Neonatal pemphigus vulgaris passively transmitted from a clinically asymptomatic mother

Pemphigus and pregnancy: A 23-year experience

“…[18] The maternal disease was not always severe; it may be mild as in our case or even inactive. [5,31,32] Although there is no prospective or cohort study defining the best drug regimen during pregnancy in PV, prednisolone and azathioprine are considered safe therapeutic options in this context. [20] Topical steroids and intralesional steroid injection (triamcinolone acetonide 10-20 mg/mL around the lesion) can be used in mild cases.…”

Neonatal pemphigus vulgaris

“…Currently, the levels of serum anti‐Dsg1 and anti‐Dsg3 autoantibodies in pemphigus have been standardized so as to evaluate the state of the disease and direct the treatments 25 . There have been five case reports, including the present one, in which the anti‐Dsg autoantibodies were examined 5,16,26,27 (Table 2). However, only three out of the five cases, including the present one, measured the serum anti‐Dsg autoantibodies quantitatively 16,26 .…”

Neonatal pemphigus in an infant born to a mother with serologic evidence of both pemphigus vulgaris and gestational pemphigoid

“…Neonatal pemphigus vulgaris has been reported to be passively transmitted from a clinically asymptomatic mother, 13,14 but there have been no reports of neonatal gestational pemphigoid transferred from an asymptomatic mother. It is possible the mother in this case had subclinical asymptomatic gestational pemphigoid, as evidenced by complement fixing IgG basement membrane zone antibodies in her serum.…”

“…The prevalence of BP 180 and BP 230 autoantibodies was determined to be 7.1% in one population-based epidemiological study. 13 Some pemphigus vulgaris sera contain BP 180 antibodies that react with both the intracellular and extracellular structures of desmosomes. 14 Serum from a patient with paraneoplastic pemphigus has also been shown to demonstrate antibodies to desmoglein 3, desmoglein 1, and anti-BP 180 antibodies.…”