Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data

Oberlander, Tim F.; Warburton, William; Misri, Shaila; Aghajanian, Jaafar; Hertzman, Clyde

doi:10.1001/archpsyc.63.8.898

Cited by 485 publications

(486 citation statements)

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“…During pregnancy, 15% to 20% of women experience mood disorders (e.g., depression) and between 5% and 13% of pregnant women are treated with an antidepressant drug (13,14). Serotonin reuptake inhibitor (SRI) antidepressants are among the most commonly used drugs during pregnancy (14).…”

mentioning

confidence: 99%

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Weikum

Oberlander

Hensch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Language acquisition reflects a complex interplay between biology and early experience. Psychotropic medication exposure has been shown to alter neural plasticity and shift sensitive periods in perceptual development. Notably, serotonin reuptake inhibitors (SRIs) are antidepressant agents increasingly prescribed to manage antenatal mood disorders, and depressed maternal mood per se during pregnancy impacts infant behavior, also raising concerns about long-term consequences following such developmental exposure. We studied whether infants' language development is altered by prenatal exposure to SRIs and whether such effects differ from exposure to maternal mood disturbances. Infants from non-SRI-treated mothers with little or no depression (control), depressed but non-SRI-treated (depressed-only), and depressed and treated with an SRI (SRI-exposed) were studied at 36 wk gestation (while still in utero) on a consonant and vowel discrimination task and at 6 and 10 mo of age on a nonnative speech and visual language discrimination task. Whereas the control infants responded as expected (success at 6 mo and failure at 10 mo) the SRI-exposed infants failed to discriminate the language differences at either age and the depressed-only infants succeeded at 10 mo instead of 6 mo. Fetuses at 36 wk gestation in the control condition performed as expected, with a response on vowel but not consonant discrimination, whereas the SRI-exposed fetuses showed accelerated perceptual development by discriminating both vowels and consonants. Thus, prenatal depressed maternal mood and SRI exposure were found to shift developmental milestones bidirectionally on infant speech perception tasks.L anguage, our most quintessential human characteristic, involves a complex interplay between biology and experience. At birth, infants possess an initial preparedness for language and a developmental readiness that supports learning any of the world's languages (1-3), yet also already show privileged processing to the native language from prenatal listening experience (4-6). During the following weeks and months of life, infants become progressively attuned to the properties of their native language, including its rhythmical and segmental (e.g., consonant) information (reviewed in refs. 7 and 8). The high degree of regularity in the timing of sequential tuning to properties of the native language suggests a series of critical or sensitive periods, i.e., points in development when the system is maximally influenced by input.The timing of onset of these sensitive periods seems to be maturationally constrained. Infants born 3 mo preterm attune to the phonetic properties (9) of their native language at the same gestational age as full-term infants, not according to the number of months of postnatal listening experience. Such maturational constraints can protect development: ensuring the optimal consecutive stabilization of the perceptual components that contribute in a step-wise fashion to language acquisition (10). However, it is known from research i...

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mentioning

confidence: 99%

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Weikum

Oberlander

Hensch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

168

107

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“…Exposure to SSRIs in utero was associated with increased incidence of low birth weight and rates of respiratory distress. 15 However, this study is limited by the absence of any direct measure of depression. Although an attempt was made to compare groups of women with an equal severity of depression (by measuring contacts with psychiatric services), women with more severe depression are more likely to be prescribed antidepressants, and therefore a direct effect of depression on the developing physiology of the foetus could account for the association found between antidepressant medication and the negative foetal outcomes.…”

Section: Impact Of Antidepressant Medication On the Developing Foetusmentioning

confidence: 97%

“…14 A study of population health data of over 100 000 pregnant women and their infants in Canada, showed that the offspring of women whose pregnancies were complicated by untreated depression, had statistically significant lower birth weights, higher rates of preterm birth, and more feeding and respirator y dif ficulties, than women who were not depressed. 15 Other studies have shown longer lasting adverse effects, with antenatal depression being associated with unsettled behaviour and sleep problems in neonates, 16 fearful infant temperament, 17 developmental delay at 18 months 18 and depression in adolescents. 19 The adverse ef fects of antenatal depression may even persist into adult life, as the above evidence suggests an adverse intrauterine environment, as manifested by low birth weight, small for gestational age babies and preterm birth, although the evidence for association with the former effects is less than that for preterm birth.…”

