Neonatal outcomes following exposure in utero to fallout from Chernobyl

Hatch, Maureen; Little, Mark P.; Brenner, Alina V.; Cahoon, Elizabeth K.; Tereshchenko, Valery P.; Chaikovska, L.V.; Pasteur, I.P.; Likhtarov, Illya; Bouville, André; Shpak, Victor; Bolshova, O.V.; Zamotayeva, Galyna; Grantz, Katherine L.; Sun, Liping; Mabuchi, Kiyóhiko; Albert, Paul S.; Тronko, М.D.

doi:10.1007/s10654-017-0299-y

Cited by 24 publications

(18 citation statements)

References 39 publications

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“…This analysis showed a dose-dependent reduction in head and chest circumference with a fetal dose dependent increase in gestational length (0.5 weeks/Gy) but not an increase in birth weight. They concluded that the observed effects were consistent with radiation effects among utero-exposed infants of Japanese atomic bomb survivors [40]. A team led by Prof. Eugenia Stepanova in Kiev examined the health outcomes of intra-uterine irradiation associated with Chernobyl exposure among mothers with acute and chronic exposure and compared them with a control group of children presumably non-exposed.…”

Section: A Review Of Reproductive Outcomes Among Chernobyl-exposed Pomentioning

confidence: 73%

Reproductive Effects of Exposure to Low-Dose Ionizing Radiation: A Long-Term Follow-Up of Immigrant Women Exposed to the Chernobyl Accident

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Sergienko

Gutvirtz

et al. 2020

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The Chernobyl accident in 1986 spread ionizing radiation over extensive areas of Belarus and Ukraine, leading to adverse health effects in exposed children. More than 30 years later, exposed children have grown and became parents themselves. This retrospective study from Israel was aimed to evaluate whether Chernobyl-exposed women are at higher risk for adverse reproductive outcomes. Exposed immigrants were identified as high or low exposure based on Caesium-137 soil contamination levels registered in the town they lived in. The exposed group was age matched with three comparison groups: non-exposed immigrant women from the Former Soviet Union (FSU) excluding Belarus and the Ukraine, immigrants from other countries (Non FSU) and Israeli-born women at a ratio of 1:10. Chernobyl-exposed women were more likely to be nulliparous and have fewer children (2.1 + 0.8 vs. 3.1 + 1.8, p < 0.001), were more likely to undergo fertility treatments (8.8% vs. 5.8%, adjusted OR = 1.8, 95%CI 1.04–3.2, p = 0.036), and were also more likely to have anemia after delivery (49.4% vs. 36.6%, OR = 1.7, 95%CI 1.2–2.3, p = 0.001), compared to women in the combined comparison groups. The overall fertility of Chernobyl-exposed women seems to be reduced as reflected by the lower number of children and their greater need for fertility treatments.

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Section: A Review Of Reproductive Outcomes Among Chernobyl-exposed Pomentioning

confidence: 73%

Reproductive Effects of Exposure to Low-Dose Ionizing Radiation: A Long-Term Follow-Up of Immigrant Women Exposed to the Chernobyl Accident

Cwikel

Sergienko

Gutvirtz

et al. 2020

JCM

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“…Therefore, it is of no surprise that no unequivocal evidence has been obtained yet. For example, in a study mentioned in the introduction [31], there was no statistically signi cant effect (pvalue > 0.1) of fetal dose on birth weight in 2,582 in utero-exposed individuals from northern Ukraine for whom estimates of fetal thyroid I-131 dose were available. Because of this relatively small population size (n=2,582), the statistical power for detecting a relevant 10% increase in LBW prevalence, which prevalence is itself in the range of 10%, achieves only 40%.…”

