2018
DOI: 10.1111/acer.13598
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Neonatal Ethanol Exposure Causes Behavioral Deficits in Young Mice

Abstract: Based on these data, this neonatal intubation mouse model may be useful for future mechanistic and genetic studies of FASD and for screening of novel therapeutic agents.

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Cited by 16 publications
(5 citation statements)
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“…The current results agree with clinical [ 44 , 45 ] and animal findings [ 46 , 47 ] that showed deficits in spatial memory in adults associated with neonatal ethanol exposure. However, few studies have emphasized sex differences in memory performance in adult animals exposed to ethanol during perinatal period [ 48 , 49 , 50 , 51 ].…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…The current results agree with clinical [ 44 , 45 ] and animal findings [ 46 , 47 ] that showed deficits in spatial memory in adults associated with neonatal ethanol exposure. However, few studies have emphasized sex differences in memory performance in adult animals exposed to ethanol during perinatal period [ 48 , 49 , 50 , 51 ].…”
Section: Discussionsupporting
confidence: 92%
“…One study, for example, demonstrated that even a single exposure to ethanol in the early postnatal period induced memory impairments in adult male, but not female animals [ 52 ]. Other studies reported that three days of ethanol exposure (PND7–9) induced deficits only in adult male animals [ 48 , 49 ], but longer ethanol exposure (over 5–6 days) promoted memory impairments in both male and female rats [ 47 , 50 , 53 ]. We saw deleterious effect of ethanol on memory in both sexes.…”
Section: Discussionmentioning
confidence: 99%
“…The Morris water maze (MWM) is one of most common behavioral tests of spatial learning for rodents ( Vorhees and Williams, 2006 ). The MWM was performed based on a previously published method with some modifications ( Xu et al, 2018 ). Briefly, each mouse was placed in a round plastic tub with a diameter of 108 cm filled with white-painted water at the temperature of 22–23°C to locate and escape onto a submerged platform.…”
Section: Methodsmentioning
confidence: 99%
“…The Morris water maze (MWM) is a test of spatial learning and memory for rodents [ 41 , 42 ]. Animals undergo training and testing sessions include spatial learning, probe trials, reversal learning, and visible cue.…”
Section: Methodsmentioning
confidence: 99%