Section: Impact Of Depression On the Developing Foetus And Offspringmentioning

confidence: 99%

Management of depression during pregnancy

Osborne¹,

O’Keane²

2009

Prog Neurol Psychiatry

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“…Stres prenatal merupakan penyakit yang dialami oleh 15-20 % wanita selama periode kehamilan atau di awal kehamilan (Bennett el al., 2004a,b;Oberlander et al, 2006). Akibat yang ditimbulkan oleh stres prenatal seperti berat badan lahir rendah (BBLR), resiko prematur meningkat dan neonatal abnormality dapat membahayakan kesehatan fetus.…”

Section: Pendahuluanunclassified

Mozart KV 448 Menurunkan Densitas dan Aktivitas Neuroglia Hipokampus Mencit (Mus musculus) Selama Stres Prenatal No. 416-KE

Kusumarini

Yustinasari

Hestianah

et al. 2017

Jurnal Sain Veteriner

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The aim of this research was to explore the influence of Mozart KV 448 classical music therapy to the neuroglia cells of mice's hippocampus that were exposed to stress during prenatal. This research were employing twenty female mices and twenty male mices. Female mices were estrus synchronized with PMSG and hCG then monomating to the males. Pregnant females were then divided into four groups (P0, P1, P2, P3). P0 was as control, P1 was treated by one minute forced swim test, P2 was treated by one minute forced swim test followed by thirty minutes classical music Mozart KV 448 and P3 was treated by one minute forced swim test followed by sixty minutes classical music Mozart KV 448. This research was carried out for twenty-one days during gestation period. The neuroglia density result was analyzed using ANOVA and Duncan test. The neuroglia activity result was analyzed using Kruskal wallis test and Z test. The histology reading showed degradation of density and activity of hippocampus neuroglia.Keywords: prenatal stress, classical music, Mozart KV 448, neuroglia, hippocampus AbstrakTujuan dari penelitian ini adalah untuk mengetahui pengaruh terapi musik klasik Mozart KV 448 pada densitas dan aktivitas dari sel neuroglia hipokampus anak mencit yang terpapar stres selama prenatal. Penelitian ini menggunakan 20 mencit betina dan 20 mencit jantan. Mencit betina kemudian di sinkronisasi estrus dengan PMSG dan hCG setelah itu dilakukan mono mating. Mencit betina yang positif bunting di bagi menjadi empat kelompok (P0, P1, P2, P3). P0 sebagai kontrol tidak diberikan perlakuan apapun, P1 diberikan terapi forced swim test selama satu menit, P2 diberikan terapi forced swim test selama satu menit diikuti musik klasik Mozart KV 448 selama 30 menit dan P3 diberikan terapi forced swim test selama satu menit diikuti musik klasik Mozart KV 448 selama 60 menit. Penelitian ini dilakukan selama 21 hari periode kebuntingan. Analisis data pada densitas neuroglia menggunakan ANOVA dan uji Duncan selanjutnya untuk aktivitas neuroglia data yang diperoleh berupa skor nilai tingkat perubahan aktivitas antar neuroglia sehingga menggunakan uji Kruskal wallis dan uji Z. Hasil gambaran histologi dari penelitian ini menunjukkan penurunan terhadap densitas dan aktivitas neuroglia hipokampus.

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Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data

Abstract: With linked population health data and propensity score matching, prenatal SE-D exposure was associated with an increased risk of low birth weight and respiratory distress, even when maternal illness severity was accounted for.

Cited by 485 publications

References 74 publications

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception

Management of depression during pregnancy

Mozart KV 448 Menurunkan Densitas dan Aktivitas Neuroglia Hipokampus Mencit (Mus musculus) Selama Stres Prenatal No. 416-KE

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