Section: Discussionmentioning

confidence: 94%

Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study

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Clinic²

2020

Preprint

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Background: Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated counts of surgeries for cryptorchidism and congenital heart malformations were observed throughout Japan from 2012 onward. The thyroid cancer detection rate (2011 to 2016) was associated with the dose-rate at the municipality level in the Fukushima prefecture. Since the birth weight is a simple and objective indicator for gestational development and pregnancy outcome, the question arises whether the annual birth weight distribution was distorted in a dose-rate-dependent manner across Japan after Fukushima. Methods: The Japanese Ministry of Health, Labour, and Welfare provides prefecture-specific annual counts for 26.158 million live births from 1995 to 2018, of which 2.366 million births (9.04%) with weights < 2500 g. Prefecture-specific spatiotemporal trends of the low birth weight proportions were analyzed. Logistic regression allowing for level-shifts from 2012 onward was employed to test whether those level-shifts were proportional to the prefecture-specific dose-rates derived from Cs-137 deposition in the 47 Japanese prefectures. Results: The overall trend of the low birth weight prevalence (LBWp) in Japan discloses a jump in 2012 with a jump odds ratio (OR) 1.020, 95%-confidence interval (1.003,1.037), p-value 0.0246. A logistic regression of LBWp on the additional dose-rate after the FDNPP accidents adjusted for prefecture-specific spatiotemporal base-line trends yields an OR per µSv/h of 1.098 (1.058, 1.139), p-value < 0.0001. Further adjusting the logistic regression for the annual population size and physician density of the prefectures, as well as for the counts of the dead, the missing, and the evacuees due to earthquake and tsunami (as surrogate measures for medical infrastructure and stress) yields an OR per µSv/h of 1.109 (1.032, 1.191), p-value 0.0046.Conclusions: This study shows increased low birth weight prevalence related to Cs-137 deposition and the corresponding additional dose-rate in Japan from 2012 onward. Previous evidence suggesting compromised gestational development and pregnancy outcome under elevated environmental ionizing radiation exposure is corroborated.

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“…Therefore, it is of no surprise that no unequivocal evidence has been obtained yet. For example, in a study mentioned in the introduction [31], there was no statistically signi cant effect (p-value > 0.1) of fetal dose on birth weight in 2,582 in-utero-exposed individuals from northern Ukraine for whom estimates of fetal thyroid I-131 dose were available. Because of this relatively small population size (n=2,582), the statistical power for detecting a relevant 10% increase in LBW prevalence, which prevalence is itself in the range of 10%, achieves only 40%.…”

Section: Discussionmentioning

confidence: 94%

Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study

Scherb

Clinic²

2020

Preprint

View full text Add to dashboard Cite

Background: Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated counts of surgeries for cryptorchidism and congenital heart malformations were observed throughout Japan from 2012 onward. The thyroid cancer detection rate (2011 to 2016) was associated with the dose-rate at the municipality level in the Fukushima prefecture. Since the birth weight is a simple and objective indicator for gestational development and pregnancy outcome, the question arises whether the annual birth weight distribution was distorted in a dose-rate-dependent manner across Japan after Fukushima. Methods: The Japanese Ministry of Health, Labour, and Welfare provides prefecture-specific annual counts for 26.158 million live births from 1995 to 2018, of which 2.366 million births (9.04%) with weights < 2500 g. Prefecture-specific spatiotemporal trends of the low birth weight proportions were analyzed. Logistic regression allowing for level-shifts from 2012 onward was employed to test whether those level-shifts were proportional to the prefecture-specific dose-rates derived from Cs-137 deposition in the 47 Japanese prefectures. Results: The overall trend of the low birth weight prevalence (LBWp) in Japan discloses a jump in 2012 with a jump odds ratio (OR) 1.020, 95%-confidence interval (1.003,1.037), p-value 0.0246. A logistic regression of LBWp on the additional dose-rate after the FDNPP accidents adjusted for prefecture-specific spatiotemporal base-line trends yields an OR per µSv/h of 1.098 (1.058, 1.139), p-value < 0.0001. Further adjusting the logistic regression for the annual population size and physician density of the prefectures, as well as for the counts of the dead, the missing, and the evacuees due to earthquake and tsunami (as surrogate measures for medical infrastructure and stress) yields an OR per µSv/h of 1.109 (1.032, 1.191), p-value 0.0046. Conclusions: This study shows increased low birth weight prevalence related to the Cs-137 deposition and the corresponding additional dose-rate in Japan from 2012 onward. Previous evidence suggesting compromised gestational development and pregnancy outcome under elevated environmental ionizing radiation exposure is corroborated.

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Neonatal outcomes following exposure in utero to fallout from Chernobyl

Cited by 24 publications

References 39 publications

Reproductive Effects of Exposure to Low-Dose Ionizing Radiation: A Long-Term Follow-Up of Immigrant Women Exposed to the Chernobyl Accident

Reproductive Effects of Exposure to Low-Dose Ionizing Radiation: A Long-Term Follow-Up of Immigrant Women Exposed to the Chernobyl Accident

Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study

Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study

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