Neonatal Heart-Enriched miR-708 Promotes Proliferation and Stress Resistance of Cardiomyocytes in Rodents

Deng, Shengqiong; Zhao, Qian; Zhen, Lixiao; Zhang, Chuyi; Liu, Cuicui; Wang, Guangxue; Zhang, Lin; Bao, Luer; Lü, Ying; Meng, Lingyu; Lu, Jianrong; Yu, Ping; Xin, Lin; Zhang, Yuzhen; Chen, Yihan; Fan, Huimin; Cho, William C.; Liu, Zhongmin; Yu, Zuoren

doi:10.7150/thno.16478

Cited by 50 publications

(37 citation statements)

References 25 publications

(27 reference statements)

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“…Primary cardiomyocytes isolated from the heart tissues of neonatal rats were used in the present study. There are some differences in the capacity to proliferate and to induce transdifferentiation between neonatal cardiomyocytes and adult cardiomyocytes, adult cardiomyocytes are closer to the myocardial model in vivo in structure and function. So, further experimental confirmation in adult cardiomyocytes is required.…”

Section: Discussionmentioning

confidence: 99%

The RhoA/ROCK pathway mediates high glucose‐induced cardiomyocyte apoptosis via oxidative stress, JNK, and p38MAPK pathways

Zhou

Sun

Zhang

et al. 2018

Diabetes Metabolism Res

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Section: Discussionmentioning

confidence: 99%

The RhoA/ROCK pathway mediates high glucose‐induced cardiomyocyte apoptosis via oxidative stress, JNK, and p38MAPK pathways

Zhou

Sun

Zhang

et al. 2018

Diabetes Metabolism Res

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“…Recently, a variety of studies have validated that noncoding RNAs (ncRNAs) participated in the development of diverse CVDs by regulating cell differentiation, proliferation, apoptosis, necrosis and autophagy . ncRNAs, which have been extensively investigated in the past decades, are characterized by having no significant protein‐coding potential.…”

Section: Introductionmentioning

confidence: 99%

The novel regulatory role of lncRNA‐miRNA‐mRNA axis in cardiovascular diseases

Huang

2018

J Cellular Molecular Medi

372

291

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Long noncoding RNAs (lncRNAs) are RNAs longer than 200 nt in length that are characterized by low levels of sequence conservation and expression; lncRNAs modulate various biological functions at epigenetic, transcriptional and post‐transcriptional levels, or directly regulate protein activity. As a family of small and evolutionarily conserved noncoding RNAs, microRNAs (miRNAs) are capable of regulating physiological and pathological processes via inhibiting target mRNA translation or promoting mRNA degradation. A number of studies have confirmed that both lncRNAs and miRNAs are closely associated with the development of cardiovascular diseases (CVDs), such as cardiac remodelling, heart failure, myocardial injury and arrhythmia, and that they act as biomarkers, potential therapeutic targets or strong indicators of prognosis; however, the underlying molecular mechanism has not been elucidated. Recently, emerging evidence showed that the novel regulatory mechanism underlying the crosstalk among lncRNAs, miRNAs and mRNAs plays a pivotal role in the pathophysiological processes of CVDs in response to stress stimuli. In this review, I comprehensively summarized the regulatory relationship of lncRNAs, miRNAs and mRNAs and highlighted the important role of the lncRNA‐miRNA‐mRNA axis in CVDs.

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“…39 Some findings strengthen the potential of applying miRNAs, such as miR-708, to reconstitute lost cardiomyocytes in injured hearts and may provide a novel candidate for promoting heart regeneration. 40 Therefore, with further improving the miRNA detection technology, miRNA may become a marker for early diagnosis and treatment of AMI.…”

Section: Discussionmentioning

confidence: 99%

Expression profiling and bioinformatics analysis of circulating microRNAs in patients with acute myocardial infarction

Zhong

et al. 2019

Clinical Laboratory Analysis

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Objective Acute Myocardial Infarction (AMI) is the most severe type of coronary atherosclerotic heart diseases. MiRNA is a class of endogenous noncoding small molecule RNA, which plays an important regulatory role in the development of some diseases. Methods We examined the miRNA expression profiles in 16 patients with AMI compared with 6 non‐AMI controls using RNA sequencing. Results Compared with the miRNA expression profiles of non‐AMI controls, a total of 181 differentially expressed miRNAs were discriminated in AMI patients, of which 96 upregulated miRNAs and 85 downregulated miRNAs. The top ten upregulated miRNAs were as follows: miR‐449a‐5p, miR‐126‐5p, miR‐93‐5p, miR‐199a‐3p, miR‐4454, miR‐6880‐3p, miR‐3135a, miR‐548ad‐5p, miR‐4508, and miR‐556‐5p; while the top ten downregulated were as follows: miR‐6805‐5p, miR‐1228‐5p, miR‐939‐5p, miR‐615‐3p, miR‐6780a‐5p, miR‐6857‐3p, miR‐5088‐55p, miR‐7155‐3p, miR‐184, and miR‐4525. And the qRT‐PCR results of differentially expressed miRNAs showed the same result as high‐throughput sequencing data. For these 181 differentially expressed miRNAs, 19 841 target genes were predicted by GO analysis. The enrichment analysis revealed 2061 involved in biological processes, 353 in molecular function and 303 in cellular components. To identify biological pathways in AMI as compared to non‐AMI, the target genes of differentially expressed miRNAs were mapped to the classical signal transduction pathway in KEGG, indicating that 214 classes were enriched. ROC analysis showed that the circulating miRNAs had the important value for AMI diagnosis and supported the previous conclusions that circulating miRNAs were effective to diagnose the AMI as a novel biomarker. Conclusions Our findings require further research to confirm. It may provide a meaningful reference for the diagnosis and treatment of AMI.

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Neonatal Heart-Enriched miR-708 Promotes Proliferation and Stress Resistance of Cardiomyocytes in Rodents

Cited by 50 publications

References 25 publications

The RhoA/ROCK pathway mediates high glucose‐induced cardiomyocyte apoptosis via oxidative stress, JNK, and p38MAPK pathways

The RhoA/ROCK pathway mediates high glucose‐induced cardiomyocyte apoptosis via oxidative stress, JNK, and p38MAPK pathways

The novel regulatory role of lncRNA‐miRNA‐mRNA axis in cardiovascular diseases

Expression profiling and bioinformatics analysis of circulating microRNAs in patients with acute myocardial infarction

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