2020
DOI: 10.3390/brainsci10080565
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Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice

Abstract: Thiamine deficiency (TD) has detrimental effects on brain health and neurobehavioral development, and it is associated with many aging-related neurological disorders. To facilitate TD-related neuropsychological studies, we generated a TD mouse model by feeding a thiamine-deficient diet for 30 days, followed by re-feeding the control diet for either one week or 16 weeks as recovery treatment. We then performed neurobehavioral tests in these two cohorts: cohort of one week post TD treatment (1 wk-PTDT) and 16 we… Show more

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Cited by 3 publications
(3 citation statements)
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“…Thiamine deficiency (TD) has long been associated with alcoholism ( Leevy and Baker, 1968 ; Woodhill and Nobile, 1972 ; Butterworth, 1995 ) and has been implicated as a key factor for alcohol-induced brain damages ( Martin et al, 2003 ; Liu et al, 2017 ). Our recent publication indicated thiamine deficiency can cause anxiety-like behaviors ( Li et al, 2020 ). Xu et al showed chronic voluntary alcohol drinking caused a significant decrease in the levels of thiamine in the brain but not the blood of male cHAP mice ( Xu et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…Thiamine deficiency (TD) has long been associated with alcoholism ( Leevy and Baker, 1968 ; Woodhill and Nobile, 1972 ; Butterworth, 1995 ) and has been implicated as a key factor for alcohol-induced brain damages ( Martin et al, 2003 ; Liu et al, 2017 ). Our recent publication indicated thiamine deficiency can cause anxiety-like behaviors ( Li et al, 2020 ). Xu et al showed chronic voluntary alcohol drinking caused a significant decrease in the levels of thiamine in the brain but not the blood of male cHAP mice ( Xu et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…Of note, thiamine is a water-soluble vitamin that plays an important role in the biological processes such as glucose metabolism ( Polegato et al, 2019 ). There is evidence showing that the deficiency of the thiamine led to long-term neurobehavioral deficits, such as anxiety disorders ( Li et al, 2020 ). In fact, thiamine supplementation can prevent the occurrence of anxietious behaviors ( Markova et al, 2017 ).…”
Section: Discussionmentioning
confidence: 99%
“…Before the test, rats were placed on a rotarod device (ZS-RDM-XS, China) and allowed to explore the rotarod three times (10 min/time) with a constant speed of 4 r/min, and rest for 30 min at an interval. The rod was rotated from a speed of 10 to 20 rpm for 10 min ( Li et al, 2020 ). The latency to fall, which is the cumulative time (s) that each animal remained on the rotating rod, was recorded as an indicator of its motor coordination ( Shi et al, 2021 ).…”
Section: Methodsmentioning
confidence: 99%