Absence of toxicity in Swiss mice following treatment with 7-acetoxy-4-aryl-3,4-dihydrocoumarin: Acute and repeated-dose toxicity study

Saldanha, Gláucio Barros; Saldanha, Glaucia Barros; Sousa, Marina Rebeca Soares Carneiro de; Oliveira, George Laylson da Silva; Silva, Ana Paula dos Santos C.L. da; David, Jorge M.; David, Juceni P.

doi:10.1016/j.yrtph.2018.01.003

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2021

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“…Clinical signs of toxicity (e.g. general appearance, ataxia, vocal fremitus, irritability, body tone, tremor, salivation, tearing, palpable ptosis, seizures and abnormal movements) were monitored continuously for 1 h after the administration, periodically during the first 24 h and then, daily for a total of 14 days ( Da Silva et al., 2016 ; Saldanha et al., 2018 ).…”

Section: Methodsmentioning

confidence: 99%