Neoflavonoids as Prospective Compounds Against Parasitic Neglected Tropical Infections and Human Immunodeficiency Virus

Saldanha, Gláucio Barros; Oliveira, George Laylson da Silva; Silva, José C.C.L. da; Oliveira, Maria Cristina Pimenta de; Silva, Ana P.S.C.L. da; David, Juceni P. de Lima

doi:10.2174/1573407213666170104152315

Cited by 5 publications

(1 citation statement)

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“…Neoflavonoids contain neoflavone (4-arylcoumarin), 3,4-dihydro-4-arylcoumarins, and neoflavene (4-arylchromene) [7]. Neoflavonoids are present in a wide variety of plants from families Passifloraceae, Asteraceae, Clusiaceae, Leguminosae, Rubiaceae, and Rutaceae [51]. Calophyllolide isolated in 1951 from extracts of Calophyllum inophyllum seeds was the first new neoflavonoid from natural sources [52].…”

Section: Neoflavonoidsmentioning

confidence: 99%

Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review

Lou

Hu²,

et al. 2021

Molecules

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Flavonoids belong to a class of plant secondary metabolites that have a polyphenol structure. Flavonoids show extensive biological activity, such as antioxidative, anti-inflammatory, anti-mutagenic, anti-cancer, and antibacterial properties, so they are widely used in the food, pharmaceutical, and nutraceutical industries. However, traditional sources of flavonoids are no longer sufficient to meet current demands. In recent years, with the clarification of the biosynthetic pathway of flavonoids and the development of synthetic biology, it has become possible to use synthetic metabolic engineering methods with microorganisms as hosts to produce flavonoids. This article mainly reviews the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of flavonoids. Meanwhile, the application of co-culture systems in the biosynthesis of flavonoids is emphasized in this review.

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Section: Neoflavonoidsmentioning

confidence: 99%