Neonatal outcome in pregnancy hypotiroidee women

Luisi, Stefano; Giorgi, Matteo; Riggi, Silvia; Messina, Gabriele; Severi, Filiberto Maria

doi:10.1080/09513590.2019.1706083

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…Moreover, hypertension was associated with an increased risk of term rather than preterm PROM [70]. In turn, hypothyroidism in pregnancy was correlated with a slight FGR, a higher risk of PROM and the development of hypertension and GDM [62]. Similarly, threatened miscarriage was associated with much more frequent PROM, preterm labor and low-birth-weight newborns [71].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we corrected the results for the following complications of pregnancy: asthma and respiratory infections, bleeding, DM, hypertension, hypothyroidism, serological conflict, threatened miscarriage and urogenital infections. So far, many studies have described the relationship between these diseases and the occurrence of PROM [61][62][63][64][65]. DM-adjusted analyses showed that CSF2 rs25881 CT heterozygotes are significantly more common in pPROM compared to tPROM cases.…”

Section: Discussionmentioning

confidence: 99%

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Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes

Wujcicka

Kacerovský

Krekora

et al. 2021

Genes

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A prelabor rupture of membranes (PROM) and its subtypes, preterm PROM (pPROM) and term PROM (tPROM), are associated with disturbances in the hemostatic system and angiogenesis. This study was designed to demonstrate the role of single nucleotide polymorphisms (SNPs), localized in CSF2 (rs25881), FLT1 (rs722503), TFPI (C-399T) and TLR9 (rs352140) genes, in PROM. A population of 360 women with singleton pregnancy consisted of 180 PROM cases and 180 healthy controls. A single-SNP analysis showed a similar distribution of genotypes in the studied polymorphisms between the PROM or the pPROM women and the healthy controls. Double-SNP TT variants for CSF2 and FLT1 polymorphisms, CC variants for TLR9 and TFPI SNPs, TTC for CSF2, FLT1 and TLR9 polymorphisms, TTT for FLT1, TLR9 and TFPI SNPs and CCCC and TTTC complex variants for all tested SNPs correlated with an increased risk of PROM after adjusting for APTT, PLT parameters and/or pregnancy disorders. The TCT variants for the CSF2, FLT1 and TLR9 SNPs and the CCTC for the CSF2, FLT1, TLR9 and TFPI polymorphisms correlated with a reduced risk of PROM when corrected by PLT and APTT, respectively. We concluded that the polymorphisms of genes, involved in hemostasis and angiogenesis, contributed to PROM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes

Wujcicka

Kacerovský

Krekora

et al. 2021

Genes

View full text Add to dashboard Cite

show abstract

“…Although we adjusted the range of possible confounders in the multivariable logistic regression model, residual confounding was unavoidable as we did not investigate infection or trauma before or at delivery, the diseased condition of the membrane itself, and the polymorphisms of genes involved in hemostasis and angiogenesis contributing to PROM [28]. Although there has been no report on SIC and PROM, studies on maternal thyroid dysfunction and the risk of PROM have reported inconsistent findings [29,30]. The findings remain to be validated in future prospective studies.…”

Section: Sic and Pregnancy Outcomesmentioning

confidence: 99%

Associations of Maternal Serum Iodine Concentration with Obstetric Complications and Birth Outcomes—Longitudinal Analysis Based on the Huizhou Mother–Infant Cohort, South China

Liu

Long

et al. 2023

Nutrients

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This study aimed to explore the temporal associations between maternal serum iodine concentration (SIC) and common pregnancy outcomes in Chinese women. Eligible singleton pregnant women aged 20–34 years were selected, and their fasting blood samples were collected during early (T1, n = 1101) and mid-pregnancy (T2, n = 403) for SIC testing by inductively coupled plasma mass spectrometry. Multivariable linear regression indicated that log10SIC at T1 (β = −0.082), T2 (β = −0.198), and their % change (β = −0.131) were inversely associated with gestational weight gain (GWG, all p < 0.05). Maternal log10SIC at both T1 (β = 0.077) and T2 (β = 0.105) were positively associated with the Apgar score at 1 min (both p < 0.05). Women in the third quartile (Q3) of SIC at T1 had a lower risk of small for gestational age (SGA, OR = 0.405, 95% CI: 0.198–0.829) compared with those in Q4. Restricted cubic spline regression suggested a U-shaped association between SIC and SGA risk, and SIC above 94 μg/L at T1 was the starting point for an increased risk of SGA. The risk of premature rupture of membrane (PROM) increased by 96% (OR = 1.960, 95% CI: 1.010–3.804) in Q4 compared to that in Q1. Our longitudinal data from an iodine-replete region of China indicated that high maternal SIC could restrict GWG and improve Apgar scores at delivery, but might increase the risk of SGA and PROM.

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“…These maternal diseases have repercussions on the health and well-being of a fetus, a newborn, and later a child at a physical and psychological level. Some of the offspring pathologies associated with the presence of maternal disease during pregnancy are the following: attention deficit hyperactivity disorder (ADHD); intrauterine growth retardation with several consequences for a baby s physical and psychological health in the short, medium, and long term; liver disease; bone marrow disorders; poor growth; and an increased risk of endocrine, nutritional, and metabolic disorders during adolescence and early adulthood [19][20][21][22][23][24][25].…”

Section: Effects Of Nutritional Status Of Pregnant Women On Maternal mentioning

confidence: 99%

Nutrition in Reproductive Health: Nutritional Conditioning Factors during Pregnancy and Its Impact on Health

et al. 2020

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During the gestational period, women need to have optimal health to meet fetal requirements for growth and development. Nutrition is one of the most important factors that can ensure a mother`s health and also that of their offspring. The role of maternal diet, before and during pregnancy, has been associated with adverse birth outcomes and a worsening of maternal health. Medical conditions that are closely related to dietary intake and may affect women before or during pregnancy have also been associated with the appearance of pathology in a newborn. To date, several studies have been carried out in order to identify the role of diet as a factor associated with child physiological and psychological health, both in the short and long term. Educating mothers regarding the influence of maternal dietary intake during pregnancy on infants’ health could represent a simple but effective target for public health policies to improve pregnancy nutrition, and therefore help to avoid newborn diseases through the development.

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Neonatal outcome in pregnancy hypotiroidee women

Cited by 6 publications

References 20 publications

Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes

Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes

Associations of Maternal Serum Iodine Concentration with Obstetric Complications and Birth Outcomes—Longitudinal Analysis Based on the Huizhou Mother–Infant Cohort, South China

Nutrition in Reproductive Health: Nutritional Conditioning Factors during Pregnancy and Its Impact on Health

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