Neonatal Meningitis: Can We Do Better?

Heath, Paul T; Okike, Ifeanyichukwu; Oeser, Clarissa

doi:10.1007/978-1-4614-0204-6_2

Cited by 55 publications

(77 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2, 10, 16 This is likely an underestimation of the true incidence, however. For infants in the intensive care nursery who are evaluated for sepsis, 30–50% do not have a lumbar puncture (LP) performed.…”

Section: Epidemiologymentioning

confidence: 99%

“…2, 8 In a prospective study including 444 cases of confirmed meningitis from 2001–2007, mortality in premature infants compared with term infants was >2-fold higher (26% vs. 10%, p < 0.01). 8 Up to 50% of infants with a history of meningitis will be neurologically impaired, with 25% having severe disability.…”

Section: Epidemiologymentioning

confidence: 99%

“…8 Up to 50% of infants with a history of meningitis will be neurologically impaired, with 25% having severe disability. 2, 8, 19 With advances in medical practices, the incidence and mortality associated with meningitis have declined over the past 40 years; however, morbidity remains unchanged. 19 …”

Section: Epidemiologymentioning

confidence: 99%

“…While overall incidence and mortality have declined over the last several decades, morbidity associated with neonatal meningitis remains virtually unchanged. 1, 2 Prevention strategies, adjunctive therapies, and improved diagnostic strategies have been the focus of recent research seeking to improve the outcomes. 3 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bacterial Meningitis in Infants

Boggess

Cohen‐Wolkowiez

2015

Clinics in Perinatology

206

267

View full text Add to dashboard Cite

SYNOPSIS Neonatal bacterial meningitis is an uncommon but devastating infection. Although the incidence and mortality have declined over the last several decades, morbidity among survivors remains high. The types and distribution of causative pathogens are related to birth gestational age, postnatal age, and geographic region. Confirming the diagnosis of meningitis can be difficult. Clinical signs are often subtle, and the lumbar puncture is frequently deferred in clinically unstable infants. When obtained, confirmatory testing with cerebrospinal fluid (CSF) culture is often compromised by antepartum or postnatal antibiotic exposure. While blood cultures and CSF parameters may be helpful in cases where the diagnosis is uncertain, bacterial meningitis occurs in infants without bacteremia and with normal CSF parameters. Newer tests such as the polymerase chain reaction are promising but require further study. Prompt treatment with appropriate antibiotics is essential to optimize outcomes. Successful efforts to prevent meningitis in infants have included the use of intrapartum antibiotic prophylaxis against Group B Streptococcus (GBS). Clinical trials investigating the use of a GBS vaccine for the prevention of neonatal GBS disease are ongoing.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bacterial Meningitis in Infants

Boggess

Cohen‐Wolkowiez

2015

Clinics in Perinatology

206

267

View full text Add to dashboard Cite

show abstract

“…Mortality rates of bacterial meningitis in adults remain at approximately 20% but rise to at least 40% for those older than age 60 (13). In neonates, S. agalactiae and E. coli are the most common agents of meningitis in North America (11), Australasia (14), and Europe (15). The morbidity rate of neonatal meningitis is up to 56%; if not treated, the mortality can approach 100% (16).…”

Section: Bacterial Meningitismentioning

confidence: 99%

Infectious Meningitis

Zueter

Zaiter

2015

Clinical Microbiology Newsletter

View full text Add to dashboard Cite

Infectious meningitis is a large public health concern, especially in children and immunocompromised patients. Although the epidemiology of meningitis has shown significant decline in past decades, partly due to the introduction of vaccines, outbreaks are still reported worldwide. Diagnosis of meningitis is of critical importance, and it is considered to be one of the most urgent of the microbiological medical emergencies. In order to improve the treatment strategy, various diagnostic methods have been developed to detect the presence of infectious agents that cause meningitis, as well as their antibiotic resistance patterns. This article aims to enhance the understanding of meningitis and to highlight the most current updates that describe outbreaks of meningitis and the subsequent investigations. We also describe the current diagnosis and treatment options. CMN

show abstract