Neonatal lupus

Robles, David T; Jaramillo, Lorena; Hornung, Robin L.

doi:10.5070/d37bk794qx

Cited by 3 publications

(4 citation statements)

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“…Se decide programar cesárea por sospecha de sufrimiento fetal y malformación cardiaca congénita. Nació de parto por cesárea, con líquido amniótico claro, sexo masculino, edad gestacional de36 semanas, peso al nacer de 2630 g, talla 46 cm, APGAR 8 1 -8 5 , frecuencia cardiaca al nacer de 60 latidos por minuto, no requirió reanimación, pasa a UCI Neonatal por bradicardia.…”

Section: Presentación De Casounclassified

“…Solo alrededor del 1% de los niños que reciben autoanticuerpos maternos van a desarrollar lupus neonatal y las mujeres con más frecuencia que los hombres; sin embargo, de acuerdo con diferentes informes hay una probabilidad del 18% al 25% que los hermanos nacidos después de un infante con lupus neonatal también desarrollarán la enfermedad (5) .…”

Section: Lupus Neonatalunclassified

“…La exposición al sol tiende a precipitar la erupción. Las erupciones cutáneas, en promedio, van a desaparecer seis meses después, cuando desaparecen los anticuerpos maternos (5) .…”

Section: Lupus Neonatalunclassified

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Neonatal Lupus: Case Report

Chirinos,

Muñoz,

Peralta

et al. 2014

Rev Peru Pediatr

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Se presenta el caso de un recién nacido con diagnóstico de Lupus Neonatal del Servicio de Neonatología del Hospital Nacional Dos de Mayo en Lima, el cual se sospechó por tener bradicardia severa y bloqueo aurículo ventricular de IIIo. Durante la etapa prenatal presentó bradicardia fetal con frecuencia cardiaca promedio de 80 latidos por minuto y test de bienestar fetal normal. La madre no presentó antecedentes patológicos. Nació por cesárea por sospecha de sufrimiento fetal o cardiopatía congénita, con líquido amniótico claro y APGAR 81 – 85. Cursa con frecuencia cardiaca que llegan a 60 latidos por minuto. El EKG evidenció bloqueo aurículo ventricular de IIIo, se realizó la investigación de las causas de bloqueo cardiaco de este tipo y se tuvo resultados positivos para IgG anti SSA/Ro. Al mes de vida se le colocó marcapasos cardiaco.

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Section: Presentación De Casounclassified

Section: Lupus Neonatalunclassified

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Neonatal Lupus: Case Report

Chirinos,

Muñoz,

Peralta

et al. 2014

Rev Peru Pediatr

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“…High levels of autoantibodies, immune complexes, inflammatory cells, and cytokines in autoimmune diseases can cause obstetric complications such as preterm birth (PD), fetal growth retardation (FGR), and early and unexplained fetal loss [ 9 , 10 ]. Transplacental transmission of autoantibodies from the 12th week of pregnancy may affect the immune system development of the fetus [ 11 ].…”

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confidence: 99%

Evaluation of fetal thymus size in maternal autoimmune diseases: systemic lupus erythematosus, Sjögren’s syndrome and antiphospholipid antibody syndrome

Hendem

Oluklu

Beşer

et al. 2023

Arch Gynecol Obstet

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Purpose To investigate the effect of inflammation on the fetal thymus-thoracic ratio (TTR) in pregnant women with systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS) and antiphospholipid antibody syndrome (APS). Method This prospective case–control study included 45 pregnant women with SLE, SS, and APS and 90 gestational age-matched healthy pregnant women between 24 and 37 gestational weeks. The ratio of the anteroposterior fetal thymus length to the transverse mediastinal length was calculated as the TTR in the study groups. Results Fetal TTR was significantly lower in the case group ( p < 0.001). Fetal TTR in the APS group was significantly lower than SS group ( p = 006). The patients using hydroxychloroquine (HCQ) had significantly higher fetal TTR compared to patients not using HCQ ( p = 0.004). A moderate negative correlation was found between the disease duration and fetal TTR ( r = − 0.552, p < 0.001). In predicting admission to the neonatal intensive unit care (NICU), a value of 0.31 was found for the fetal TTR with a sensitivity of 83.3% and a specificity of 69% Conclusion Maternal inflammation in pregnancies with autoimmune diseases may affect the intrauterine milieu of the fetus and cause a lower fetal TTR. Additionally, the lower level of fetal TTR may be more effective and beneficial for the clinician if combined with other risk factors in predicting NICU admission.

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Neonatal lupus erythematosus and its clinical variability

Inzinger

Salmhofer

Binder

2012

J Deutsche Derma Gesell

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Keywords• neonatal lupus erythematosus • newborn child • skin lesions • atrioventricular heart block Summary Neonatal lupus erythematosus (NLE) is a rare disease affecting newborns that is caused by maternal autoantibodies transmitted across the placenta. The disease may affect the skin, the heart, and rarely the hepatobiliary or hematological systems. A serious complication affecting some patients with NLE is atrioventricular heart block (AV block). The clinical picture of cutaneous NLE varies considerably. NLE presents with confluent, scaly, periorbital erythema, or erythematous infiltrated plaques with central vesicles and lesions resembling seborrheic eczema or fungal infection. In any newborn with such skin lesions, NLE should be included in the differential diagnosis. Dermatologists play an important role in the diagnosis. We review different skin lesions occurring in neonatal lupus erythematosus based on five patients from our own clinic.

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Neonatal lupus

Cited by 3 publications

References 0 publications

Neonatal Lupus: Case Report

Neonatal Lupus: Case Report

Evaluation of fetal thymus size in maternal autoimmune diseases: systemic lupus erythematosus, Sjögren’s syndrome and antiphospholipid antibody syndrome

Neonatal lupus erythematosus and its clinical variability

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