Neonatal mouse testis-derived multipotent germline stem cells improve the cardiac function of acute ischemic heart mouse model

Application of mesenchymal stem cells for anti-senescence and clinical challenges

“…It has been mentioned before that senescence can lead to the occurrence of CVDs, such as myocardial infarction (MI), heart failure, and arteriosclerosis. It was reported that the transplantation of multipotent germline stem cells (mGSCs) derived from neonatal mouse tests into the hearts of mice with ischemic heart failure can improve cardiac function by promoting angiogenesis and delaying cellular senescence [ 157 ]. It was proven that embryonic stem cells (ESs) can be induced to differentiate into spontaneously beating cardiomyocytes in vitro [ 158 ].…”

Potential applications of germline cell-derived pluripotent stem cells in organ regeneration

“…57 The same group also demonstrated that transplantation of Flk1 + GPSCs directly into the heart of ischemic mice improved cardiac function. 58 Although 4 weeks after treatment, the number of cardiomyocytes derived from Flk1 + GPSCs were too small to account for the improvement in cardiac function, angiogenesis around ischemic area was enhanced compared to control group, and senescence was also remarkably diminished in the early phase of ischemia. 58 The present findings open new possibilities for basic research on cardiac development as well as cardiac regeneration.…”

“…58 Although 4 weeks after treatment, the number of cardiomyocytes derived from Flk1 + GPSCs were too small to account for the improvement in cardiac function, angiogenesis around ischemic area was enhanced compared to control group, and senescence was also remarkably diminished in the early phase of ischemia. 58 The present findings open new possibilities for basic research on cardiac development as well as cardiac regeneration. transplants in humans have been attempted by the use of human hepatocytes isolated from cadaveric livers.…”

Der Einfluss mechanischer Last auf das Potential multipotenter adulter Keimbahnstammzellen zur kardialen Regeneration

“…Zusammenfassend lässt sich also sagen, dass pluripotente Stammzellen ein großes Potential für zellbasierte Therapien haben, vor allem die hES-Zellen zeigten aussichtsreiche Resultate bezüglich der Regeneration von geschädigtem Herzgewebe (Goh et al 2005 (Coultas et al 2005;Kattman et al 2006;Yang et al 2008;Iwasa et al 2010). Aus hES-Zellen gewonnene KDR + Zellen zeigten in vitro und in vivo kardiovaskuläres Potential (Yang et al 2008).…”

“…Aus hES-Zellen gewonnene KDR + Zellen zeigten in vitro und in vivo kardiovaskuläres Potential (Yang et al 2008). In einer aktuellen Studie konnte beobachtet werden, dass Flk1 + multipotente Keimbahnstammzellen aus neonatalen Maushoden nach Injektion in MI-Mäuse zu einer Funktionsverbesserung des Herzens beitragen (Iwasa et al 2010).…”