Neonatal administration of goat whey modulates memory and cortical spreading depression in rats previously suckled under different litter sizes: Possible role of sialic acid

Medeiros, Larissa de Brito; Vitor-de-Lima, Suênia Marcele; Benevides, Regina de Deus Lira; Queiroga, Rita de Cássia Ramos do Egypto; Guedes, Rubem Carlos Araújo

doi:10.1080/1028415x.2016.1227762

Cited by 9 publications

(1 citation statement)

References 56 publications

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“…Xu et al (2015) reported that goat milk based formula resulted in superior cognitive and spatial ability in weaned Sprague Dawley rats, as compared to control rats and also as compared to rats supplemented with cow milk based formula 9 . Medeiros et al (2018) made use of goat whey, which is a by-product of cheese curd production from goat milk, to test memory performance in moderately malnourished male pups; they reported that goat whey was able to enhance memory performance in those pups when compared with the pups in the control group 21 . Besides these findings, a few studies have reported the beneficial effects of the individual contents of goat milk on memory and learning.…”

Section: Discussionmentioning

confidence: 99%

Memory-enhancing effects of goat milk in D-galactose-induced aging rat model

et al. 2020

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Introduction: Aging is a physiological process accompanied by cognitive decline, particularly in memory deterioration. D-galactose is a reducing monosaccharide which, if systemically exposed, causes accelerated senescence in several organs and is widely being used as an ideal agent to induce brain aging in animal models. Goat milk is a food of high nutritional value which has been demonstrated to possess strong antioxidant and anti-inflammatory properties. However, thus far, little is known of its possible effects on the brain, especially on memory during aging. The present study examined the efficiency of goat milk supplementation on memory performance in a D-galactose induced aging rat model. Methods: Fifty-two male Sprague Dawley rats were randomly divided into four groups: 1) control group, 2) goat milk treated group, 3) D-galactose treated group, and 4) goat milk plus D-galactose treated group. D-galactose (120 mg/kg subcutaneously) and/or goat milk (1 g/kg orally) were administered continuously for six weeks, preceded and followed by novel object recognition and T-maze tests. Results: Prior to goat milk and D-galactose administration, there was no significant difference (p>0.05) in memory performance among all groups. Six weeks of D-galactose administration significantly decreased (p<0.001) short-term, long-term and spatial memory performance. Goat milk supplementation in the D-galactose induced rats managed to protect against memory decline, as exhibited by significantly higher (p<0.0001) short-term, long-term and spatial memory performance of the D-galactose plus goat milk treated group, compared to the D-galactose treated group. Conclusion: In conclusion, goat milk possesses memoryenhancing effects and, hence. may be useful in protecting against age-related memory deficits.

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Section: Discussionmentioning

confidence: 99%