J Neuroendocrinology

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Neurosteroids and the mesocorticolimbic system

Seib

Tobiansky

Meitzen

et al. 2023

Neuroscience & Biobehavioral Reviews

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Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction.

Venegas,

Rosas,

Delgado

et al. 2024

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Neonatal programming with sex hormones: Effect on expression of dopamine D1 receptor and neurotransmitters release in nucleus accumbens in adult male and female rats

Cited by 6 publications

References 62 publications

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Neurosteroids and the mesocorticolimbic system

Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction.

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