Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction.

Venegas, Francisca C.; Rosas, Daniela; Delgado, Nicol; Estay-Olmos, Camila; Iturriaga-Vásquez, Patricio; Rivera-Meza, Mario; Torres, Gonzalo E.; Renard, Georgina M.; Sotomayor-Zárate, Ramón

doi:10.1016/j.pnpbp.2024.111001

Progress in Neuro-Psychopharmacology and Biological Psychiatry

2024

DOI: 10.1016/j.pnpbp.2024.111001

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Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction.

Francisca C. Venegas,

Daniela Rosas,

Nicol Delgado

et al.

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2024

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Sex Differences in Alcohol Use: Is It All About Hormones?

Maddern,

Ursich,

Bailey

et al. 2024

Endocrinology

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Risky alcohol use and alcohol use disorders (AUD) are a rising problem in women, yet a major disparity in our understanding of what drives alcohol consumption in women remains. Historically biomedical research has focused on male subjects, however, recent increases in reporting of females, have highlighted major differences between the sexes. Here we review the current literature of the impact of gonadal steroid hormones (estrogens, androgens and progestins), neurosteriods and neurobiological factors on alcohol use in clinical and preclinical studies of both sexes. Further, we briefly discuss how fundamental sex differences in genetics, metabolism, neuroimmune and stress responses may influence sex differences in alcohol intake. Comparing the sexes could aid in the discovery of novel therapeutics to treat AUD, and implementation of current treatment options in women.

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Sex Differences in Alcohol Use: Is It All About Hormones?

Maddern,

Ursich,

Bailey

et al. 2024

Endocrinology

View full text Add to dashboard Cite

show abstract

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Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction.

Cited by 1 publication

References 47 publications

Sex Differences in Alcohol Use: Is It All About Hormones?

Sex Differences in Alcohol Use: Is It All About Hormones?

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