Neonatal Hyperbilirubinemia: Magnitude and Associated Etiologic Factors among Neonates Admitted at Tikur Anbessa Specialized Hospital, Ethiopia

Kassa, Roza Teshome; Gudeta, Hoffola; Assen, Zuriyash Mengistu; Demlew, Tefera Mulugeta; Teshome, Girum Sebsibe

doi:10.4172/2376-127x.1000384

Cited by 11 publications

(26 citation statements)

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“…The prevalence of neonatal hyperbilirubinemia varied greatly in the included studies, ranging from 4.9% (4) to 44.9% (9). However, our subgroup analysis based on study location showed that the highest pooled prevalence was observed from studies done in Ethiopia (41.4%; 95% CI: 33.9, 48.8).…”

Section: Discussionmentioning

confidence: 62%

“…Blood type incompatibility was another contributing factor for neonatal hyperbilirubinemia and their connection was reported in five studies included in our analyses (6,7,(9)(10)(11) . The pooled odds ratio was 3.3 (95% CI: 1.96, 5.72), suggesting that the risk of developing hyperbilirubinemia was 3.3 times higher among neonates with an incompatible blood type as compared to blood type-compatible infants (Figure 8).…”

Section: The Association Between Blood Type Incompatibility and Neonamentioning

confidence: 72%

“…The pooled prevalence of neonatal hyperbilirubinemia in sub-Saharan Africa was assessed using 10 studies involving a total of 12,327 participants. The prevalence of hyperbilirubinemia in these studies ranged from 4.9% (4) to 44.9% (9), and most used a cross-sectional study design. The minimum sample size was 91 participants in a study conducted at Awolowo University, Nigeria (16), while the largest sample size was 5229 participants from Nigeria (11).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The minimum sample size was 91 participants in a study conducted at Awolowo University, Nigeria (16), while the largest sample size was 5229 participants from Nigeria (11). All studies involved populations from sub-Saharan Africa, with six involving participants from Nigeria (6,8,10,11,16,17), two from Ethiopia (7,9), and one each from Zimbabwe (5), and Congo (4). Regarding the sampling technique employed, six of the studies (7-9, 16-18) used consecutive sampling to select study participants.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Although G6PD deficiency and blood group incompatibility are widely regarded as risk factors for hyperbilirubinemia, the literature does show some inconsistencies (7)(8)(9)(10)(11)(12)(13)(14). For instance, several studies from sub-Saharan African countries (7,(9)(10)(11) have indicated that G6PD deficiency and blood incompatibility are associated with an increased risk of neonatal jaundice. However, another study showed that they were not associated with jaundice (12).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

Aynalem

Mulu

Akalu

et al. 2020

Preprint

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Background: Severe indirect hyperbilirubinemia is a silent cause of newborn disease and death worldwide. However, studies of the disease in sub-Saharan Africa are highly variable with respect to its prevalence. Hence, this study aimed to estimate the overall magnitude of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase (GP6D) deficiency and blood type incompatibility in sub-Saharan Africa.Methods: PubMed, Scopus, Google Scholar, and the Cochrane Review were systematically searched online to retrieve hyperbilirubinemia-related articles. All observational studies reported the prevalence of hyperbilirubinemia in sub-Saharan Africa were included for analysis and excluded if the study failed to determine the desired outcome. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed. Heterogeneity across the included studies was evaluated using the inconsistency index (I2). Publication bias was examined by funnel plot and the Egger’s regression test. The random-effect model was fitted to estimate the pooled prevalence of neonatal hyperbilirubinemia among patients in Sub Saharan Africa. The meta-analysis was performed using the STATA™ version 14 software.Results: A total of 30,486 studies were collected from the different databases and 10 articles were included for the final analysis. The overall magnitude of neonatal hyperbilirubinemia was 28.08 % (95% CI: (20.23, 35.94)) in sub-Saharan Africa. Neonates with G6PD deficiency were 2.42 times (95% CI: 1.64, 3.56) more likely to develop hyperbilirubinemia as compared to infants with normal G6PD levels. Moreover, the risk of developing hyperbilirubinemia was 3.3 times (95% CI: 1.96, 5.72) higher among neonates that had a blood type that was incompatible with their mother’s.Conclusion: The failure to prevent and screen G6PD deficiency and blood type incompatibility with their mother’s results in high burden of neonatal hyperbilirubinemia in sub-Saharan Africa. Therefore, early identification and care strategies should be developed to the affected neonates with G6PD deficiency and blood type incompatibility with their mother’s to address long-term medical and scholastic damages among those exposed to severe hyperbilirubinemia

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Section: Discussionmentioning

confidence: 62%

Section: The Association Between Blood Type Incompatibility and Neonamentioning

confidence: 72%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

Aynalem

Mulu

Akalu

et al. 2020

Preprint

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Glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice in Africa; systematic review and meta-analysis

Kassahun

Tunta

Abera

et al. 2023

Heliyon

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Retrospective Analysis of Neonatal Hyperbilirubinemia at Hiwot Fana Specialized Hospital, Ethiopia: Prevalence, Associated Factors, and Treatment Outcomes

Shugri,

Libe,

Gebru

2024

Preprint

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Background: Neonatal hyperbilirubinemia, also known as neonatal jaundice, is a condition characterized by yellowish discoloration of the skin and eyes caused by bilirubin buildup in the body. Understanding its prevalence, associated factors, and outcomes is crucial for effective management. Objectives: This study aimed to assess the prevalence, associated factors, and treatment outcomes of neonatal hyperbilirubinemia at Hiwot Fana Specialized Hospital, Eastern Ethiopia. Methodology: A hospital-based cross-sectional study was conducted from December 1, 2020, to December 30, 2020, involving 328 neonates admitted to the Neonatal Intensive Care Unit. Data were collected using a checklist and analyzed using SPSS version 22. Result: Neonatal hyperbilirubinemia prevalence was 44.2%, with 1.4% progressing to bilirubin encephalopathy. Sepsis (44.8%) and prematurity (22%) were major contributing factors. Most neonates were treated with phototherapy alone (82.3%), and 93.8% showed improvement. Conclusion: The study underscores the importance of early detection and management of neonatal hyperbilirubinemia to prevent adverse outcomes. Recommendations include integrating jaundice prevention into antenatal care and ensuring timely bilirubin level checks in neonates.

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Neonatal Hyperbilirubinemia: Magnitude and Associated Etiologic Factors among Neonates Admitted at Tikur Anbessa Specialized Hospital, Ethiopia

Cited by 11 publications

References 0 publications

Prevalence of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

Prevalence of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

Glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice in Africa; systematic review and meta-analysis

Retrospective Analysis of Neonatal Hyperbilirubinemia at Hiwot Fana Specialized Hospital, Ethiopia: Prevalence, Associated Factors, and Treatment Outcomes

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